Zusammenfassung
Inzidentalome der Nebennieren sind Raumforderungen, die im Rahmen schnittbildgebender Diagnostik, welche nicht zur Abklärung von Nebennierenerkrankungen oder zum Staging bei Tumorerkrankungen erfolgt, auffallen. Es sind relativ häufige Befunde, welche einer strukturierten Abklärung bedürfen. In vielen Fällen ist eine Beobachtung gerechtfertigt. Bei der diagnostischen Aufarbeitung muss geklärt werden, ob es sich um einen funktionellen Nebennierentumor handelt und/oder ob es Hinweise für ein malignes Leiden gibt. Handelt es sich um einen nichtfunktionellen Tumor, der eine Größe von 4 cm nicht übersteigt, ist ein abwartendes Verhalten gerechtfertigt. Funktionelle Tumoren und jede Raumforderung größer als 6 cm müssen zur Behandlung des Hormonexzesses, bzw. zum Ausschluss eines malignen Tumors reseziert werden. Eine diagnostische Punktion des Tumors ist nur in Ausnahmefällen und dann nur nach Ausschluss eines Phäochromozytoms indiziert.
Abstract
Adrenal incidentalomas are clinically inapparent masses detected incidentally with imaging studies conducted for other reasons. They are relatively common and require structured diagnostic workup. In many cases surveillance is warranted. The diagnostic workflow has to reveal whether the mass is hormonally functioning and/or if there is evidence of malignancy. If the tumor is functionally silent and not larger than 4 cm, surveillance is warranted. Functioning tumors and masses larger than 6 cm have to be resected. Fine-needle aspiration biopsy is indicated in very rare cases, but pheochromocytoma has to be ruled out first.
Literatur
Allolio B, Fassnacht M (2006) Adrenocortical carcinoma: clinical update. J Clin Endocrinol Metab 91: 2027–2037
Amar L, Bertherat J, Baudin E et al. (2005) Genetic testing in pheochromocytoma or functional paraganglioma J Clin Oncol 23: 8812–8818
Angeli A, Osella G, Ali A, Terzolo M (1997) Adrenal incidentaloma: an overview of clinical and epidemiological data from the National Italian Study Group. Horm Res 47: 279–283
Beuschlein F, Nies C, Reincke M (2007) Das Inzidentalom und seltene Tumoren in Praxis der Visceralchirurgie. In: Rothmund M, Siewert JR, Schumpelick V (eds) Endokrine Chirurgie. Springer, Heidelberg
Bonjer HJ, Sorm V, Berends FJ et al. (2000) Endoscopic retroperitoneal adrenalectomy: lessons learned from 111 consecutive cases. Ann Surg 232: 796–803
Chiodini I, Tauchmanova L, Torlontano M et al. (2002) Bone involvement in eugonadal male patients with adrenal incidentaloma and subclinical hypercortisolism. J Clin Endocrinol Metab 87: 5491–5494
Copeland PM (1999) The incidentally discovered adrenal mass: an update. Endocrinologist 9: 415–423
Emral R, Uysal AR, Asik M et al. (2003) Prevalence of subclinical Cushing’s syndrome in 70 patients with adrenal incidentaloma: clinical, biochemical and surgical outcomes. Endocr J 50: 399–408
Erbil Y, Ademoglu E, Ozbey N et al. (2006) Evaluation of the cardiovascular risk in patients with subclinical Cushing syndrome before and after surgery. World J Surg 30: 1665–1671
Fardella CE, Mosso L, Gomez-Sanchez C et al. (2000) Primary hyperaldosteronism in essential hypertensives: prevalence, biochemical profile, and molecular biology. J Clin Endocrinol Metab 85: 1863–1867
Fernandez-Cruz L, Taura P, Saenz A et al. (1996) Laparoscopic approach to pheochromocytoma: hemodynamic changes and catecholamine secretion. World J Surg 20: 762–768
Gagner M, Lacroix A, Bolte E (1992) Laparoscopic adrenalectomy in Cushing‘s syndrome and pheochromocytoma. N Engl J Med 327: 1033
Goldstein RE, O‘Neill JA Jr, Holcomb GW 3rd et al. (1999) Clinical experience over 48 years with pheochromocytoma. Ann Surg 229: 755–756
Gorges R, Knappe G, Gerl H et al. (1999) Diagnosis of Cushing’s syndrome: re-evaluation of midnight plasma cortisol vs urinary free cortisol and low-dose dexamethasone suppression test in a large patient group. J Endocrinol Invest 22: 241–249
Grumbach MM, Biller BM, Braunstein GD et al. (2003) Management of the clinically inapparent adrenal mass („incidentaloma“). Ann Intern Med 138: 424–429
Heinz-Peer G, Honigschnabel S, Schneider B et al. (1999) Characterization of adrenal masses using MR imaging with histopathologic correlation. Am J Roentgenol 173: 15–22
Henry JF, Sebag F, Iacobone M, Mirallie E (2002) Results of laparoscopic adrenalectomy for large and potentially malignant tumors. World J Surg 26: 1043–1047
Hofle G, Gasser RW, Lhotta K et al. (1998) Adrenocortical carcinoma evolving after diagnosis of preclinical Cushing‘s syndrome in an adrenal incidetnaloma. A case report. Horm Res 50: 237–242
Kann PH, Wirkus B, Behr T et al. (2004) Endosonographic imaging of benign and malignant pheochromocytomas. J Clin Endocrinol Metab 89: 1694–1697
Kloos RT, Gross MD, Francis IR et al. (1995) Incidentally discovered adrenal masses. Endocr Rev 16: 460–484
Klose KJ (2007) Bildgebende Verfahren in Praxis der Visceralchirurgie. In: Rothmund M, Siewert JR, Schumpelick V (eds) Endokrine Chirurgie. Springer, Heidelberg
Lee JE, Evans DB, Hickey RC et al. (1998) Unknown primary cancer presenting as an adrenal mass: frequency and implications for diagnostic evaluation of adrenal incidentalomas. Surgery 124: 1115–1122
Mantero F, Amsini AM, Opocher G et al. (1997) Adrenal incidentaloma: an overview of hormonal data from the National Italian Study group. Horm Res 47: 284–289
Motta-Ramirez GA, Remer EM, Herts BR et al. (2005) Comparison of CT findings in symptomatic and incidentally discovered pheochromocytomas. AJR Am J Roentgenol 185: 684–688
Musante F, Derchi LE, Bazzocchi M (1991) MR imaging of adrenal myelolipomas. J Comput Assist Tomogr 15: 111–114
Neumann HB, Bausch B, McWhinney SR et al. (2002) Germline mutations in non-syndromic pheochromocytoma. N Engl J Med 346: 1459–1466
Noble MJ, Montaggue DK, Levin HS (1982) Myelolipoma: An unusual surgical lesion of the adrenal gland. Cancer 49: 952
Perry CG, Sawka AM, Singh R et al. (in press) The diagnostic efficacy of urinary fractionated metanephrines measured by tandem mass spectrometry in detection of pheochromocytoma. Clin Endocrinol (Oxf): Epub ahead of print
Prinz RA (1995) A comparison of laparoscopic and open adrenalectomies. Arch Surg 130: 489
Rossi R, Tauchmanova L, Luciano A et al. (2000) Subclinical Cushing’s syndrome in patients with adrenal incidentaloma: clinical and biochemical features. J Clin Endocrinol Metab 85: 1440–1448
Saunders BD, Doherty GM (2004) Laparoscopic adrenalectomy for malignant disease. Lancet Oncol 5: 718–726
Sawka AM, Jaeschke R, Singh RJ, Young WF Jr (2003) A comparison of biochemical tests for pheochromocytoma: measurement of fractionated plasma metanephrines compared with the combination of 24-hour urinary metanephrines and catecholamines. J Clin Endocrinol Metab 88: 553–558
Sawka AM, Prebtani AP, Thabane L et al. (2004) A systematic review of the literature examining the diagnostic efficacy of measurement of fractionated plasma free metanephrines in the biochemical diagnosis of pheochromocytoma. BMC Endocr Disord 4: 2
Seccia TM, Fassina A, Nussdorfer GG et al.(2005) Aldosterone-producing adrenocortical carcinoma: an unusual cause of Conn’s syndrome with an ominous clinical course Endocr Relat Cancer 12: 149–59
Shen WT, Lim RC, Siperstein AE et al. (1999) Laparoscopic vs open adrenalectomy for the treatment of primary hyperaldosteronism. Arch Surg 134: 628
Seiler L, Reincke M (2003) The aldosterone to Renin ratio in secondary hypertension. Herz 28: 686–691
Sturgeon C, Kebebew E (2004) Laparoscopic adrenalectomy for malignancy. Surg Clin North Am 84: 755–774
Sturgeon C, Shen WT, Clark OH et al. (2006) Risk assessment in 457 adrenal cortical carcinomas: how much does tumor size predict the likelihood of malignancy? J Am Coll Surg 202: 423–430
Sutton MG, Sheps SG, Lie JT (1981) Prevalence of clinically unsuspected pheochromocytoma: review of a 50-year autopsy series. Mayo Clin Proc 56: 354–360
Suzuki K, Ushiyama T, Mugiya S et al. (1997) Hazards of laparoscopic adrenalectomy in patients with adrenal malignancy. J Urol 158: 2227
Terzolo M, Pia A, Ali A et al. (2002) Adrenal incidentaloma: a new cause of the metabolic syndrome? J Clin Endocrinol Metab 87: 998–1003
Tsagarakis S, Vassiliadi D, Thalassinos N (2006) Endogenous subclinical hypercortisolism: diagnostic uncertainties and clinical implications. J Endocrinol Invest 29: 471–482
Tsagarakis S, Roboti C, Kokkoris P et al. (1998) Elevated post-dexamethasone suppression cortisol concentrations correlate with hormonal alterations of the hypothalamo-pituitary adrenal axis in patients with adrenal incidentalomas. Clin Endocrinol (Oxf) 49: 165–71
Slooten H van, Schaberg A, Smeenk D, Moolenaar AJ (1985) Morphologic characteristics of benign and malignant adrenocortical tumors Cancer 55: 766–773
Vassilopoulou-Sellin R, Schultz PN (2001) Adrenocortical carcinoma. Clinical outcome at the end of the 20th century. Cancer 92: 1113–1121
Young WF Jr (2000) Management approaches to adrenal incidentalomas: a view from Rochester, Minnesota. Endocrinol Metab Clin North Am 29: 159–185
Young WF, Stanson AW, Thompson GB et al. (2004) Role for adrenal venous sampling in primary aldosteronism. Surgery 136: 1227–1235
Young WF Jr (2007) The incidentally discovered adrenal mass. N Engl J Med 356: 601–610
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Langer, P., Waldmann, J. & Rothmund, M. Inzidentalome der Nebenniere. Chirurg 78, 721–728 (2007). https://doi.org/10.1007/s00104-007-1365-x
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DOI: https://doi.org/10.1007/s00104-007-1365-x