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Effektormoleküle des angeborenen Immunsystems zur Abwehr von Wundinfektionen

Effector molecules of the innate immune system for treatment of wound infections

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Zusammenfassung

Die Haut ist ein wesentliches Immunorgan des menschlichen Körpers und repräsentiert die wichtigste Barriere zwischen Körper und Umwelt. Als vorderste Verteidigungslinie der Haut gilt das angeborene Immunsystem („innate immune system“), das im Gegensatz zum adaptiven Immunsystem sofort gegen eindringende pathogene Mikroben reagiert. Antimikrobielle Peptide stellen die Basis des phylogenetisch älteren Teils des Immunsystems dar. Neue Studien haben gezeigt, dass eine reduzierte lokale Expression antimikrobieller Peptide ursächlich an der supprimierten Immunantwort und den damit verbundenen höheren Infektionsraten bei Schwerbrandverletzten beteiligt ist. Das Oberflächenepithel besitzt eine wesentliche Funktion bei der Erkennung einer Kolonialisierung durch Mikroorganismen und bei der initialen antimikrobiellen Abwehr.

Abstract

Skin is a substantial immune organ and represents the most important barrier against the potentially hostile environment. Its first line of defense are effector molecules of the innate immune system, which in contrast to the adaptive immune system reacts immediately against penetrating pathogenic microbes. Antimicrobial peptides represent the basis of the phylogenetically oldest part of the immune system. New studies show that reduced local cutaneous expression of antimicrobial peptide in burned skin is involved in the higher incidence of wound infections. The epithelium has an essential function in recognizing colonies of micro-organisms and in initial antimicrobial defenses.

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Authors and Affiliations

  1. Klinik für Plastische Chirurgie und Schwerbrandverletzte, BG Kliniken Bergmannsheil, Ruhr-Universität, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Deutschland

    L. Steinsträßer, S. Langer, M. Lehnhardt & H.U. Steinau

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  1. L. Steinsträßer
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  2. S. Langer
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  3. M. Lehnhardt
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  4. H.U. Steinau
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Correspondence to L. Steinsträßer.

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Steinsträßer, L., Langer, S., Lehnhardt, M. et al. Effektormoleküle des angeborenen Immunsystems zur Abwehr von Wundinfektionen. Chirurg 78, 343–348 (2007). https://doi.org/10.1007/s00104-007-1314-8

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  • DOI: https://doi.org/10.1007/s00104-007-1314-8

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