Empfehlungen zur Prävention und Kontrolle von Methicillin-resistenten Staphylococcus aureus-Stämmen (MRSA) in medizinischen und pflegerischen Einrichtungen

Empfehlung der Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO) beim Robert Koch-Institut

An Erratum to this article was published on 05 May 2015

Literatur

  1. 1.

    Chen LF (2013) The changing epidemiology of methicillin-resistant Staphylococcus aureus: 50 years of a superbug. Am J Infect Control 41:448–451

    PubMed  Google Scholar 

  2. 2.

    Klevens RM, Morrison MA, Nadle J et al (2007) Invasive methicillin-resistant Staphylococcus aureus infections in the United States. JAMA 298:1763–1771

    CAS  PubMed  Google Scholar 

  3. 3.

    GERMAP 2010 Antibiotika-Resistenz und -Verbrauch (2010) Bericht über den Antibiotikaverbrauch und die Verbreitung von Antibiotikaresistenzen in der Human- und Veterinärmedizin in Deutschland. Bundesamt für Verbraucherschutz und Lebensmittelsicherheit. Paul-Ehrlich-Gesellschaft für Chemotherapie e.V., Infektiologie Freiburg. Antiinfectives Intelligence Gesellschaft für klinisch-mikrobiologische Forschung und Kommunikation mbH

  4. 4.

    The European Centre for Disease Prevention and Control (ECDC), Antimicrobial resistance interactive database (EARS-Net) (2012). http://www.ecdc.europa.eu/en/healthtopics/antimicrobial_resistance/database/Pages/database.aspx. Zugegriffen: April 2014

  5. 5.

    Kommission für Krankenhaushygiene und Infektionsprävention (2005) Infektionsprävention in Heimen. Bundesgesundheitsblatt 48:1061–1080

    Google Scholar 

  6. 6.

    Muto CA, Jernigan JA, Ostrowsky BE et al (2003) SHEA guideline for preventing nosocomial transmission of multidrug-resistant strains of Staphylococcus aureus and enterococcus. Infect Control Hosp Epidemiol 24:362–386

    PubMed  Google Scholar 

  7. 7.

    Korczak D, Schöffmann C (2010) Medizinische Wirksamkeit und Kosten-Effektivität von Präventions- und Kontrollmaßnahmen gegen Methicillin-resistente Staphylococcus aureus (MRSA)-Infektionen im Krankenhaus. GMS Health Technol Assess 6:Doc04

  8. 8.

    Cooper BS, Stone SP, Kibbler CC et al (2003) Systematic review of isolation policies in the hospital management of methicillin-resistant Staphylococcus aureus: a review of the literature with epidemiological and economic modelling. Health Technol Assess 7:1–194

    CAS  PubMed  Google Scholar 

  9. 9.

    Siegel JD, Rhinehart E, Jackson M et al (2007) 2007 Guideline for isolation precautions: preventing transmission of infectious agents in health care settings. Am J Infect Control 35:S65–S164

  10. 10.

    Siegel JD, Rhinehart E, Jackson M et al (2007) Management of multidrug-resistant organisms in health care settings, 2006. Am J Infect Control 35:S165–S193

  11. 11.

    Strausbaugh LJ, Siegel JD, Weinstein RA (2006) Preventing transmission of multidrug-resistant bacteria in health care settings: a tale of 2 guidelines. Clin Infect Dis 42:828–835

    PubMed  Google Scholar 

  12. 12.

    Kommission für Krankenhaushygiene und Infektionsprävention (1999) Empfehlung zur Prävention und Kontrolle von Methicillin-resistenten Staphylococcus aureus-Stämmen (MRSA) in Krankenhäusern und anderen medizinischen Einrichtungen. Bundesgesundheitsblatt 42:954–958

    Google Scholar 

  13. 13.

    Kommission für Krankenhaushygiene und Infektionsprävention (2008) Kommentar zu den „Empfehlungen zur Prävention und Kontrolle von MRSA-Stämmen in Krankenhäusern und anderen medizinischen Einrichtungen“. Epidemiol Bull 42:363–364

  14. 14.

    Kommission für Krankenhaushygiene und Infektionsprävention (2002) Ausbruchmanagement und struktuiertes Vorgehen bei gehäuftem Auftreten nosokomialer Infektionen. Bundesgesundheitsblatt 45:180–186

    Google Scholar 

  15. 15.

    Kommission für Krankenhaushygiene und Infektionsprävention (2000) Empfehlungen zur Händehygiene. Bundesgesundheitsblatt 43:230–233

    Google Scholar 

  16. 16.

    Kommission für Krankenhaushygiene und Infektionsprävention (2004) Anforderungen an die Hygiene bei der Reinigung und Desinfektion von Flächen. Bundesgesundheitsblatt 47:51–61

    Google Scholar 

  17. 17.

    Kommission für Krankenhaushygiene und Infektionsprävention (2010) Anforderungen an die Hygiene bei der medizinischen Versorgung von immunsupprimierten Patienten. Bundesgesundheitsblatt 53:357–388

    Google Scholar 

  18. 18.

    Kommission für Krankenhaushygiene und Infektionsprävention (2013) Risikocharakterisierung intensivmedizinisch behandelter Früh- und Neugeborener und Daten zur Ist-Situation in deutschen neonatologischen Intensivpflegestationen 2013. Fachliche Erläuterungen zu folgender Empfehlung: Praktische Umsetzung sowie krankenhaushygienische und infektionspräventive Konsequenzen des mikrobiellen Kolonisationsscreenings bei intensivmedizinisch behandelten Früh- und Neugeborenen. Ergänzende Empfehlung der Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO). Supplement zum Epidemiologischen Bulletin Nr. 42. Robert Koch-Institut, Berlin

  19. 19.

    Kommission für Krankenhaushygiene und Infektionsprävention (2012) Ergänzende Empfehlung zur „Prävention nosokomialer Infektionen bei neonatologischen Intensivpflegepatienten mit einem Geburtsgewicht unter 1.500 g“ (2007). Epidemiol Bull 2:13–15

    Google Scholar 

  20. 20.

    Kommission für Krankenhaushygiene und Infektionsprävention (2007) Empfehlung zur Prävention nosokomialer Infektionen bei neonatologischen Intensivpflegepatienten mit einem Geburtsgewicht unter 1.500 g. Bundesgesundheitsblatt 50:1265–1303

    Google Scholar 

  21. 21.

    Robert Koch-Institut (2013) Surveillance nosokomialer Infektionen sowie die Erfassung von Krankheitserregern mit speziellen Resistenzen und Multiresistenzen – Fortschreibung der Liste der gemäß § 4 Abs. 2 Nr. 2 Buchstabe b in Verbindung mit § 23 Abs. 4 IfSG zu erfassenden nosokomialen Infektionen und Krankheitserreger mit speziellen Resistenzen und Multiresistenzen. Bundesgesundheitsblatt 56:580–583

  22. 22.

    Kommission für Krankenhaushygiene und Infektionsprävention (2010) Die Kategorien der Richtlinie für Krankenhaushygiene und Infektionsprävention – Aktualisierung der Definitionen. Bundesgesundheitsblatt 53:754–756

    Google Scholar 

  23. 23.

    van Belkum A, Verkaik NJ, de Vogel CP et al (2009) Reclassification of Staphylococcus aureus nasal carriage types. J Infect Dis 199:1820–1826

    PubMed  Google Scholar 

  24. 24.

    Becker K (2008) Virulenzfaktoren und molekulare Epidemiologie von Staphylococcus aureus – Renaissance eines alten Erregers? Kinder Jugendmed 8:73–82

  25. 25.

    Speziale P, Pietrocola G, Rindi S et al (2009) Structural and functional role of Staphylococcus aureus surface components recognizing adhesive matrix molecules of the host. Future Microbiol 4:1337–1352

    CAS  PubMed  Google Scholar 

  26. 26.

    Dinges MM, Orwin PM, Schlievert PM (2000) Exotoxins of Staphylococcus aureus. Clin Microbiol Rev 13:16–34

    CAS  PubMed  PubMed Central  Google Scholar 

  27. 27.

    Becker K, Friedrich AW, Lubritz G et al (2003) Prevalence of genes encoding pyrogenic toxin superantigens and exfoliative toxins among strains of Staphylococcus aureus isolated from blood and nasal specimens. J Clin Microbiol 41:1434–1439

    CAS  PubMed  PubMed Central  Google Scholar 

  28. 28.

    Löffler B, Hussain M, Grundmeier M et al (2010) Staphylococcus aureus panton-valentine leukocidin is a very potent cytotoxic factor for human neutrophils. PLoS Pathog 6:e1000715

    PubMed  PubMed Central  Google Scholar 

  29. 29.

    Tristan A, Ferry T, Durand G et al (2007) Virulence determinants in community and hospital methicillin-resistant Staphylococcus aureus. J Hosp Infect 65(Suppl 2):105–109

    PubMed  Google Scholar 

  30. 30.

    von Eiff CF, Peters G et al (2004) Prevalence of genes encoding for members of the staphylococcal leukotoxin family among clinical isolates of Staphylococcus aureus. Diagn Microbiol Infect Dis 49:157–162

    Google Scholar 

  31. 31.

    Jappe U, Heuck D, Strommenger B et al (2008) Staphylococcus aureus in dermatology outpatients with special emphasis on community-associated methicillin-resistant strains. J Invest Dermatol 128:2655–2664

    CAS  PubMed  Google Scholar 

  32. 32.

    Monecke S, Slickers P, Ellington MJ et al (2007) High diversity of Panton-Valentine leukocidin-positive, methicillin-susceptible isolates of Staphylococcus aureus and implications for the evolution of community-associated methicillin-resistant S. aureus. Clin Microbiol Infect 13:1157–1164

    CAS  PubMed  Google Scholar 

  33. 33.

    Schaumburg F, Köck R, Mellmann A et al (2012) Population dynamics among methicillin-resistant Staphylococcus aureus isolates in Germany during a 6-year period. J Clin Microbiol 50:3186–3192

    PubMed  PubMed Central  Google Scholar 

  34. 34.

    Layer F, Werner G (2013) Eigenschaften, Häufigkeit und Verbreitung von MRSA in Deutschland – Update 2011/2012. Epidemiol Bull 21:187–193

    Google Scholar 

  35. 35.

    Hanberger H, Walther S, Leone M et al (2011) Increased mortality associated with methicillin-resistant Staphylococcus aureus (MRSA) infection in the intensive care unit: results from the EPIC II study. Int J Antimicrob Agents 38:331–335

    CAS  PubMed  Google Scholar 

  36. 36.

    Cosgrove SE, Sakoulas G, Perencevich EN et al (2003) Comparison of mortality associated with methicillin-resistant and methicillin-susceptible Staphylococcus aureus bacteremia: a meta-analysis. Clin Infect Dis 36:53–59

    PubMed  Google Scholar 

  37. 37.

    Whitby M, McLaws ML, Berry G (2001) Risk of death from methicillin-resistant Staphylococcus aureus bacteraemia: a meta-analysis. Med J Aust 175:264–267

    CAS  PubMed  Google Scholar 

  38. 38.

    Pujol M, Pena C, Pallares R et al (1996) Nosocomial Staphylococcus aureus bacteremia among nasal carriers of methicillin-resistant and methicillin-susceptible strains. Am J Med 100:509–516

    CAS  PubMed  Google Scholar 

  39. 39.

    Safdar N, Bradley EA (2008) The risk of infection after nasal colonization with Staphylococcus aureus. Am J Med 121:310–315

    PubMed  Google Scholar 

  40. 40.

    Coello R, Glynn JR, Gaspar C et al (1997) Risk factors for developing clinical infection with methicillin-resistant Staphylococcus aureus (MRSA) amongst hospital patients initially only colonized with MRSA. J Hosp Infect 37:39–46

    CAS  PubMed  Google Scholar 

  41. 41.

    Huang SS, Hinrichsen VL, Datta R et al (2011) Methicillin-resistant Staphylococcus aureus infection and hospitalization in high-risk patients in the year following detection. PloS One 6:e24340

    CAS  PubMed  PubMed Central  Google Scholar 

  42. 42.

    Datta R, Huang SS (2008) Risk of infection and death due to methicillin-resistant Staphylococcus aureus in long-term carriers. Clin Infect Dis 47:176–181

    PubMed  PubMed Central  Google Scholar 

  43. 43.

    Stenehjem E, Rimland D (2013) MRSA nasal colonization burden and risk of MRSA infection. Am J Infect Control 41:405–410

    PubMed  PubMed Central  Google Scholar 

  44. 44.

    Suetens C, Niclaes L, Jans B et al (2006) Methicillin-resistant Staphylococcus aureus colonization is associated with higher mortality in nursing home residents with impaired cognitive status. J Am Geriatr Soc 54:1854–1860

    PubMed  Google Scholar 

  45. 45.

    Wyllie DH, Crook DW, Peto TE (2006) Mortality after Staphylococcus aureus bacteraemia in two hospitals in Oxfordshire, 1997–2003: cohort study. BMJ 333:281

    PubMed  PubMed Central  Google Scholar 

  46. 46.

    Stamm AM, Long MN, Belcher B (1993) Higher overall nosocomial infection rate because of increased attack rate of methicillin-resistant Staphylococcus aureus. Am J Infect Control 21:70–74

    CAS  PubMed  Google Scholar 

  47. 47.

    Fukuta Y, Cunningham CA, Harris PL et al (2012) Identifying the risk factors for hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) infection among patients colonized with MRSA on admission. Infect Control Hosp Epidemiol 33:1219–1225

    PubMed  Google Scholar 

  48. 48.

    de Kraker ME, Wolkewitz M, Davey PG et al (2011) Clinical impact of antimicrobial resistance in European hospitals: excess mortality and length of hospital stay related to methicillin-resistant Staphylococcus aureus bloodstream infections. Antimicrob Agents Chemother 55:1598–1605

    PubMed  PubMed Central  Google Scholar 

  49. 49.

    Engemann JJ, Carmeli Y, Cosgrove SE et al (2003) Adverse clinical and economic outcomes attributable to methicillin resistance among patients with Staphylococcus aureus surgical site infection. Clin Infect Dis 36:592–598

    PubMed  Google Scholar 

  50. 50.

    Köck R, Becker K, Cookson B et al (2010) Methicillin-resistant Staphylococcus aureus (MRSA): burden of disease and control challenges in Europe. Euro Surveill 15:19688

    PubMed  Google Scholar 

  51. 51.

    Macedo-Vinas M, De Angelis G, Rohner P et al (2013) Burden of methicillin-resistant Staphylococcus aureus infections at a Swiss University hospital: excess length of stay and costs. J Hosp Infect 84:132–137

    CAS  PubMed  Google Scholar 

  52. 52.

    Ott E (2010) Costs of nosocomial pneumonia caused by methicillin-resistant Staphylococcus aureus. J Hosp Infect 76:300–303

    CAS  PubMed  Google Scholar 

  53. 53.

    Herr CEW (2003) Additional costs for preventing the spread of methicillin-resistant Staphylococcus aureus and a strategy for reducing these costs on a surgical ward. Infect Control Hosp Epidemiol 24:673–678

    PubMed  Google Scholar 

  54. 54.

    Harris SR, Feil EJ, Holden MT et al (2010) Evolution of MRSA during hospital transmission and intercontinental spread. Science 327:469–474

    CAS  PubMed  PubMed Central  Google Scholar 

  55. 55.

    Nübel U, Dordel J, Kurt K et al (2010) A timescale for evolution, population expansion, and spatial spread of an emerging clone of methicillin-resistant Staphylococcus aureus. PLoS Pathog 6:e1000855

    PubMed  PubMed Central  Google Scholar 

  56. 56.

    Köck R, Harlizius J, Bressan N et al (2009) Prevalence and molecular characteristics of methicillin-resistant Staphylococcus aureus (MRSA) among pigs on German farms and import of livestock-related MRSA into hospitals. Eur J Clin Microbiol Infect Dis 28:1375–1382

    PubMed  PubMed Central  Google Scholar 

  57. 57.

    Köck R, Brakensiek L, Mellmann A et al (2009) Cross-border comparison of the admission prevalence and clonal structure of methicillin-resistant Staphylococcus aureus. J Hosp Infect 71:320–326

    PubMed  Google Scholar 

  58. 58.

    Grabe C, Buckard R, El-Ansari T et al (2010) Flächendeckendes einmonatiges MRSA-Prävalenzscreening in Akut- und Rehakliniken in Siegen-Wittgenstein. Epidemiol Bull 18:163–166

    Google Scholar 

  59. 59.

    Reich-Schupke S, Geis G, Reising M et al (2010) MRSA in dermatology – Prospective epidemiological study in employees and patients of a dermatological department of a university hospital. J Dtsch Dermatol Ges 8:607–613

    PubMed  Google Scholar 

  60. 60.

    Pohle M, Bär W, Bühling A et al (2012) Untersuchung der MRSA-Prävalenz in der Bevölkerung im Bereich des lokalen MRE-Netzwerkes Südbrandenburg. Epidemiol Bull 8:63–67

    Google Scholar 

  61. 61.

    Herrmann M, Petit C, Dawson A et al (2013) Methicillin-resistant Staphylococcus aureus in Saarland, Germany: a statewide admission prevalence screening study. PloS One 8:e73876

    CAS  PubMed  PubMed Central  Google Scholar 

  62. 62.

    Chaberny IF, Bindseil A, Sohr D et al (2008) A point-prevalence study for MRSA in a German university hospital to identify patients at risk and to evaluate an established admission screening procedure. Infection 36:526–532

    PubMed  Google Scholar 

  63. 63.

    Popp W, Ross B, Raffenberg M et al (2012) Sektorenübergreifende MRSA-Eintagesprävalenzen – Erfahrungen aus Essen. Epidemiol Bull 27:249–251

    Google Scholar 

  64. 64.

    Woltering R, Hoffmann G, Daniels-Haardt I et al (2008) Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in patients in long-term care in hospitals, rehabilitation centers and nursing homes of a rural district in Germany. Dtsch Med Wochenschr 133:999–1003

    CAS  PubMed  Google Scholar 

  65. 65.

    Kramer A, Ryll S, Wegner C et al (2011) One-day point prevalence of emerging bacterial pathogens in four secondary and five tertiary care German hospitals – results from a pilot study of the German Society for Hospital Hygiene (Deutsche Gesellschaft fur Krankenhaushygiene, DGKH). GMS Krankenhhyg Interdiszip 6:Doc20

  66. 66.

    Wegner C, Hübner N, Gleich S et al (2013) One-day point prevalence of emerging bacterial pathogens in a nationwide sample of 62 German hospitals in 2012 and comparison with the results of the one-day point prevalence of 2010. GMS Hyg Infect Control 8:Doc12

  67. 67.

    Chaberny IF, Behrends H-BM, Höpken EW et al (2011) Prevalence and risk factors for carriage of methicillin-resistant Staphylococcus aureus (MRSA) in 17 German hospitals: results of a point-prevalence study in the rural district Hannover. Int J Med Microbiol 301:1–126

  68. 68.

    Kresken M, Hafner D, Körber-Irrgang B (2013) Abschlussbericht – Teilprojekt H. Epidemiologie und Resistenzsituation bei klinisch wichtigen Infektionserregern aus dem Hospitalbereich gegenüber Antibiotika. Bericht über die Ergebnisse einer multizentrischen Studie der Paul-Ehrlich-Gesellschaft für Chemotherapie e.V. aus dem Jahre 2010. Antiinfectives Intelligence, Rheinbach

  69. 69.

    Mielke M, Bölt U, Geffers C (2010) Basisdaten der stationären Krankenversorgung in Deutschland – nosokomiale Infektionen. Epidemiol Bull 36:359–368

    Google Scholar 

  70. 70.

    Nationales Referenzzentrum für Surveillance von nosokomialen Infektionen. www.nrz-hygiene.de. Zugegriffen: April 2014

  71. 71.

    Geschäftsstelle Qualitätssicherung im Krankenhaus (GeQiK) (2014). http://www.geqik.de/index.php?id=943. Zugegriffen: April 2014

  72. 72.

    Robert Koch-Institut, SurvStat (Abfrage der Meldedaten nach Infektionsschutzgesetz (IfSG) über das Web). http://www3.rki.de/SurvStat/. Zugegriffen: April 2014

  73. 73.

    Friedrich A, Köck R, Jurke A et al (2011) MRSA in Rehakliniken in der EUREGIO. 9. Ulmer Symposium Krankenhausinfektionen Kongressband. mhp Verlag GmbH, Wiesbaden. S 61–62

  74. 74.

    Köck R, Winner K, Schaumburg F et al (2014) Admission prevalence and acquisition of nasal carriage of methicillin-resistant Staphylococcus aureus (MRSA) in German rehabilitation centres. J Hosp Infect (im Druck)

  75. 75.

    Aizen E, Ljubuncic Z, Ljubuncic P et al (2007) Risk factors for methicillin-resistant Staphylococcus aureus colonization in a geriatric rehabilitation hospital. J Gerontol A Biol Sci Med Sci 62:1152–1156

  76. 76.

    Lauster F, Grosch I (2005) Die MRSA-Problematik in der Neurologischen Frührehabilitation. Hyg Med 30:332–335

    Google Scholar 

  77. 77.

    Anguelov A, Giraud K, Akpabie A et al (2010) Predictive factors of acquired methicillin-resistant Staphylococcus aureus in a rehabilitation care unit. Méd Mal Infect 40:677–682

  78. 78.

    Girou E, Legrand P, Soing-Altrach S et al (2006) Association between hand hygiene compliance and methicillin-resistant Staphylococcus aureus prevalence in a French rehabilitation hospital. Infect Control Hosp Epidemiol 27:1128–1130

    PubMed  Google Scholar 

  79. 79.

    Bilavsky E, Lerman Y, Rabinovich A et al (2012) Carriage of methicillin-resistant Staphylococcus aureus on admission to European rehabilitation centres – a prospective study. Clin Microbiol Infect 18:E164–E169

    CAS  PubMed  Google Scholar 

  80. 80.

    Pfingsten-Würzburg S, Pieper DH, Bautsch W et al (2011) Prevalence and molecular epidemiology of methicillin-resistant Staphylococcus aureus in nursing home residents in northern Germany. J Hosp Infect 78:108–112

    CAS  PubMed  Google Scholar 

  81. 81.

    Gruber I, Heudorf U, Werner G et al (2013) Multidrug-resistant bacteria in geriatric clinics, nursing homes, and ambulant care – prevalence and risk factors. Int J Med Microbiol 303:405–409

    PubMed  Google Scholar 

  82. 82.

    Heuck D, Witte W (2003) Methicillin-resistente Staphylococcus aureus (MRSA) in deutschen Alten- und Pflegeheimen – Zur Situation. Epidemiol Bull 19:145–148

    Google Scholar 

  83. 83.

    von Baum HS, Svoboda D et al (2002) Risk factors for methicillin-resistant Staphylococcus aureus carriage in residents of German nursing homes. Infect Control Hosp Epidemiol 23:511–515

    Google Scholar 

  84. 84.

    Neuhaus B, Bocter N, Braulke C et al (2002) Studie zum Vorkommen von Methicillin-resistenten Staphylococcus aureus in Alten- und Altenpflegeheimen in Nordrhein-Westfalen. Bundesgesundheitsblatt 45:894–904

    Google Scholar 

  85. 85.

    Heudorf U, Gustav C, Mischler D et al (2014) Nosokomiale Infektionen, systemischer Antibiotikaeinsatz und multiresistente Erreger bei Bewohnern von Altenpflegeheimen – das Frankfurter HALT-plus MRE-Projekt. Bundesgesundheitsblatt 57:414–422

    CAS  Google Scholar 

  86. 86.

    O’Sullivan NP, Keane CT (2000) Risk factors for colonization with methicillin-resistant Staphylococcus aureus among nursing home residents. J Hosp Infect 45:206–210

    PubMed  Google Scholar 

  87. 87.

    Cretnik TZ, Vovko P, Retelj M et al (2005) Prevalence and nosocomial spread of methicillin-resistant Staphylococcus aureus in a long-term-care facility in Slovenia. Infect Control Hosp Epidemiol 26:184–190

    PubMed  Google Scholar 

  88. 88.

    Denis O, Jans B, Deplano A et al (2009) Epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) among residents of nursing homes in Belgium. J Antimicrob Chemother 64:1299–1306

    CAS  PubMed  Google Scholar 

  89. 89.

    Manzur A, Gavalda L, Ruiz de Gopegui E et al (2008) Prevalence of methicillin-resistant Staphylococcus aureus and factors associated with colonization among residents in community long-term-care facilities in Spain. Clin Microbiol Infect 14:867–872

    CAS  PubMed  Google Scholar 

  90. 90.

    Brugnaro P, Fedeli U, Pellizzer G et al (2009) Clustering and risk factors of methicillin-resistant Staphylococcus aureus carriage in two Italian long-term care facilities. Infection 37:216–221

    CAS  PubMed  Google Scholar 

  91. 91.

    Barr B, Wilcox MH, Brady A et al (2007) Prevalence of methicillin-resistant Staphylococcus aureus colonization among older residents of care homes in the United Kingdom. Infect Control Hosp Epidemiol 28:853–859

    PubMed  Google Scholar 

  92. 92.

    Baldwin NS, Gilpin DF, Hughes CM et al (2009) Prevalence of methicillin-resistant Staphylococcus aureus colonization in residents and staff in nursing homes in Northern Ireland. J Am Geriatr Soc 57:620–626

    PubMed  Google Scholar 

  93. 93.

    Mossong J, Gelhausen E, Decruyenaere F et al (2013) Prevalence, risk factors and molecular epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) colonization in residents of long-term care facilities in Luxembourg. Epidemiol Infect 141:1199–1206

    CAS  PubMed  Google Scholar 

  94. 94.

    Greenland K, Rijnders MI, Mulders M et al (2011) Low prevalence of methicillin-resistant Staphylococcus aureus in Dutch nursing homes. J Am Geriatr Soc 59:768–769

    PubMed  Google Scholar 

  95. 95.

    Andersson H, Lindholm C, Iversen A et al (2012) Prevalence of antibiotic-resistant bacteria in residents of nursing homes in a Swedish municipality: healthcare staff knowledge of and adherence to principles of basic infection prevention. Scand J Infect Dis 44:641–649

    PubMed  Google Scholar 

  96. 96.

    Trick WE, Weinstein RA, DeMarais PL et al (2001) Colonization of skilled-care facility residents with antimicrobial-resistant pathogens. J Am Geriatr Soc 49:270–276

    CAS  PubMed  Google Scholar 

  97. 97.

    O’Fallon E, Pop-Vicas A, D’Agata E (2009) The emerging threat of multidrug-resistant gram-negative organisms in long-term care facilities. J Gerontol A Biol Sci Med Sci 64:138–141

    PubMed  Google Scholar 

  98. 98.

    Pop-Vicas A, Mitchell SL, Kandel R et al (2008) Multidrug-resistant gram-negative bacteria in a long-term care facility: prevalence and risk factors. J Am Geriatr Soc 56:1276–1280

    PubMed  Google Scholar 

  99. 99.

    Reynolds C, Quan V, Kim D et al (2011) Methicillin-resistant Staphylococcus aureus (MRSA) carriage in 10 nursing homes in Orange County, California. Infect Control Hosp Epidemiol 32:91–93

    PubMed  Google Scholar 

  100. 100.

    Safdar N, Maki DG (2002) The commonality of risk factors for nosocomial colonization and infection with antimicrobial-resistant Staphylococcus aureus, enterococcus, gram-negative bacilli, Clostridium difficile, and Candida. Ann Intern Med 136:834–844

    PubMed  Google Scholar 

  101. 101.

    Stone ND, Lewis DR, Lowery HK et al (2008) Importance of bacterial burden among methicillin-resistant Staphylococcus aureus carriers in a long-term care facility. Infect Control Hosp Epidemiol 29:143–148

    PubMed  Google Scholar 

  102. 102.

    Suetens C, Niclaes L, Jans B et al (2007) Determinants of methicillin-resistant Staphylococcus aureus carriage in nursing homes. Age Ageing 36:327–330

    PubMed  Google Scholar 

  103. 103.

    Daeschlein G, Assadian O, Rangous I et al (2006) Risk factors for Staphylococcus aureus nasal carriage in residents of three nursing homes in Germany. J Hosp Infect 63:216–220

    CAS  PubMed  Google Scholar 

  104. 104.

    Mody L, Kauffman CA, Donabedian S et al (2008) Epidemiology of Staphylococcus aureus colonization in nursing home residents. Clin Infect Dis 46:1368–1373

    PubMed  PubMed Central  Google Scholar 

  105. 105.

    Eveillard M, Charru P, Rufat P et al (2008) Methicillin-resistant Staphylococcus aureus carriage in a long-term care facility: hypothesis about selection and transmission. Age Ageing 37:294–299

    PubMed  Google Scholar 

  106. 106.

    Dancer SJ (2001) The problem with cephalosporins. J Antimicrob Chemother 48:463–478

    CAS  PubMed  Google Scholar 

  107. 107.

    Flannery EL, Wang L, Zollner S et al (2011) Wounds, functional disability, and indwelling devices are associated with cocolonization by methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci in southeast Michigan. Clin Infect Dis 53:1215–1222

    PubMed  PubMed Central  Google Scholar 

  108. 108.

    Dasenbrook EC (2011) Update on methicillin-resistant Staphylococcus aureus in cystic fibrosis. Curr Opin Pulm Med 17:437–441

    CAS  PubMed  Google Scholar 

  109. 109.

    Simon A, Schmitt-Grohe S, Erdmann U et al (2012) Anforderungen an die Hygiene bei der medizinischen Versorgung von Patienten mit Cystischer Fibrose (Mukoviszidose) – unter Beteiligung der DGPI, der Arbeitsgemeinschaft Mukoviszidose der GPP sowie der DGKJ, 1. Aufl. mhp, Homburg

    Google Scholar 

  110. 110.

    Dawson A, Mischler D, Petit C et al (2012) Prevalence of methicillin-resistant Staphylococcus aureus in end stage renal failure patients in Saarland and Hessen, Abstract. Intern J Med Microbiol 302:87

  111. 111.

    Lederer SR, Riedelsdorf G, Schiffl H (2007) Nasal carriage of methicillin-resistant Staphylococcus aureus: the prevalence, patients at risk and the effect of elimination on outcomes among outclinic haemodialysis patients. Eur J Med Res 12:284–288

    CAS  PubMed  Google Scholar 

  112. 112.

    Curtin J, Dalziel C (2010) Beat those bugs! Implementing contact precautions in community dialysis units for closer-to-home care. Can J Infect Control 25:9–16

    PubMed  Google Scholar 

  113. 113.

    Marchaim D, Lazarovitch Z, Efrati S et al (2005) Serious consequences to the use of cephalosporins as the first line of antimicrobial therapy administered in hemodialysis units. Nephron Clin Pract 101:c58–c64

  114. 114.

    Saxena AK, Panhotra BR, Al-hafiz AA et al (2012) Cefotaxime-heparin lock prophylaxis against hemodialysis catheter-related sepsis among Staphylococcus aureus nasal carriers. Saudi J Kidney Dis Transpl 23:743–754

    PubMed  Google Scholar 

  115. 115.

    Lu PL, Tsai JC, Chiu YW et al (2008) Methicillin-resistant Staphylococcus aureus carriage, infection and transmission in dialysis patients, healthcare workers and their family members. Nephrol Dial Transplant 23:1659–1665

    PubMed  Google Scholar 

  116. 116.

    Lai CF, Liao CH, Pai MF et al (2011) Nasal carriage of methicillin-resistant Staphylococcus aureus is associated with higher all-cause mortality in hemodialysis patients. Clin J Am Soc Nephrol 6:167–174

    PubMed  PubMed Central  Google Scholar 

  117. 117.

    Kang YC, Tai WC, Yu CC et al (2012) Methicillin-resistant Staphylococcus aureus nasal carriage among patients receiving hemodialysis in Taiwan: prevalence rate, molecular characterization and decolonization. BMC Infect Dis 12:284

    PubMed  PubMed Central  Google Scholar 

  118. 118.

    Koseoglu O, Sayin Kutlu S, Cevahir N (2012) Prevalence and risk factors for methicillin-resistant Staphylococcus aureus colonization among outpatients undergoing hemodialysis treatment. Mikrobiyol Bul 46:106–112

    PubMed  Google Scholar 

  119. 119.

    Hadley AC, Karchmer TB, Russell GB et al (2007) The prevalence of resistant bacterial colonization in chronic hemodialysis patients. Am J Nephrol 27:352–359

    PubMed  Google Scholar 

  120. 120.

    Pop-Vicas A, Strom J, Stanley K et al (2008) Multidrug-resistant gram-negative bacteria among patients who require chronic hemodialysis. Clin J Am Soc Nephrol 3:752–758

    CAS  PubMed  PubMed Central  Google Scholar 

  121. 121.

    Johnson LB, Jose J, Yousif F et al (2009) Prevalence of colonization with community-associated methicillin-resistant Staphylococcus aureus among end-stage renal disease patients and healthcare workers. Infect Control Hosp Epidemiol 30:4–8

    PubMed  Google Scholar 

  122. 122.

    Patel G, Jenkins SG, Mediavilla JR et al (2011) Clinical and molecular epidemiology of methicillin-resistant Staphylococcus aureus among patients in an ambulatory hemodialysis center. Infect Control Hosp Epidemiol 32:881–888

    PubMed  Google Scholar 

  123. 123.

    Köck R, Werner P, Friedrich A et al (2012) Characteristics of Staphylococcus aureus nasal carriage, resistance patterns and genetic lineages in healthy german adults. In: 52nd interscience conference on antimicrobial agents and chemotherapy, San Francisco, USA. American Society for Microbiology, Washington

  124. 124.

    David MZ, Daum RS (2010) Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic. Clin Microbiol Rev 23:616–687

    CAS  PubMed  PubMed Central  Google Scholar 

  125. 125.

    Witte W, Strommenger B, Cuny C et al (2007) Methicillin-resistant Staphylococcus aureus containing the Panton-Valentine leucocidin gene in Germany in 2005 and 2006. J Antimicrob Chemother 60:1258–1263

    CAS  PubMed  Google Scholar 

  126. 126.

    Köck R, Mellmann A, Schaumburg F et al (2011) The epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) in Germany. Dtsch Ärztebl Int 108:761–767

  127. 127.

    Thurman AR, Anca Y, White CA et al (2010) Post-cesarean delivery infectious morbidity: focus on preoperative antibiotics and methicillin-resistant Staphylococcus aureus. Am J Infect Control 38:612–616

    PubMed  Google Scholar 

  128. 128.

    Stafford I, Hernandez J, Laibl V et al (2008) Community-acquired methicillin-resistant Staphylococcus aureus among patients with puerperal mastitis requiring hospitalization. Obstet Gynecol 112:533–537

    PubMed  Google Scholar 

  129. 129.

    Beigi RH, Bunge K, Song Y et al (2009) Epidemiologic and economic effect of methicillin-resistant Staphylococcus aureus in obstetrics. Obstet Gynecol 113:983–991

    PubMed  Google Scholar 

  130. 130.

    Branch-Elliman W, Golen TH, Gold HS et al (2012) Risk factors for Staphylococcus aureus postpartum breast abscess. Clin Infect Dis 54:71–77

    PubMed  Google Scholar 

  131. 131.

    Laibl VR, Sheffield JS, Roberts S et al (2005) Clinical presentation of community-acquired methicillin-resistant Staphylococcus aureus in pregnancy. Obstet Gynecol 106:461–465

    PubMed  Google Scholar 

  132. 132.

    Gray J, Patwardhan SC, Martin W (2010) Methicillin-resistant Staphylococcus aureus screening in obstetrics: a review. J Hosp Infect 75:89–92

    CAS  PubMed  Google Scholar 

  133. 133.

    Lucet JC, Regnier B (2010) Screening and decolonization: does methicillin-susceptible Staphylococcus aureus hold lessons for methicillin-resistant S. aureus? Clin Infect Dis 51:585–590

    PubMed  Google Scholar 

  134. 134.

    Tübbicke A, Hübner C, Kramer A et al (2012) Transmission rates, screening methods and costs of MRSA – a systematic literature review related to the prevalence in Germany. Eur J Clin Microbiol Infect Dis 31:2497–2511

  135. 135.

    Patel RI, Kaufman HK (2011) Nasopharyngeal carriage of methicillin-resistant Staphylococcus aureus: incidence and outcomes in pregnant women. J Am Osteopath Assoc 111:389–395

    PubMed  Google Scholar 

  136. 136.

    Andrews WW, Schelonka R, Waites K et al (2008) Genital tract methicillin-resistant Staphylococcus aureus: risk of vertical transmission in pregnant women. Obstet Gynecol 111:113–118

    PubMed  Google Scholar 

  137. 137.

    Chen KT, Huard RC, Della-Latta P et al (2006) Prevalence of methicillin-sensitive and methicillin-resistant Staphylococcus aureus in pregnant women. Obstet Gynecol 108:482–487

    PubMed  Google Scholar 

  138. 138.

    Top KA, Huard RC, Fox Z et al (2010) Trends in methicillin-resistant Staphylococcus aureus anovaginal colonization in pregnant women in 2005 versus 2009. J Clin Microbiol 48:3675–3680

    CAS  PubMed  PubMed Central  Google Scholar 

  139. 139.

    Lazenby GB, Soper DE, Beardsley W et al (2012) Methicillin-resistant Staphylococcus aureus colonization among women admitted for preterm delivery. Am J Obstet Gynecol 206(329):e321–e325

    Google Scholar 

  140. 140.

    Creech CB, Litzner B, Talbot TR et al (2010) Frequency of detection of methicillin-resistant Staphylococcus aureus from rectovaginal swabs in pregnant women. Am J Infect Control 38:72–74

    PubMed  Google Scholar 

  141. 141.

    Huang YC, Chao AS, Chang SD et al (2009) Association of Staphylococcus aureus colonization in parturient mothers and their babies. Pediatr Infect Dis J 28:742–744

    PubMed  Google Scholar 

  142. 142.

    Tomlinson MW, Schmidt NM, Rourke JW Jr et al (2011) Rectovaginal Staphylococcus aureus colonization: is it a neonatal threat? Am J Perinatol 28:673–676

  143. 143.

    Jimenez-Truque N, Tedeschi S, Saye EJ et al (2012) Relationship between maternal and neonatal Staphylococcus aureus colonization. Pediatrics 129:e1252–e1259

    PubMed  PubMed Central  Google Scholar 

  144. 144.

    Ghanim N, Alchyib O, Morrish D et al (2011) Maternal-neonatal outcome with Staphylococcus aureus rectovaginal colonization. J Reprod Med 56:421–424

    PubMed  Google Scholar 

  145. 145.

    Pinter DM, Mandel J, Hulten KG et al (2009) Maternal-infant perinatal transmission of methicillin-resistant and methicillin-sensitive Staphylococcus aureus. Am J Perinatol 26:145–151

    PubMed  Google Scholar 

  146. 146.

    Reusch M, Ghosh P, Ham C et al (2008) Prevalence of MRSA colonization in peripartum mothers and their newborn infants. Scand J Infect Dis 40:667–671

    PubMed  Google Scholar 

  147. 147.

    Albrich WC, Harbarth S (2008) Health-care workers: source, vector, or victim of MRSA? Lancet Infect Dis 8:289–301

    PubMed  Google Scholar 

  148. 148.

    Dietze B, Rath A, Rüden H (1996) Kann durch die Einhaltung strikter Hygienemaßnahmen und umfassende Personaluntersuchungen eine MRSA-Epidemie beendet werden? Hyg Med 21:412–423

    Google Scholar 

  149. 149.

    Kaminski A, Kammler J, Wick M et al (2007) Transmission of methicillin-resistant Staphylococcus aureus among hospital staff in a German trauma centre: a problem without a current solution? J Bone Joint Surg Br 89:642–645

    CAS  PubMed  Google Scholar 

  150. 150.

    Kampf G, Adena S, Rüden H et al (2003) Inducibility and potential role of mecA-gene-positive oxacillin-susceptible Staphylococcus aureus from colonized healthcare workers as a source for nosocomial infections. J Hosp Infect 54:124–129

    CAS  PubMed  Google Scholar 

  151. 151.

    Witte W, Mielke M, Ammon A et al (2005) Fachtagung der AG Nosokomiale Infektionen am RKI zur Intensivierung der Umsetzung von Präventionsstrategien bei MRSA. Epidemiol Bull 5:31–38

    Google Scholar 

  152. 152.

    Joos AK (2009) MRSA-Personalscreening in einer Chirurgischen Universitätsklinik. Hyg Med 34:183–187

    Google Scholar 

  153. 153.

    Saßmannshausen R (2012) Prävalenz und Sanierung von Methicillin-resistenten Staphylococcus aureus (MRSA) bei Klinikpersonal im deutschen Teil des EUREGIO-Gebietes. Westfälische Wilhelms-Universität Münster, Münster

  154. 154.

    Bundesinstitut für Risikobewertung (BfR) (2009) Molekularbiologische Charakterisierung und Quantifizierung von Methicillin-resistenten Staphylococcus aureus (MRSA) aus landwirtschaftlichen Nutztieren und vom Tier stammenden Lebensmitteln, Vorläufiger Abschlussbericht (Förderkennzeichen 2808HS032). BfR, Berlin

  155. 155.

    Köck R, Loth B, Koksal M et al (2012) Persistence of nasal colonization with livestock-associated methicillin-resistant Staphylococcus aureus in pig farmers after holidays from pig exposure. Appl Environ Microbiol 78:4046–4047

    PubMed  PubMed Central  Google Scholar 

  156. 156.

    Cuny C, Nathaus R, Layer F et al (2009) Nasal colonization of humans with methicillin-resistant Staphylococcus aureus (MRSA) CC398 with and without exposure to pigs. PloS One 4:e6800

    PubMed  PubMed Central  Google Scholar 

  157. 157.

    Bisdorff B, Scholholter JL, Claussen K et al (2012) MRSA-ST398 in livestock farmers and neighbouring residents in a rural area in Germany. Epidemiol Infect 140:1800–1808

    CAS  PubMed  Google Scholar 

  158. 158.

    Cuny C, Friedrich A, Kozytska S et al (2010) Emergence of methicillin-resistant Staphylococcus aureus (MRSA) in different animal species. Int J Med Microbiol 300:109–117

    PubMed  Google Scholar 

  159. 159.

    Witte W, Strommenger B, Stanek C et al (2007) Methicillin-resistant Staphylococcus aureus ST398 in humans and animals, Central Europe. Emerg Infect Dis 13:255–258

    CAS  PubMed  PubMed Central  Google Scholar 

  160. 160.

    Köck R (2013) Livestock-associated methicillin-resistant Staphylococcus aureus (MRSA) as causes of human infection and colonization in Germany. PloS One 8:e55040

    PubMed  PubMed Central  Google Scholar 

  161. 161.

    Walther B, Wieler LH, Friedrich AW et al (2008) Methicillin-resistant Staphylococcus aureus (MRSA) isolated from small and exotic animals at a university hospital during routine microbiological examinations. Vet Microbiol 127:171–178

    CAS  PubMed  Google Scholar 

  162. 162.

    Nienhoff U (2009) Transmission of methicillin-resistant Staphylococcus aureus strains between humans and dogs: two case reports. J Antimicrob Chemother 64:660–662

    CAS  PubMed  Google Scholar 

  163. 163.

    Wagenvoort JH, De Brauwer EI, Sijstermans ML et al (2005) Risk of re-introduction of methicillin-resistant Staphylococcus aureus into the hospital by intrafamilial spread from and to healthcare workers. J Hosp Infect 59:67–68

    CAS  PubMed  Google Scholar 

  164. 164.

    Portigliatti Barbos MM, Pecoraro S et al (2010) Decolonization of orthopedic surgical team S. aureus carriers: impact on surgical-site infections. J Orthop Traumatol 11:47–49

  165. 165.

    Gurieva TV, Bootsma MC, Bonten MJ (2012) Decolonization of patients and health care workers to control nosocomial spread of methicillin-resistant Staphylococcus aureus: a simulation study. BMC Infect Dis 12:302

    PubMed  PubMed Central  Google Scholar 

  166. 166.

    Witte W, Cuny C, Braulke C et al (1997) Widespread dissemination of epidemic MRSA in German hospitals. Euro Surveill 2:25–28

    PubMed  Google Scholar 

  167. 167.

    Laine J, Huttunen R, Vuento R et al (2013) Methicillin-resistant Staphylococcus aureus epidemic restricted to one health district in Finland: a population-based descriptive study in Pirkanmaa, Finland, years 2001–2011. Scand J Infect Dis 45:45–53

    PubMed  Google Scholar 

  168. 168.

    Sexton T, Clarke P, O’Neill E et al (2006) Environmental reservoirs of methicillin-resistant Staphylococcus aureus in isolation rooms: correlation with patient isolates and implications for hospital hygiene. J Hosp Infect 62:187–194

    CAS  PubMed  Google Scholar 

  169. 169.

    Kramer A, Schwebke I, Kampf G (2006) How long do nosocomial pathogens persist on inanimate surfaces? A systematic review. BMC Infect Dis 6:130

    PubMed  PubMed Central  Google Scholar 

  170. 170.

    Dancer SJ, White LF, Lamb J et al (2009) Measuring the effect of enhanced cleaning in a UK hospital: a prospective cross-over study. BMC Med 7:28

    PubMed  PubMed Central  Google Scholar 

  171. 171.

    Boyce JM (2007) Environmental contamination makes an important contribution to hospital infection. J Hosp Infect 65(Suppl 2):50–54

    PubMed  Google Scholar 

  172. 172.

    von Eiff CB, Machka K et al (2001) Nasal carriage as a source of Staphylococcus aureus bacteremia. Study Group. N Engl J Med 344:11–16

    Google Scholar 

  173. 173.

    Hübner NO, Thanheiser M (2013) Infection prevention in surgical and endoscopic procedures. Gastrointest Med Surg 29:166–173

    Google Scholar 

  174. 174.

    Pittet D, Hugonnet S, Harbarth S et al (2000) Effectiveness of a hospital-wide programme to improve compliance with hand hygiene. Infection Control Programme. Lancet 356:1307–1312

    CAS  PubMed  Google Scholar 

  175. 175.

    Lai KK, Fontecchio S, Melvin Z et al (2006) Impact of alcohol-based, waterless hand antiseptic on the incidence of infection and colonization with methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci. Infect Control Hosp Epidemiol 27:1018–1024

    PubMed  Google Scholar 

  176. 176.

    Sherertz RJ, Reagan DR, Hampton KD et al (1996) A cloud adult: the Staphylococcus aureus-virus interaction revisited. Ann Intern Med 124:539–547

    CAS  PubMed  Google Scholar 

  177. 177.

    Bassetti S, Bischoff WE, Walter M et al (2005) Dispersal of Staphylococcus aureus into the air associated with a rhinovirus infection. Infect Control Hosp Epidemiol 26:196–203

    PubMed  Google Scholar 

  178. 178.

    Sherertz RJ, Bassetti S, Bassetti-Wyss B (2001) „Cloud“ health-care workers. Emerg Infect Dis 7:241–244

    CAS  PubMed  PubMed Central  Google Scholar 

  179. 179.

    Subirana M, Sola I, Benito S (2007) Closed tracheal suction systems versus open tracheal suction systems for mechanically ventilated adult patients. Cochrane Database Syst Rev (4):CD004581

  180. 180.

    Ricard JD, Eveillard M, Martin Y et al (2011) Influence of tracheal suctioning systems on health care workers’ gloves and equipment contamination: a comparison of closed and open systems. Am J Infect Control 39:605–607

    PubMed  Google Scholar 

  181. 181.

    Shiomori T, Miyamoto H, Makishima K et al (2002) Evaluation of bedmaking-related airborne and surface methicillin-resistant Staphylococcus aureus contamination. J Hosp Infect 50:30–35

    CAS  PubMed  Google Scholar 

  182. 182.

    Eames I, Tang JW, Li Y et al (2009) Airborne transmission of disease in hospitals. J R Soc Interface 6(Suppl 6):S697–S702

  183. 183.

    Berman DS, Schaefler S, Simberkoff MS et al (1986) Tourniquets and nosocomial methicillin-resistant Staphylococcus aureus infections. N Engl J Med 315:514–515

    CAS  PubMed  Google Scholar 

  184. 184.

    Cohen HA, Amir J, Matalon A et al (1997) Stethoscopes and otoscopes – a potential vector of infection? Fam Pract 14:446–449

    CAS  PubMed  Google Scholar 

  185. 185.

    Bures S, Fishbain JT, Uyehara CF et al (2000) Computer keyboards and faucet handles as reservoirs of nosocomial pathogens in the intensive care unit. Am J Infect Control 28:465–471

    CAS  PubMed  Google Scholar 

  186. 186.

    Dancer SJ (2008) Importance of the environment in methicillin-resistant Staphylococcus aureus acquisition: the case for hospital cleaning. Lancet Infect Dis 8:101–113

    PubMed  Google Scholar 

  187. 187.

    Treakle AM, Thom KA, Furuno JP et al (2009) Bacterial contamination of health care workers’ white coats. Am J Infect Control 37:101–105

    PubMed  PubMed Central  Google Scholar 

  188. 188.

    Hübner NO, Flessa S, Haak J et al (2011) Can the Hazard Assessment and Critical Control Points (HACCP) system be used to design process-based hygiene concepts? GMS Krankenhhyg Interdiszip 6:Doc24

  189. 189.

    Ajao AO, Harris AD, Roghmann MC et al (2011) Systematic review of measurement and adjustment for colonization pressure in studies of methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and Clostridium difficile acquisition. Infect Control Hosp Epidemiol 32:481–489

    PubMed  PubMed Central  Google Scholar 

  190. 190.

    Colbeck JC (1960) Environmental aspects of staphylococcal infections acquired in hospitals. I. The hospital environment – its place in the hospital Staphylococcus infections problem. Am J Public Health Nations Health 50:468–473

  191. 191.

    Wang J, Wang M, Huang Y et al (2011) Colonization pressure adjusted by degree of environmental contamination: a better indicator for predicting methicillin-resistant Staphylococcus aureus acquisition. Am J Infect Control 39:763–769

    PubMed  Google Scholar 

  192. 192.

    Moore C, Dhaliwal J, Tong A et al (2008) Risk factors for methicillin-resistant Staphylococcus aureus (MRSA) acquisition in roommate contacts of patients colonized or infected with MRSA in an acute-care hospital. Infect Control Hosp Epidemiol 29:600–606

    PubMed  Google Scholar 

  193. 193.

    White A (1961) Quantitative studies of nasal carriers of staphylococci among hospitalized patients. J Clin Invest 40:23–30

    CAS  PubMed  PubMed Central  Google Scholar 

  194. 194.

    Vonberg RP, Stamm-Balderjahn S, Hansen S et al (2006) How often do asymptomatic healthcare workers cause methicillin-resistant Staphylococcus aureus outbreaks? A systematic evaluation. Infect Control Hosp Epidemiol 27:1123–1127

    PubMed  Google Scholar 

  195. 195.

    Watanabe H, Masaki H, Asoh N et al (2000) Molecular analysis of methicillin-resistant Staphylococcus aureus as a causative agent of bronchopulmonary infection: relation to colonization in the upper respiratory tract. J Clin Microbiol 38:3867–3869

    CAS  PubMed  PubMed Central  Google Scholar 

  196. 196.

    Cepeda JA, Whitehouse T, Cooper B et al (2005) Isolation of patients in single rooms or cohorts to reduce spread of MRSA in intensive-care units: prospective two-centre study. Lancet 365:295–304

    PubMed  Google Scholar 

  197. 197.

    Cataldo MA, Taglietti F, Petrosillo N (2010) Methicillin-resistant Staphylococcus aureus: a community health threat. Postgrad Med 122:16–23

    PubMed  Google Scholar 

  198. 198.

    Gastmeier P (2010) Healthcare-associated versus community-acquired infections: a new challenge for science and society. Int J Med Microbiol 300:342–345

    PubMed  Google Scholar 

  199. 199.

    Stone ND, Lewis DR, Johnson TM II et al (2012) Methicillin-resistant Staphylococcus aureus (MRSA) nasal carriage in residents of veterans affairs long-term care facilities: role of antimicrobial exposure and MRSA acquisition. Infect Control Hosp Epidemiol 33:551–557

  200. 200.

    Rosenthal VD, Maki DG, Jamulitrat S et al (2010) International Nosocomial Infection Control Consortium (INICC) report, data summary for 2003–2008, issued June 2009. Am J Infect Control 38:95–104

  201. 201.

    Robotham JV, Scarff CA, Jenkins DR et al (2007) Methicillin-resistant Staphylococcus aureus (MRSA) in hospitals and the community: model predictions based on the UK situation. J Hosp Infect 65(Suppl 2):93–99

    PubMed  Google Scholar 

  202. 202.

    Kajita E, Okano JT, Bodine EN et al (2007) Modelling an outbreak of an emerging pathogen. Nat Rev Microbiol 5:700–709

    CAS  PubMed  Google Scholar 

  203. 203.

    Cooper BS, Kypraios T, Batra R et al (2012) Quantifying type-specific reproduction numbers for nosocomial pathogens: evidence for heightened transmission of an Asian sequence type 239 MRSA clone. PLoS Comput Biol 8:e1002454

    CAS  PubMed  PubMed Central  Google Scholar 

  204. 204.

    Cooper BS, Medley GF, Stone SP et al (2004) Methicillin-resistant Staphylococcus aureus in hospitals and the community: stealth dynamics and control catastrophes. Proc Natl Acad Sci U S A 101:10223–10228

    CAS  PubMed  PubMed Central  Google Scholar 

  205. 205.

    Bootsma MC, Wassenberg MW, Trapman P et al (2011) The nosocomial transmission rate of animal-associated ST398 methicillin-resistant Staphylococcus aureus. J R Soc Interface 8:578–584

    PubMed  PubMed Central  Google Scholar 

  206. 206.

    Gurieva T, Bootsma MC, Bonten MJ (2012) Successful veterans affairs initiative to prevent methicillin-resistant Staphylococcus aureus infections revisited. Clin Infect Dis 54:1618–1620

    PubMed  Google Scholar 

  207. 207.

    Esveld MI, de Boer AS, Notenboom AJ et al (1999) Secondary infection with methicillin-resistant Staphylococcus aureus in Dutch hospitals (July 1997–June 1996). Ned Tijdschr Geneeskd 143:205–208

    CAS  PubMed  Google Scholar 

  208. 208.

    Martin U, Sonntag AK, Neuhaus B et al (2004) Surface disinfection in nursing homes – what is really happening? Study of control success in three Duisburg nursing homes. Gesundheitswesen 66:682–687

    CAS  PubMed  Google Scholar 

  209. 209.

    Hughes C, Smith M, Tunney M et al (2011) Infection control strategies for preventing the transmission of methicillin-resistant Staphylococcus aureus (MRSA) in nursing homes for older people. Cochrane Database Syst Rev (1):CD006354

  210. 210.

    Baldwin NS, Gilpin DF, Tunney MM et al (2010) Cluster randomised controlled trial of an infection control education and training intervention programme focusing on methicillin-resistant Staphylococcus aureus in nursing homes for older people. J Hosp Infect 76:36–41

    CAS  PubMed  Google Scholar 

  211. 211.

    Horner C, Wilcox M, Barr B et al (2012) The longitudinal prevalence of MRSA in care home residents and the effectiveness of improving infection prevention knowledge and practice on colonisation using a stepped wedge study design. BMJ Open 2:e000423

    CAS  PubMed  PubMed Central  Google Scholar 

  212. 212.

    Brown R, Minnon J, Schneider S et al (2010) Prevalence of methicillin-resistant Staphylococcus aureus in ambulances in southern Maine. Prehosp Emerg Care 14:176–181

    PubMed  Google Scholar 

  213. 213.

    Roline CE, Crumpecker C, Dunn TM (2007) Can methicillin-resistant Staphylococcus aureus be found in an ambulance fleet? Prehosp Emerg Care 11:241–244

    PubMed  Google Scholar 

  214. 214.

    Kober P, Labes H, Möller H et al (2000) Mikrobiologische Kontamination und Hygienemaßnahmen in Rettungswagen. Hyg Med 25:296–302

    Google Scholar 

  215. 215.

    Fischer D, Veldman A, Schäfer V et al (2004) Bacterial colonization of patients undergoing international air transport: a prospective epidemiologic study. J Travel Med 11:44–48

    PubMed  Google Scholar 

  216. 216.

    Ro YS, Shin SD, Noh H et al (2012) Prevalence of positive carriage of tuberculosis, methicillin-resistant Staphylococcus aureus, and vancomycin-resistant Enterococci in patients transported by ambulance: a single center observational study. J Prev Med Public Health 45:174–180

    PubMed  PubMed Central  Google Scholar 

  217. 217.

    Nigam Y, Cutter J (2003) A preliminary investigation into bacterial contamination of Welsh emergency ambulances. Emerg Med J 20:479–482

    CAS  PubMed  PubMed Central  Google Scholar 

  218. 218.

    Noh H, Shin SD, Kim NJ et al (2011) Risk stratification-based surveillance of bacterial contamination in metropolitan ambulances. J Korean Med Sci 26:124–130

    PubMed  PubMed Central  Google Scholar 

  219. 219.

    Groß R (2009) Analyse des Hygienestatus und des Personalschutzes im deutschen Rettungsdienst und Krankentransport. Dissertation. Med. Fakultät, Ernst-Moritz-Arndt-Universität Greifswald, Greifswald

  220. 220.

    Wildermuth S, Stahl W, Dirks B et al. (2012) Die Ulmer Secure Studie: Keimbelastung im Rettungsdienst. Vortrag DGKG, 2012. HygMed, 37-Supplement

  221. 221.

    Eibicht SJ, Vogel U (2011) Methicillin-resistant Staphylococcus aureus (MRSA) contamination of ambulance cars after short term transport of MRSA-colonised patients is restricted to the stretcher. J Hosp Infect 78:221–225

    CAS  PubMed  Google Scholar 

  222. 222.

    Erk G-O, Brandt C, Heudorf U (2013) Mikrobielle Belastung und multiresistente Erreger im qualifizierten und nichtqualifizierten Krankentransport. Hyg Med 38:23–29

    Google Scholar 

  223. 223.

    Davis MF, Iverson SA, Baron P et al (2012) Household transmission of methicillin-resistant Staphylococcus aureus and other staphylococci. Lancet Infect Dis 12:703–716

    PubMed  Google Scholar 

  224. 224.

    Mollema FP, Richardus JH, Behrendt M et al (2010) Transmission of methicillin-resistant Staphylococcus aureus to household contacts. J Clin Microbiol 48:202–207

    CAS  PubMed  PubMed Central  Google Scholar 

  225. 225.

    Johansson PJ, Gustafsson EB, Ringberg H (2007) High prevalence of MRSA in household contacts. Scand J Infect Dis 39:764–768

    PubMed  Google Scholar 

  226. 226.

    Niniou I, Vourli S, Lebessi E et al (2008) Clinical and molecular epidemiology of community-acquired, methicillin-resistant Staphylococcus aureus infections in children in central Greece. Eur J Clin Microbiol Infect Dis 27:831–837

    CAS  PubMed  Google Scholar 

  227. 227.

    Bundesverband für Tiergesundheit e.V. (BfT) (2013) Tierbestand in Deutschland 2011–2012 in Mio.. Tiergesundheit Blickpunkt 72:3

  228. 228.

    van Cleef BA, Graveland H, Haenen AP et al (2011) Persistence of livestock-associated methicillin-resistant Staphylococcus aureus in field workers after short-term occupational exposure to pigs and veal calves. J Clin Microbiol 49:1030–1033

    PubMed  PubMed Central  Google Scholar 

  229. 229.

    Graveland H, Wagenaar JA, Heesterbeek H et al (2010) Methicillin-resistant Staphylococcus aureus ST398 in veal calf farming: human MRSA carriage related with animal antimicrobial usage and farm hygiene. PloS One 5:e10990

    PubMed  PubMed Central  Google Scholar 

  230. 230.

    Alt K, Fetsch A, Schroeter A et al (2011) Factors associated with the occurrence of MRSA CC398 in herds of fattening pigs in Germany. BMC Vet Res 7:69

    CAS  PubMed  PubMed Central  Google Scholar 

  231. 231.

    Broens EM, Graat EA, Van der Wolf PJ et al (2011) Prevalence and risk factor analysis of livestock associated MRSA-positive pig herds in The Netherlands. Prev Vet Med 102:41–49

    CAS  PubMed  Google Scholar 

  232. 232.

    Hartung M, Käsbohrer A (2013) Erreger von Zoonosen in Deutschland im Jahr 2011.

  233. 233.

    Hartung M, Käsbohrer A (2011) Erreger von Zoonosen in Deutschland im Jahr 2009.

  234. 234.

    de Boer E, Zwartkruis-Nahuis JT, Wit B et al (2009) Prevalence of methicillin-resistant Staphylococcus aureus in meat. Int J Food Microbiol 134:52–56

  235. 235.

    Pu S, Han F, Ge B (2009) Isolation and characterization of methicillin-resistant Staphylococcus aureus strains from Louisiana retail meats. Appl Environ Microbiol 75:265–267

    CAS  PubMed  PubMed Central  Google Scholar 

  236. 236.

    Weese JS, Reid-Smith R, Rousseau J et al (2010) Methicillin-resistant Staphylococcus aureus (MRSA) contamination of retail pork. Can Vet J 51:749–752

    PubMed  PubMed Central  Google Scholar 

  237. 237.

    Cuny C, Layer F, Witte W (2011) Staphylococcus aureus and MRSA in thawing liquid of broiler chicken cacasses and their relation to clonal lineages from humans (Abstract ZOV01). Intern J Med Microbiol S1:117

  238. 238.

    Richter A, Sting R, Popp C et al (2012) Prevalence of types of methicillin-resistant Staphylococcus aureus in turkey flocks and personnel attending the animals. Epidemiol Infect 140:2223–2232

    CAS  PubMed  PubMed Central  Google Scholar 

  239. 239.

    Schulz J, Friese A, Klees S et al (2012) Longitudinal study of the contamination of air and of soil surfaces in the vicinity of pig barns by livestock-associated methicillin-resistant Staphylococcus aureus. Appl Environ Microbiol 78:5666–5671

    CAS  PubMed  PubMed Central  Google Scholar 

  240. 240.

    Strommenger B, Kehrenberg C, Kettlitz C et al (2006) Molecular characterization of methicillin-resistant Staphylococcus aureus strains from pet animals and their relationship to human isolates. J Antimicrob Chemother 57:461–465

    CAS  PubMed  Google Scholar 

  241. 241.

    Walther B, Wieler L, Friedrich A et al (2009) Staphylococcus aureus and MRSA colonization rates among personnels and dogs in a small animal hospital: association with nosocomial infections. Berl Munch Tierarztl Wochenschr 122:178–185

    PubMed  Google Scholar 

  242. 242.

    Walther B, Hermes J, Cuny C et al (2012) Sharing more than friendship – nasal colonization with coagulase-positive staphylococci (CPS) and co-habitation aspects of dogs and their owners. PloS One 7:e35197

    CAS  PubMed  PubMed Central  Google Scholar 

  243. 243.

    Kommission für Krankenhaushygiene und Infektionsprävention (KRINKO), Bundesinstitut für Arzneimittel und Medizinprodukte (BfArM) (2012) Anforderungen an die Hygiene bei der Aufbereitung von Medizinprodukten. Bundesgesundheitsblatt 55:1244–1310

    Google Scholar 

  244. 244.

    Kommision für Krankenhaushygiene und Infektionsprävention (2007) Anforderungen der Krankenhaushygiene und des Arbeitsschutzes an die Hygienebekleidung und persönliche Schutzausrüstung. Epidemiol Bull 1:3–4

    Google Scholar 

  245. 245.

    Eveillard M, Lancien E, Barnaud G et al (2005) Impact of screening for MRSA carriers at hospital admission on risk-adjusted indicators according to the imported MRSA colonization pressure. J Hosp Infect 59:254–258

    CAS  PubMed  Google Scholar 

  246. 246.

    Lucet JC, Paoletti X, Lolom I et al (2005) Successful long-term program for controlling methicillin-resistant Staphylococcus aureus in intensive care units. Intensive Care Med 31:1051–1057

    PubMed  Google Scholar 

  247. 247.

    Ellingson K, Muder RR, Jain R et al (2011) Sustained reduction in the clinical incidence of methicillin-resistant Staphylococcus aureus colonization or infection associated with a multifaceted infection control intervention. Infect Control Hosp Epidemiol 32:1–8

    PubMed  Google Scholar 

  248. 248.

    Holzmann-Pazgal G, Monney C, Davis K et al (2011) Active surveillance culturing impacts methicillin-resistant Staphylococcus aureus acquisition in a pediatric intensive care unit. Pediatr Crit Care Med 12:e171–e175

    PubMed  Google Scholar 

  249. 249.

    Reilly JS, Stewart S, Christie P et al (2012) Universal screening for methicillin-resistant Staphylococcus aureus in acute care: risk factors and outcome from a multicentre study. J Hosp Infect 80:31–35

    CAS  PubMed  Google Scholar 

  250. 250.

    Souweine B, Traore O, Aublet-Cuvelier B et al (2000) Role of infection control measures in limiting morbidity associated with multi-resistant organisms in critically ill patients. J Hosp Infect 45:107–116

    CAS  PubMed  Google Scholar 

  251. 251.

    Huang SS, Yokoe DS, Hinrichsen VL et al (2006) Impact of routine intensive care unit surveillance cultures and resultant barrier precautions on hospital-wide methicillin-resistant Staphylococcus aureus bacteremia. Clin Infect Dis 43:971–978

    PubMed  Google Scholar 

  252. 252.

    Shitrit P, Gottesman BS, Katzir M et al (2006) Active surveillance for methicillin-resistant Staphylococcus aureus (MRSA) decreases the incidence of MRSA bacteremia. Infect Control Hosp Epidemiol 27:1004–1008

    PubMed  Google Scholar 

  253. 253.

    Pan A, Carnevale G, Catenazzi P et al (2005) Trends in methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections: effect of the MRSA "search and isolate" strategy in a hospital in Italy with hyperendemic MRSA. Infect Control Hosp Epidemiol 26:127–133

    PubMed  Google Scholar 

  254. 254.

    Tomic V, Svetina Sorli P, Trinkaus D et al (2004) Comprehensive strategy to prevent nosocomial spread of methicillin-resistant Staphylococcus aureus in a highly endemic setting. Arch Intern Med 164:2038–2043

    PubMed  Google Scholar 

  255. 255.

    Wernitz MH, Swidsinski S, Weist K et al (2005) Effectiveness of a hospital-wide selective screening programme for methicillin-resistant Staphylococcus aureus (MRSA) carriers at hospital admission to prevent hospital-acquired MRSA infections. Clin Microbiol Infect 11:457–465

    CAS  PubMed  Google Scholar 

  256. 256.

    West TE, Guerry C, Hiott M et al (2006) Effect of targeted surveillance for control of methicillin-resistant Staphylococcus aureus in a community hospital system. Infect Control Hosp Epidemiol 27:233–238

    PubMed  Google Scholar 

  257. 257.

    Awad SS, Palacio CH, Subramanian A et al (2009) Implementation of a methicillin-resistant Staphylococcus aureus (MRSA) prevention bundle results in decreased MRSA surgical site infections. Am J Surg 198:607–610

    PubMed  Google Scholar 

  258. 258.

    Jog S, Cunningham R, Cooper S et al (2008) Impact of preoperative screening for methicillin-resistant Staphylococcus aureus by real-time polymerase chain reaction in patients undergoing cardiac surgery. J Hosp Infect 69:124–130

    CAS  PubMed  Google Scholar 

  259. 259.

    Keshtgar MR, Khalili A, Coen PG et al (2008) Impact of rapid molecular screening for methicillin-resistant Staphylococcus aureus in surgical wards. Br J Surg 95:381–386

    CAS  PubMed  Google Scholar 

  260. 260.

    Robicsek A, Beaumont JL, Paule SM et al (2008) Universal surveillance for methicillin-resistant Staphylococcus aureus in 3 affiliated hospitals. Ann Intern Med 148:409–418

    PubMed  Google Scholar 

  261. 261.

    Martinez-Capolino C, Reyes K, Johnson L et al (2010) Impact of active surveillance on methicillin-resistant Staphylococcus aureus transmission and hospital resource utilisation. J Hosp Infect 74:232–237

    CAS  PubMed  Google Scholar 

  262. 262.

    Chowers MY, Paitan Y, Gottesman BS et al (2009) Hospital-wide methicillin-resistant Staphylococcus aureus control program: a 5-year follow-up. Infect Control Hosp Epidemiol 30:778–781

    PubMed  Google Scholar 

  263. 263.

    Pofahl WE, Goettler CE, Ramsey KM et al (2009) Active surveillance screening of MRSA and eradication of the carrier state decreases surgical-site infections caused by MRSA. J Am Coll Surg 208:981–988

    PubMed  Google Scholar 

  264. 264.

    Harbarth S, Masuet-Aumatell C, Schrenzel J et al (2006) Evaluation of rapid screening and pre-emptive contact isolation for detecting and controlling methicillin-resistant Staphylococcus aureus in critical care: an interventional cohort study. Crit Care (London England) 10:R25

    PubMed  PubMed Central  Google Scholar 

  265. 265.

    Troche G, Joly LM, Guibert M et al (2005) Detection and treatment of antibiotic-resistant bacterial carriage in a surgical intensive care unit: a 6-year prospective survey. Infect Control Hosp Epidemiol 26:161–165

    PubMed  Google Scholar 

  266. 266.

    Gould IM, MacKenzie FM, MacLennan G et al (2007) Topical antimicrobials in combination with admission screening and barrier precautions to control endemic methicillin-resistant Staphylococcus aureus in an intensive care unit. Int J Antimicrob Agents 29:536–543

    CAS  PubMed  Google Scholar 

  267. 267.

    Clancy M, Graepler A, Wilson M et al (2006) Active screening in high-risk units is an effective and cost-avoidant method to reduce the rate of methicillin-resistant Staphylococcus aureus infection in the hospital. Infect Control Hosp Epidemiol 27:1009–1017

    PubMed  Google Scholar 

  268. 268.

    Thompson DS, Workman R, Strutt M (2009) Decline in the rates of methicillin-resistant Staphylococcus aureus acquisition and bacteraemia in a general intensive care unit between 1996 and 2008. J Hosp Infect 71:314–319

    CAS  PubMed  Google Scholar 

  269. 269.

    Rodriguez-Bano J, Garcia L, Ramirez E et al (2010) Long-term control of endemic hospital-wide methicillin-resistant Staphylococcus aureus (MRSA): the impact of targeted active surveillance for MRSA in patients and healthcare workers. Infect Control Hosp Epidemiol 31:786–795

    PubMed  Google Scholar 

  270. 270.

    Chaberny I, Schwab F, Ziesing S et al (2008) Impact of routine surgical ward and intensive care unit admission surveillance cultures on hospital-wide nosocomial methicillin-resistant Staphylococcus aureus infections in a university hospital: an interrupted time-series analysis. J Antimicrob Chemother 62:1422–1429

    CAS  PubMed  Google Scholar 

  271. 271.

    Tacconelli E, De Angelis G, de Waure C et al (2009) Rapid screening tests for methicillin-resistant Staphylococcus aureus at hospital admission: systematic review and meta-analysis. Lancet Infect Dis 9:546–554

    PubMed  Google Scholar 

  272. 272.

    Bootsma MC, Diekmann O, Bonten MJ (2006) Controlling methicillin-resistant Staphylococcus aureus: quantifying the effects of interventions and rapid diagnostic testing. Proc Natl Acad Sci USA 103:5620–5625

    CAS  PubMed  PubMed Central  Google Scholar 

  273. 273.

    Raboud J, Saskin R, Simor A et al (2005) Modeling transmission of methicillin-resistant Staphylococcus aureus among patients admitted to a hospital. Infect Control Hosp Epidemiol 26:607–615

    PubMed  Google Scholar 

  274. 274.

    Harbarth S, Fankhauser C, Schrenzel J et al (2008) Universal screening for methicillin-resistant Staphylococcus aureus at hospital admission and nosocomial infection in surgical patients. JAMA 299:1149–1157

    CAS  PubMed  Google Scholar 

  275. 275.

    Kurup A, Chlebicka N, Tan KY et al (2010) Active surveillance testing and decontamination strategies in intensive care units to reduce methicillin-resistant Staphylococcus aureus infections. Am J Infect Control 38:361–367

    PubMed  Google Scholar 

  276. 276.

    Leonhardt KK, Yakusheva O, Phelan D et al (2011) Clinical effectiveness and cost benefit of universal versus targeted methicillin-resistant Staphylococcus aureus screening upon admission in hospitals. Infect Control Hosp Epidemiol 32:797–803

    PubMed  Google Scholar 

  277. 277.

    Wang JT, Lauderdale TL, Lee WS et al (2010) Impact of active surveillance and contact isolation on transmission of methicillin-resistant Staphylococcus aureus in intensive care units in an area with high prevalence. J Formos Med Assoc 109:258–268

    PubMed  Google Scholar 

  278. 278.

    Warren DK, Guth RM, Coopersmith CM et al (2007) Impact of a methicillin-resistant Staphylococcus aureus active surveillance program on contact precaution utilization in a surgical intensive care unit. Crit Care Med 35:430–434

    PubMed  Google Scholar 

  279. 279.

    Huskins WC, Huckabee CM, O’Grady NP et al (2011) Intervention to reduce transmission of resistant bacteria in intensive care. N Engl J Med 364:1407–1418

    PubMed  PubMed Central  Google Scholar 

  280. 280.

    Cunningham R, Jenks P, Northwood J et al (2007) Effect on MRSA transmission of rapid PCR testing of patients admitted to critical care. J Hosp Infect 65:24–28

    CAS  PubMed  Google Scholar 

  281. 281.

    Noorani HZ, Adams E, Glick S et al (2013) Screening for methicillin-resistant Staphylococcus aureus (MRSA): future research needs: identification of future research needs from comparative effectiveness, Review No. 102. Agency for Healthcare Research and Quality, Rockville (MD)

  282. 282.

    Aldeyab MA, Kearney MP, Hughes CM et al (2009) Can the use of a rapid polymerase chain screening method decrease the incidence of nosocomial methicillin-resistant Staphylococcus aureus? J Hosp Infect 71:22–28

    CAS  PubMed  Google Scholar 

  283. 283.

    Camus C, Bellissant E, Legras A et al (2011) Randomized comparison of 2 protocols to prevent acquisition of methicillin-resistant Staphylococcus aureus: results of a 2-center study involving 500 patients. Infect Control Hosp Epidemiol 32:1064–1072

    PubMed  Google Scholar 

  284. 284.

    Jeyaratnam D, Whitty CJ, Phillips K et al (2008) Impact of rapid screening tests on acquisition of methicillin-resistant Staphylococcus aureus: cluster randomised crossover trial. BMJ 336:927–930

    PubMed  PubMed Central  Google Scholar 

  285. 285.

    Hardy K, Price C, Szczepura A et al (2010) Reduction in the rate of methicillin-resistant Staphylococcus aureus acquisition in surgical wards by rapid screening for colonization: a prospective, cross-over study. Clin Microbiol Infect 16:333–339

    PubMed  Google Scholar 

  286. 286.

    Kohlenberg ASF, Behnke M, Gastmeier P (2011) Screening and control of MRSA in 186 intensive care units: different situations and individual solutions. Crit Care Med 15:R285

    Google Scholar 

  287. 287.

    Vos MC, Behrendt MD, Melles DC et al (2009) 5 years of experience implementing a methicillin-resistant Staphylococcus aureus search and destroy policy at the largest university medical center in the Netherlands. Infect Control Hosp Epidemiol 30:977–984

    PubMed  Google Scholar 

  288. 288.

    Salgado CD, Farr BM (2006) What proportion of hospital patients colonized with methicillin-resistant Staphylococcus aureus are identified by clinical microbiological cultures? Infect Control Hosp Epidemiol 27:116–121

    PubMed  Google Scholar 

  289. 289.

    Tübbicke A, Hübner C, Hübner NO et al (2012) Cost comparison of MRSA screening and management – a decision tree analysis. BMC Health Serv Res 12:438

    PubMed  PubMed Central  Google Scholar 

  290. 290.

    Mertz D, Frei R, Jaussi B et al (2007) Throat swabs are necessary to reliably detect carriers of Staphylococcus aureus. Clin Infect Dis 45:475–477

    PubMed  Google Scholar 

  291. 291.

    Nilsson P, Ripa T (2006) Staphylococcus aureus throat colonization is more frequent than colonization in the anterior nares. J Clin Microbiol 44:3334–3339

    CAS  PubMed  PubMed Central  Google Scholar 

  292. 292.

    Mertz D, Frei R, Periat N et al (2009) Exclusive Staphylococcus aureus throat carriage: at-risk populations. Arch Intern Med 169:172–178

    PubMed  Google Scholar 

  293. 293.

    Harbarth S, Schrenzel J, Renzi G et al (2007) Is throat screening necessary to detect methicillin-resistant Staphylococcus aureus colonization in patients upon admission to an intensive care unit? J Clin Microbiol 45:1072–1073

    PubMed  PubMed Central  Google Scholar 

  294. 294.

    Marshall C, Spelman D (2007) Re: is throat screening necessary to detect methicillin-resistant Staphylococcus aureus colonization in patients upon admission to an intensive care unit? J Clin Microbiol 45:3855

    PubMed  PubMed Central  Google Scholar 

  295. 295.

    Heng Sim BL,McBryde, Street AC et al (2013) Multiple site surveillance cultures as a predictor of methicillin-resistant Staphylococcus aureus infections. Infect Control Hosp Epidemiol 34:818–824

    Google Scholar 

  296. 296.

    Bitterman Y, Laor A, Itzhaki S et al (2010) Characterization of the best anatomical sites in screening for methicillin-resistant Staphylococcus aureus colonization. Eur J Clin Microbiol Infect Dis 29:391–397

    CAS  PubMed  Google Scholar 

  297. 297.

    McKinnell JA, Huang SS, Eells SJ et al (2013) Quantifying the impact of extranasal testing of body sites for methicillin-resistant Staphylococcus aureus colonization at the time of hospital or intensive care unit admission. Infect Control Hosp Epidemiol 34:161–170

    PubMed  PubMed Central  Google Scholar 

  298. 298.

    Daeschlein G, Assadian O, Daxboeck F et al (2006) Multiplex PCR-ELISA for direct detection of MRSA in nasal swabs advantageous for rapid identification of non-MRSA carriers. Eur J Clin Microbiol Infect Dis 25:328–330

    CAS  PubMed  Google Scholar 

  299. 299.

    Holfelder M, Eigner U, Turnwald AM et al (2006) Direct detection of methicillin-resistant Staphylococcus aureus in clinical specimens by a nucleic acid-based hybridisation assay. Clin Microbiol Infect 12:1163–1167

    CAS  PubMed  Google Scholar 

  300. 300.

    Becker K, Berner R, Eckmann C et al (2013) Infektionen der Haut und der subkutanen Weichgewebe. Qualitätsstandards in der mikrobiologisch-infektiologischen Diagnostik. MIQ 06b. Elsevier, München

    Google Scholar 

  301. 301.

    Forster AJ, Oake N, Roth V et al (2013) Patient-level factors associated with methicillin-resistant Staphylococcus aureus carriage at hospital admission: a systematic review. Am J Infect Control 41:214–220

    PubMed  Google Scholar 

  302. 302.

    Köck R (2013) Zum Aufwand von MRSA-Screeninguntersuchungen in deutschen Krankenhäusern. Epidemiol Bull 5:41–44

    Google Scholar 

  303. 303.

    Chi CY, Wong WW, Fung CP et al (2004) Epidemiology of community-acquired Staphylococcus aureus bacteremia. J Microbiol Immunol Infect 37:16–23

    PubMed  Google Scholar 

  304. 304.

    Bode LG, Kluytmans JA, Wertheim HF et al (2010) Preventing surgical-site infections in nasal carriers of Staphylococcus aureus. N Engl J Med 362:9–17

    CAS  PubMed  Google Scholar 

  305. 305.

    Patel M, Weinheimer JD, Waites KB et al (2008) Active surveillance to determine the impact of methicillin-resistant Staphylococcus aureus colonization on patients in intensive care units of a veterans affairs medical denter. Infect Control Hosp Epidemiol 29:503–509

    PubMed  Google Scholar 

  306. 306.

    Schmid H, Romanos A, Schiffl H et al (2013) Persistent nasal methicillin-resistant Staphylococcus aureus carriage in hemodialysis outpatients: a predictor of worse outcome. BMC Nephrol 14:93

    PubMed  PubMed Central  Google Scholar 

  307. 307.

    Carnicer-Pont D, Bailey KA, Mason BW et al (2006) Risk factors for hospital-acquired methicillin-resistant Staphylococcus aureus bacteraemia: a case-control study. Epidemiol Infect 134:1167–1173

    CAS  PubMed  PubMed Central  Google Scholar 

  308. 308.

    Yoon YK, Kim JY, Park DW et al (2010) Predictors of persistent methicillin-resistant Staphylococcus aureus bacteraemia in patients treated with vancomycin. J Antimicrob Chemother 65:1015–1018

    CAS  PubMed  Google Scholar 

  309. 309.

    Fowler JVG, Justice A, Moore C et al (2005) Risk factors for hematogenous complications of intravascular catheter-associated Staphylococcus aureus bacteremia. Clin Infect Dis 40:695–703

    PubMed  Google Scholar 

  310. 310.

    Kato N, Tanaka J, Mori A et al (2003) The risk of persistent carriage of methicillin-resistant Staphylococcus aureus in hematopoietic stem cell transplantation. Ann Hematol 82:310–312

    CAS  PubMed  Google Scholar 

  311. 311.

    Nguyen MH, Kauffman CA, Goodman RP et al (1999) Nasal carriage of and infection with Staphylococcus aureus in HIV-infected patients. Ann Intern Med 130:221–225

    CAS  PubMed  Google Scholar 

  312. 312.

    Bessesen MT, Lopez K, Guerin K et al (2013) Comparison of control strategies for methicillin-resistant Staphylococcus aureus. Am J Infect Control 42:91

    Google Scholar 

  313. 313.

    Bracco D, Dubois MJ, Bouali R et al (2007) Single rooms may help to prevent nosocomial bloodstream infection and cross-transmission of methicillin-resistant Staphylococcus aureus in intensive care units. Intensive Care Med 33:836–840

    PubMed  Google Scholar 

  314. 314.

    Cheng VC, Tai JW, Chan WM et al (2010) Sequential introduction of single room isolation and hand hygiene campaign in the control of methicillin-resistant Staphylococcus aureus in intensive care unit. BMC Infect Dis 10:263

    PubMed  PubMed Central  Google Scholar 

  315. 315.

    Curran ET, Hamilton K, Monaghan A et al (2006) Use of a temporary cohort ward as part of an intervention to reduce the incidence of methicillin-resistant Staphylococcus aureus in a vascular surgery ward. J Hosp Infect 63:374–379

    CAS  PubMed  Google Scholar 

  316. 316.

    Fitzpatrick F, Murphy OM, Brady A et al (2000) A purpose built MRSA cohort unit. J Hosp Infect 46:271–279

    CAS  PubMed  Google Scholar 

  317. 317.

    Gagne D, Bedard G, Maziade PJ (2010) Systematic patients’ hand disinfection: impact on methicillin-resistant Staphylococcus aureus infection rates in a community hospital. J Hosp Infect 75:269–272

    CAS  PubMed  Google Scholar 

  318. 318.

    Gastmeier P, Schwab F, Geffers C et al (2004) To isolate or not to isolate? Analysis of data from the German nosocomial infection surveillance system regarding the placement of patients with methicillin-resistant Staphylococcus aureus in private rooms in intensive care units. Infect Control Hosp Epidemiol 25:109–113

    PubMed  Google Scholar 

  319. 319.

    Gilomen S, Ruef C, Held L et al. (2011) Successful control of methicillin-resistant Staphylococcus aureus outbreak at a university department of dermatology. J Eur Acad Dermatol Venereol 25:441–446

  320. 320.

    Gilroy SA, Miller Stahl B, Noonan C et al (2009) Reduction of hospital-acquired methicillin-resistant Staphylococcus aureus infection by cohorting patients in a dedicated unit. Infect Control Hosp Epidemiol 30:203–205

    PubMed  Google Scholar 

  321. 321.

    Gregory ML, Eichenwald EC, Puopolo KM (2009) Seven-year experience with a surveillance program to reduce methicillin-resistant Staphylococcus aureus colonization in a neonatal intensive care unit. Pediatrics 123:e790–e796

    PubMed  Google Scholar 

  322. 322.

    Jain R, Kralovic SM, Evans ME et al (2011) Veterans affairs initiative to prevent methicillin-resistant Staphylococcus aureus infections. N Engl J Med 364:1419–1430

    CAS  PubMed  Google Scholar 

  323. 323.

    Marshall C, Richards M, McBryde E (2013) Do active surveillance and contact precautions reduce MRSA acquisition? A prospective interrupted time series. PloS One 8:e58112

    CAS  PubMed  PubMed Central  Google Scholar 

  324. 324.

    Mastoraki A, Kriaras I, Douka E et al (2008) Methicillin-resistant Staphylococcus aureus preventing strategy in cardiac surgery. Interact Cardiovasc Thorac Surg 7:452–456

    PubMed  Google Scholar 

  325. 325.

    Safdar N, Marx J, Meyer NA et al (2006) Effectiveness of preemptive barrier precautions in controlling nosocomial colonization and infection by methicillin-resistant Staphylococcus aureus in a burn unit. Am J Infect Control 34:476–483

    PubMed  Google Scholar 

  326. 326.

    Teltsch DY, Hanley J, Loo V et al (2011) Infection acquisition following intensive care unit room privatization. Arch Intern Med 171:32–38

    PubMed  Google Scholar 

  327. 327.

    Trautmann M, Pollitt A, Loh U et al (2007) Implementation of an intensified infection control program to reduce MRSA transmissions in a German tertiary care hospital. Am J Infect Control 35:643–649

    PubMed  Google Scholar 

  328. 328.

    Landelle C, Pagani L, Harbarth S (2013) Is patient isolation the single most important measure to prevent the spread of multidrug-resistant pathogens? Virulence 4:163–171

    PubMed  PubMed Central  Google Scholar 

  329. 329.

    Lee AS, Cooper BS, Malhotra-Kumar S et al (2013) Comparison of strategies to reduce methicillin-resistant Staphylococcus aureus rates in surgical patients: a controlled multicentre intervention trial. BMJ Open 3:e003126

    PubMed  PubMed Central  Google Scholar 

  330. 330.

    Fazal BA, Telzak EE, Blum S et al (1996) Trends in the prevalence of methicillin-resistant Staphylococcus aureus associated with discontinuation of an isolation policy. Infect Control Hosp Epidemiol 17:372–374

    CAS  PubMed  Google Scholar 

  331. 331.

    Lecornet E, Robert J, Jacqueminet S et al (2007) Preemptive isolation to prevent methicillin-resistant Staphylococcus aureus cross-transmission in diabetic foot. Diabetes Care 30:2341–2342

    PubMed  Google Scholar 

  332. 332.

    Kalenic S, Pal MP, Palcevski VV et al (2010) Guidelines for prevention, control and treatment of infections caused by methicillin-resistant Staphylococcus aureus (MRSA): changes and updates of chapter 7.0: treatment of patients with MRSA infection. Lijec Vjesn 132:340–344

    PubMed  Google Scholar 

  333. 333.

    Burke JP (2003) Infection control – a problem for patient safety. N Engl J Med 348:651–656

    PubMed  Google Scholar 

  334. 334.

    Stelfox HT (2003) Safety of patients isolated for infection control. JAMA 290:1899–1905

    CAS  PubMed  Google Scholar 

  335. 335.

    Morgan DJ, Diekema DJ, Sepkowitz K et al (2009) Adverse outcomes associated with contact precautions: a review of the literature. Am J Infect Control 37:85–93

    PubMed  PubMed Central  Google Scholar 

  336. 336.

    Masse V, Valiquette L, Boukhoudmi S et al (2013) Impact of methicillin-resistant Staphylococcus aureus contact isolation units on medical care. PloS One 8:e57057

    CAS  PubMed  PubMed Central  Google Scholar 

  337. 337.

    Hartmann C (2006) How do patients experience isolation due to an infection or colonisation with MRSA? Pflege Z 59(10):suppl 2–8

    PubMed  Google Scholar 

  338. 338.

    Gasink LB, Singer K, Fishman NO et al (2008) Contact isolation for infection control in hospitalized patients: is patient satisfaction affected? Infect Control Hosp Epidemiol 29:275–278

    PubMed  Google Scholar 

  339. 339.

    Safdar N, Maki DG (2004) Quality of care and satisfaction among patients isolated for infection control. JAMA 291:420–422

    PubMed  Google Scholar 

  340. 340.

    Cohen E, Austin J, Weinstein M et al (2008) Care of children isolated for infection control: a prospective observational cohort study. Pediatrics 122:e411–e415

    PubMed  Google Scholar 

  341. 341.

    Kabbani D, Weir SK, Berg G et al (2013) Cohorting based on nasal methicillin-resistant Staphylococcus aureus status: an opportunity to share more than a room. Am J Infect Control 41:401–404

    PubMed  Google Scholar 

  342. 342.

    Islam J, Cheek E, Navani V et al (2013) Influence of cohorting patients with Clostridium difficile infection on risk of symptomatic recurrence. J Hosp Infect 85:17–21

    CAS  PubMed  Google Scholar 

  343. 343.

    Pittet D, Dharan S, Touveneau S et al (1999) Bacterial contamination of the hands of hospital staff during routine patient care. Arch Intern Med 159:821–826

    CAS  PubMed  Google Scholar 

  344. 344.

    Lucet JC, Rigaud MP, Mentre F et al (2002) Hand contamination before and after different hand hygiene techniques: a randomized clinical trial. J Hosp Infect 50:276–280

    PubMed  Google Scholar 

  345. 345.

    Boyce JM, Potter-Bynoe G, Chenevert C et al (1997) Environmental contamination due to methicillin-resistant Staphylococcus aureus: possible infection control implications. Infect Control Hosp Epidemiol 18:622–627

    CAS  PubMed  Google Scholar 

  346. 346.

    Zachary KC, Bayne PS, Morrison VJ et al (2001) Contamination of gowns, gloves, and stethoscopes with vancomycin-resistant enterococci. Infect Control Hosp Epidemiol 22:560–564

    CAS  PubMed  Google Scholar 

  347. 347.

    Sroka S, Gastmeier P, Meyer E (2010) Impact of alcohol hand-rub use on methicillin-resistant Staphylococcus aureus: an analysis of the literature. J Hosp Infect 74:204–211

    CAS  PubMed  Google Scholar 

  348. 348.

    Mertz D, Dafoe N, Walter SD et al (2010) Effect of a multifaceted intervention on adherence to hand hygiene among healthcare workers: a cluster-randomized trial. Infect Control Hosp Epidemiol 31:1170–1176

    PubMed  Google Scholar 

  349. 349.

    McLaws ML, Pantle AC, Fitzpatrick KR et al (2009) More than hand hygiene is needed to affect methicillin-resistant Staphylococcus aureus clinical indicator rates: clean hands save lives, part IV. Med J Aust 191:26–31

    Google Scholar 

  350. 350.

    Eveillard M, Eb F, Tramier B et al (2001) Evaluation of the contribution of isolation precautions in prevention and control of multi-resistant bacteria in a teaching hospital. J Hosp Infect 47:116–124

    CAS  PubMed  Google Scholar 

  351. 351.

    Jarlier V, Trystram D, Brun-Buisson C et al (2010) Curbing methicillin-resistant Staphylococcus aureus in 38 French hospitals through a 15-year institutional control program. Arch Intern Med 170:552–559

    PubMed  Google Scholar 

  352. 352.

    Huang SS, Platt R (2003) Risk of methicillin-resistant Staphylococcus aureus infection after previous infection or colonization. Clin Infect Dis 36:281–285

    PubMed  Google Scholar 

  353. 353.

    Robicsek A, Beaumont JL, Thomson RB Jr et al (2009) Topical therapy for methicillin-resistant Staphylococcus aureus colonization: impact on infection risk. Infect Control Hosp Epidemiol 30:623–632

    PubMed  Google Scholar 

  354. 354.

    Miller LG, Tan J, Eells SJ et al (2012) Prospective investigation of nasal mupirocin, hexachlorophene body wash, and systemic antibiotics for prevention of recurrent community-associated methicillin-resistant Staphylococcus aureus infections. Antimicrob Agents Chemother 56:1084–1086

    CAS  PubMed  PubMed Central  Google Scholar 

  355. 355.

    Wilcox MH, Hall J, Pike H et al (2003) Use of perioperative mupirocin to prevent methicillin-resistant Staphylococcus aureus (MRSA) orthopaedic surgical site infections. J Hosp Infect 54:196–201

    CAS  PubMed  Google Scholar 

  356. 356.

    Horiuchi A, Nakayama Y, Kajiyama M et al (2006) Nasopharyngeal decolonization of methicillin-resistant Staphylococcus aureus can reduce PEG peristomal wound infection. Am J Gastroenterol 101:274–277

    PubMed  Google Scholar 

  357. 357.

    van Rijen MB, Wenzel R et al. (2008) Mupirocin ointment for preventing Staphylococcus aureus infections in nasal carriers. Cochrane Database Syst Rev CD006216

  358. 358.

    van Rijen MM,B, Wenzel RP et al (2008) Intranasal mupirocin for reduction of Staphylococcus aureus infections in surgical patients with nasal carriage: a systematic review. J Antimicrob Chemother 61:254–261

    PubMed  Google Scholar 

  359. 359.

    Derde LP, Dautzenberg MJ, Bonten MJ (2012) Chlorhexidine body washing to control antimicrobial-resistant bacteria in intensive care units: a systematic review. Intensive Care Med 38:931–939

    CAS  PubMed  PubMed Central  Google Scholar 

  360. 360.

    Ridenour G, Lampen R, Federspiel J et al (2007) Selective use of intranasal mupirocin and chlorhexidine bathing and the incidence of methicillin-resistant Staphylococcus aureus colonization and infection among intensive care unit patients. Infect Control Hosp Epidemiol 28:1155–1161

    PubMed  Google Scholar 

  361. 361.

    Sandri AM, Dalarosa MG, Ruschel de Alcantara L et al (2006) Reduction in incidence of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infection in an intensive care unit: role of treatment with mupirocin ointment and chlorhexidine baths for nasal carriers of MRSA. Infect Control Hosp Epidemiol 27:185–187

    PubMed  Google Scholar 

  362. 362.

    Vernon MO, Hayden MK, Trick WE et al (2006) Chlorhexidine gluconate to cleanse patients in a medical intensive care unit: the effectiveness of source control to reduce the bioburden of vancomycin-resistant enterococci. Arch Intern Med 166:306–312

    CAS  PubMed  Google Scholar 

  363. 363.

    Ammerlaan H, Kluytmans J, Wertheim H et al (2009) Eradication of methicillin-resistant Staphylococcus aureus carriage: a systematic review. Clin Infect Dis 48:922–930

    CAS  PubMed  Google Scholar 

  364. 364.

    Casewell MW, Hill RL (1986) Elimination of nasal carriage of Staphylococcus aureus with mupirocin (‘pseudomonic acid’) – a controlled trial. J Antimicrob Chemother 17:365–372

    CAS  PubMed  Google Scholar 

  365. 365.

    Huang SS, Septimus E, Kleinman K et al (2013) Targeted versus universal decolonization to prevent ICU infection. N Engl J Med 368:2255–2265

    CAS  PubMed  Google Scholar 

  366. 366.

    Climo M, Yokoe DS, Wareen DK, Perl TM, Bolon M (2013) Effect of daily chlorhexidine bathing on hospital-acquired infection. N Engl J Med 368:533–542

    CAS  PubMed  Google Scholar 

  367. 367.

    Climo MW, Sepkowitz KA, Zuccotti G, Fraser VJ (2009) The effect of daily bathing with chlorhexidine on the acquisition of MRSA, vancomycin-resistant Enterococcus, and healthcare-associated bloodstream infections: results of a quasi-experimental multicenter trial. Crit Care Med 37:1858–1865

    CAS  PubMed  Google Scholar 

  368. 368.

    Derde LP, Cooper BS, Goossens H (2014) Interventions to reduce colonisation and transmission of antimicrobial-resistant bacteria in intensive care units: an interrupted time series study and cluster randomised trial. Lancet Infect Dis 14:31–39

    PubMed  PubMed Central  Google Scholar 

  369. 369.

    Becker K, Werner G, Friedrich A (2013) MRSA-Screening: Für und wider aktive Surveillance. Dtsch Ärztebl 110:1789–1791

    Google Scholar 

  370. 370.

    Harbarth S, Dharan S, Liassine N et al (1999) Randomized, placebo-controlled, double-blind trial to evaluate the efficacy of mupirocin for eradicating carriage of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 43:1412–1416

    CAS  PubMed  PubMed Central  Google Scholar 

  371. 371.

    Simor AE, Phillips E, McGeer A et al (2007) Randomized controlled trial of chlorhexidine gluconate for washing, intranasal mupirocin, and rifampin and doxycycline versus no treatment for the eradication of methicillin-resistant Staphylococcus aureus colonization. Clin Infect Dis 44:178–185

    CAS  PubMed  Google Scholar 

  372. 372.

    Wendt C, Schinke S, Württemberger M et al (2007) Value of whole-body washing with chlorhexidine for the eradication of methicillin-resistant Staphylococcus aureus: a randomized, placebo-controlled, double-blind clinical trial. Infect Control Hosp Epidemiol 28:1036–1043

    CAS  PubMed  Google Scholar 

  373. 373.

    Vasquez JE, Walker ES, Franzus BW et al (2000) The epidemiology of mupirocin resistance among methicillin-resistant Staphylococcus aureus at a Veterans’ Affairs hospital. Infect Control Hosp Epidemiol 21:459–464

    CAS  PubMed  Google Scholar 

  374. 374.

    Harbarth S, Liassine N, Dharan S et al (2000) Risk factors for persistent carriage of methicillin-resistant Staphylococcus aureus. Clin Infect Dis 31:1380–1385

    CAS  PubMed  Google Scholar 

  375. 375.

    Leigh DA, Joy G (1993) Treatment of familial staphylococcal infection – comparison of mupirocin nasal ointment and chlorhexidine/neomycin (Naseptin) cream in eradication of nasal carriage. J Antimicrob Chemother 31:909–917

    CAS  PubMed  Google Scholar 

  376. 376.

    McAnally TP, Lewis MR, Brown DR (1984) Effect of rifampin and bacitracin on nasal carriers of Staphylococcus aureus. Antimicrob Agents Chemother 25:422–426

    CAS  PubMed  PubMed Central  Google Scholar 

  377. 377.

    Parras F, Guerrero MC, Bouza E et al (1995) Comparative study of mupirocin and oral co-trimoxazole plus topical fusidic acid in eradication of nasal carriage of methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 39:175–179

    CAS  PubMed  PubMed Central  Google Scholar 

  378. 378.

    Soto NE, Vaghjimal A, Stahl-Avicolli A et al (1999) Bacitracin versus mupirocin for Staphylococcus aureus nasal colonization. Infect Control Hosp Epidemiol 20:351–353

    CAS  PubMed  Google Scholar 

  379. 379.

    Pitten FA, Werner HP, Kramer A (2003) A standardized test to assess the impact of different organic challenges on the antimicrobial activity of antiseptics. J Hosp Infect 55:108–115

    PubMed  Google Scholar 

  380. 380.

    Hill RL, Casewell MW (2000) The in-vitro activity of povidone-iodinecream against Staphylococcus aureus and its bioavailability in nasal secretions. J Hosp Infect 45:198–205

    CAS  PubMed  Google Scholar 

  381. 381.

    Segers P, Speekenbrink RG, Ubbink DT et al (2006) Prevention of nosocomial infection in cardiac surgery by decontamination of the nasopharynx and oropharynx with chlorhexidine gluconate: a randomized controlled trial. JAMA 296:2460–2466

    CAS  PubMed  Google Scholar 

  382. 382.

    Caelli M, Porteous J, Carson CF et al (2000) Tea tree oil as an alternative topical decolonization agent for methicillin-resistant Staphylococcus aureus. J Hosp Infect 46:236–237

    CAS  PubMed  Google Scholar 

  383. 383.

    Dryden MS, Dailly S, Crouch M (2004) A randomized, controlled trial of tea tree topical preparations versus a standard topical regimen for the clearance of MRSA colonization. J Hosp Infect 56:283–286

    CAS  PubMed  Google Scholar 

  384. 384.

    Ansorg RA, Azem T, Fabry WH et al (2002) Influence of mucin on the activity of the antiseptic Lavasept against Staphylococcus aureus. Chemotherapy 48:129–133

    CAS  PubMed  Google Scholar 

  385. 385.

    Hill RL (2002) The bioavailability of mupirocin in nasal secretions in vitro. J Clin Pathol 55:233–235

    CAS  PubMed  PubMed Central  Google Scholar 

  386. 386.

    Kramer A, Hoppe H, Krull B et al. (1998) Antiseptic efficacy and acceptance of octenisept computed with common antiseptic mouthwashes. Zentralbl Hyg Umweltmed 200:443–456

  387. 387.

    Pitten FA, Kiefer T, Buth C et al (2003) Do cancer patients with chemotherapy-induced leukopenia benefit from an antiseptic chlorhexidine-based oral rinse? A double-blind, block-randomized, controlled study. J Hosp Infect 53:283–291

    PubMed  Google Scholar 

  388. 388.

    Tomas I, Alvarez M, Limeres J et al (2007) Effect of a chlorhexidine mouthwash on the risk of postextraction bacteremia. Infect Control Hosp Epidemiol 28:577–582

    CAS  PubMed  Google Scholar 

  389. 389.

    Clavero J, Baca P, Junco P et al (2003) Effects of 0.2 % chlorhexidine spray applied once or twice daily on plaque accumulation and gingival inflammation in a geriatric population. J Clin Periodontol 30:773–777

    CAS  PubMed  Google Scholar 

  390. 390.

    van Steenberghe D (1997) Breath malodor. Curr Opin Periodontol 4:137–143

    PubMed  Google Scholar 

  391. 391.

    Kola A, Gastmeier P (2007) Efficacy of oral chlorhexidine in preventing lower respiratory tract infections. Meta-analysis of randomized controlled trials. J Hosp Infect 66:207–216

    CAS  PubMed  Google Scholar 

  392. 392.

    Rohr U, Mueller C, Wilhelm M et al (2003) Methicillin-resistant Staphylococcus aureus whole-body decolonization among hospitalized patients with variable site colonization by using mupirocin in combination with octenidine dihydrochloride. J Hosp Infect 54:305–309

    CAS  PubMed  Google Scholar 

  393. 393.

    Sloot N, Siebert J, Hoffler U (1999) Eradication of MRSA from carriers by means of whole-body washing with an antiseptic in combination with mupirocin nasal ointment. Zentralbl Hyg Umweltmed 202:513–523

  394. 394.

    Zafar AB, Butler RC, Reese DJ et al (1995) Use of 0.3 % triclosan (Bacti-Stat) to eradicate an outbreak of methicillin-resistant Staphylococcus aureus in a neonatal nursery. Am J Infect Control 23:200–208

    CAS  PubMed  Google Scholar 

  395. 395.

    Nguyen DM, Mascola L, Brancoft E (2005) Recurring methicillin-resistant Staphylococcus aureus infections in a football team. Emerg Infect Dis 11:526–532

    PubMed  PubMed Central  Google Scholar 

  396. 396.

    Wilcox MH, Hall J, Gill AB et al (2004) Effectiveness of topical chlorhexidine powder as an alternative to hexachlorophane for the control of Staphylococcus aureus in neonates. J Hosp Infect 56:156–159

    CAS  PubMed  Google Scholar 

  397. 397.

    Kampf G, Kramer A (2004) Eradication of methicillin-resistant Staphylococcus aureus with an antiseptic soap and nasal mupirocin among colonized patients – an open uncontrolled clinical trial. Ann Clin Microbiol Antimicrob 3:9

    PubMed  PubMed Central  Google Scholar 

  398. 398.

    Hamson C, Bignardi GE (2010) MRSA decolonization with Prontoderm compared with chlorhexidine and mupirocin. J Hosp Infect 75:142–143

    CAS  PubMed  Google Scholar 

  399. 399.

    Jappe U, Schnuch A, Uter W (2003) Frequency of sensitization to antimicrobials in patients with atopic eczema compared with nonatopic individuals: analysis of multicentre surveillance data, 1995–1999. Br J Dermatol 149:87–93

    CAS  PubMed  Google Scholar 

  400. 400.

    Karki S, Cheng AC (2012) Impact of non-rinse skin cleansing with chlorhexidine gluconate on prevention of healthcare-associated infections and colonization with multi-resistant organisms: a systematic review. J Hosp Infect 82:71–84

    CAS  PubMed  Google Scholar 

  401. 401.

    Loeb MB, Main C, Eady A et al. (2003) Antimicrobial drugs for treating methicillin-resistant Staphylococcus aureus colonization. Cochrane Database Syst Rev (4):CD003340

  402. 402.

    Simon A, Exner M, Kramer A et al. (2009) Implementing the MRSA recommendations made by the Commission for Hospital Hygiene and Infection Prevention (KRINKO) of 1999 – current considerations by the DGKH Management Board GMS Krankenhaushyg Interdiszip. 4:Doc2

  403. 403.

    Berthelot P, Grattard F, Fascia P et al (2003) Implication of a healthcare worker with chronic skin disease in the transmission of an epidemic strain of methicillin-resistant Staphylococcus aureus in a pediatric intensive care unit. Infect Control Hosp Epidemiol 24:299–300

    PubMed  Google Scholar 

  404. 404.

    Bertin ML, Vinski J, Schmitt S et al (2006) Outbreak of methicillin-resistant Staphylococcus aureus colonization and infection in a neonatal intensive care unit epidemiologically linked to a healthcare worker with chronic otitis. Infect Control Hosp Epidemiol 27:581–585

    PubMed  Google Scholar 

  405. 405.

    Faibis F, Laporte C, Fiacre A et al (2005) An outbreak of methicillin-resistant Staphylococcus aureus surgical-site infections initiated by a healthcare worker with chronic sinusitis. Infect Control Hosp Epidemiol 26:213–215

    PubMed  Google Scholar 

  406. 406.

    Kluytmans J, Harbarth S (2009) Methicillin-resistant Staphylococcus aureus decolonization: "yes, we can," but will it help? Infect Control Hosp Epidemiol 30:633–635

    PubMed  Google Scholar 

  407. 407.

    Kramer A, Daeschlein G, Kammerlander G et al (2004) Konsensusempfehlung zur Auswahl von Wirkstoffen für die Wundantiseptik. Z Wundheilung 3:110–120

  408. 408.

    Gerber V (2008) Zur Versorgung von Patienten mit chronischen Wunden im Rahmen von Versorgungsnetzwerken. Epidemiol Bull 41:351–353

  409. 409.

    Dietze B, Rath A, Wendt C et al (2001) Survival of MRSA on sterile goods packaging. J Hosp Infect 49:255–261

    CAS  PubMed  Google Scholar 

  410. 410.

    Allen KD, Anson JJ, Parsons LA et al (1997) Staff carriage of methicillin-resistant Staphylococcus aureus (EMRSA 15) and the home environment: a case report. J Hosp Infect 35:307–311

    CAS  PubMed  Google Scholar 

  411. 411.

    Kniehl E, Becker A, Forster DH (2005) Bed, bath and beyond: pitfalls in prompt eradication of methicillin-resistant Staphylococcus aureus carrier status in healthcare workers. J Hosp Infect 59:180–187

    CAS  PubMed  Google Scholar 

  412. 412.

    Forward KR (2010) The value of multiple surveillance cultures for methicillin-resistant Staphylococcus aureus. Am J Infect Control 38:596–599

    PubMed  Google Scholar 

  413. 413.

    Senn L, Basset P, Nahimana I et al (2012) Which anatomical sites should be sampled for screening of methicillin-resistant Staphylococcus aureus carriage by culture or by rapid PCR test? Clin Microbiol Infect 18:E31–E33

    CAS  PubMed  Google Scholar 

  414. 414.

    Eckmanns T, Geffers C, Weist K et al (2004) One hour versus 24 h sampling intervals for the screening of patients with methicillin-resistant Staphylococcus aureus (MRSA). J Hosp Infect 57:93–94

    CAS  PubMed  Google Scholar 

  415. 415.

    Darby JM, Linden P, Pasculle W et al (1997) Utilization and diagnostic yield of blood cultures in a surgical intensive care unit. Crit Care Med 25:989–994

    CAS  PubMed  Google Scholar 

  416. 416.

    Hoen B, Selton-Suty C, Lacassin F et al (1995) Infective endocarditis in patients with negative blood cultures: analysis of 88 cases from a one-year nationwide survey in France. Clin Infect Dis 20:501–506

    CAS  PubMed  Google Scholar 

  417. 417.

    Shafazand S, Weinacker AB (2002) Blood cultures in the critical care unit: improving utilization and yield. Chest 122:1727–1736

    PubMed  Google Scholar 

  418. 418.

    Robert Koch-Institut, Informationen zu regionalen MRE-Netzwerken. http://www.rki.de/DE/Content/Infekt/Krankenhaushygiene/Netzwerke/Netzwerke_node.html. Zugegriffen: April 2014

  419. 419.

    van Cleef BA, Kluytmans JA, van Benthem BH et al (2012) Cross border comparison of MRSA bacteraemia between The Netherlands and North Rhine-Westphalia (Germany): a cross-sectional study. PloS One 7:e42787

    CAS  PubMed  PubMed Central  Google Scholar 

  420. 420.

    Jurke A, Köck R, Becker K et al (2013) Reduction of the nosocomial methicillin-resistant Staphylococcus aureus incidence density by a region-wide search and follow-strategy in forty German hospitals of the EUREGIO, 2009 to 2011. Euro Surveillance 18:pii=20579

  421. 421.

    Nassauer A (2008) Kontrolle der Weiterverbreitung von MRSA – Personal im Gesundheitsdienst als Carrier. Epidemiol Bull 36:303–311

    Google Scholar 

  422. 422.

    von Baum HD, Föll M et al (2008) Consensus-Empfehlung Baden-Württemberg: Umgang mit MRSA-positivem Personal. Hyg Med 33:25–29

    Google Scholar 

  423. 423.

    Beigi RH (2011) Clinical implications of methicillin-resistant Staphylococcus aureus in pregnancy. Curr Opin Obstet Gynecol 23:82–86

    PubMed  Google Scholar 

  424. 424.

    Volk L, Thomson T, Chhangani P et al (2011) Methicillin-resistant Staphylococcus aureus nasal colonization among women admitted to labor and delivery and their newborn infants. Infect Control Hosp Epidemiol 32:1045–1046

    PubMed  Google Scholar 

  425. 425.

    Andrews JI, Fleener DK, Messer SA et al (2009) Screening for Staphylococcus aureus carriage in pregnancy: usefulness of novel sampling and culture strategies. Am J Obstet Gynecol 201(396):e391–e395

    Google Scholar 

  426. 426.

    Melendez J, Claxton A, Erskine K (2012) MRSA bacteraemia after caesarean section wound infection: when screening is missed and things go wrong. Arch Gynecol Obstet 285:663–665

    PubMed  Google Scholar 

  427. 427.

    Acton DS, Plat-Sinnige MJ, van Wamel W et al (2009) Intestinal carriage of Staphylococcus aureus: how does its frequency compare with that of nasal carriage and what is its clinical impact? Eur J Clin Microbiol Infect Dis 28:115–127

    CAS  PubMed  Google Scholar 

  428. 428.

    Crawford T, Rodvold KA, Solomkin JS (2012) Vancomycin for surgical prophylaxis? Clin Infect Dis 54:1474–1479

    PubMed  Google Scholar 

  429. 429.

    Liu C, Bayer A, Cosgrove SE et al (2011) Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children: executive summary. Clin Infect Dis 52:285–292

    PubMed  Google Scholar 

  430. 430.

    American College of Obstetricians and Gynecologists (2011) ACOG Practice Bulletin No. 120: Use of prophylactic antibiotics in labor and delivery. Obstet Gynecol 117:1472–1483

    Google Scholar 

  431. 431.

    Gray JW, Suviste J (2013) Three years’ experience of screening for methicillin-resistant Staphylococcus aureus in obstetrics. J Hosp Infect 83:61–63

    CAS  PubMed  Google Scholar 

  432. 432.

    Bergen P (2012) Informationen zu MRSA und weiteren multiresistenten Erregern für Rehabilitations-Einrichtungen – Eine Empfehlung der MRSA-Netzwerke Niedersachsen. Hyg Med 37:228–237

    Google Scholar 

  433. 433.

    Landesarbeitsgemeinschaft multiresistente Erreger (LARE). http://www.lgl.bayern.de/gesundheit/hygiene/lare/. Zugegriffen: April 2014

  434. 434.

    Fach-Intranet für Mitarbeiter im Öffentlichen Gesundheitsdienst auf Bundes-, Landes- und kommunaler Ebene. www.uminfo.de. Zugegriffen: April 2014

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Ruscher, C. Empfehlungen zur Prävention und Kontrolle von Methicillin-resistenten Staphylococcus aureus-Stämmen (MRSA) in medizinischen und pflegerischen Einrichtungen. Bundesgesundheitsbl. 57, 695–732 (2014). https://doi.org/10.1007/s00103-014-1980-x

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