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Die DONALD Kohorte

Ein aktueller Überblick zu 25 Jahren Forschung im Rahmen der Dortmund Nutritional and Anthropometric Longitudinally Designed Study

The DONALD cohort

An updated overview on 25 years of research based on the DOrtmund Nutritional and Anthropometric Longitudinally Designed study

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Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz Aims and scope

Zusammenfassung

Die DONALD Studie wird seit 1985 in Dortmund durchgeführt, um die komplexen Wechselwirkungen zwischen Ernährung, Stoffwechsel, Entwicklung und Wachstum bei gesunden Kindern zu analysieren. In die offene Kohorte werden jährlich etwa 40 Säuglinge neu eingeschlossen. Das engmaschige Studienprotokoll vom Säuglings- bis ins junge Erwachsenenalter umfasst anthropometrische Messungen, Drei-Tage-Wiege-Ernährungsprotokoll, 24-Stunden-Urinsammlung (ab dem dritten bis vierten Lebensjahr) und ärztliche Untersuchungen. Seit 2005 wird zu Nachuntersuchungen im Erwachsenenalter eingeladen (inklusive Nüchternblutprobe). Bis 2010 wurden etwa 1400 Probanden rekrutiert. Auswertungen aus den letzten Jahren zeigten unter anderem (i) die Bedeutung frühkindlicher Faktoren für die Entwicklung der Körperzusammensetzung und den Eintritt in die Pubertät sowie (ii) die Relevanz des präpubertären Hormonstatus für den Zeitpunkt des Pubertätsbeginns. Ferner wurden (iii) Alters- und Zeittrends im Jodstatus und in modernen Ernährungsgewohnheiten beschrieben, ebenso wie (iv) mögliche Furan- oder Benzol-Expositionen durch kommerzielle Beikost. Zukünftige Analysen sollen insbesondere die Relevanz von Ernährung, Wachstumsmustern und Hormonstatus in möglichen „kritischen Phasen“ während der Kindheit für die Gesundheit im Erwachsenenalter beleuchten.

Abstract

The DONALD study has been conducted in Dortmund, Germany since 1985 to examine the complex relations between nutritional intake, metabolism and growth from infancy to adulthood. Every year, approximately 40 infants are newly recruited into the open cohort study. Examinations conducted at ages 3, 6, 9, 12, 18, 24 months and then annually until young adulthood, comprise anthropometry, a 3 day weighed dietary record, a 24 h urine sample (from age 3–4 years onwards), medical examinations and parental interviews. Since 2005, participants are invited for follow-up visits during adulthood (including fasting blood samples). Approximately 1,400 children have been recruited into the study up to 2010. Recent findings revealed e.g. (i) the relevance of early life factors for subsequent development of body composition and puberty timing, (ii) the relation between pubertal hormonal status and puberty onset, (iii) age and time trends in iodine status and modern dietary habits and (iv) potential furan and benzol exposition by commercial weaning foods. Future analyses will provide insight into the extent to which health in young adulthood is receptive to diet, anthropometric pattern and hormonal status in distinct potentially critical periods during childhood.

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Authors and Affiliations

  1. DONALD Studie, Institut für Ernährungs- und Lebensmittelwissenschaften, Universität Bonn, Heinstück 11, 44225, Dortmund, Deutschland

    A.E. Buyken, U. Alexy & T. Remer

  2. Forschungsinstitut für Kinderernährung, Dortmund, Deutschland

    M. Kersting

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  1. A.E. Buyken
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  2. U. Alexy
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  3. M. Kersting
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  4. T. Remer
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Correspondence to A.E. Buyken.

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Buyken, A., Alexy, U., Kersting, M. et al. Die DONALD Kohorte. Bundesgesundheitsbl. 55, 875–884 (2012). https://doi.org/10.1007/s00103-012-1503-6

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