Zusammenfassung
Der vorliegende Beitrag stellt die derzeitigen diagnostischen Methoden und multimodalen, interdisziplinären Strategien in der Früherkennung und Therapie oraler Plattenepithelkarzinome dar.
Abstract
This article offers a short review of risk factors, oral precancerous conditions, and oral precancerous lesions which may cause oral squamous carcinoma. Current diagnostic methods and multidisciplinary strategies for the early detection and appropriate therapy of oral squamous carcinomas are discussed. Close cooperation of oral and maxillofacial surgeons, head and neck surgeons, radiotherapists, and oncologists is essential for the effective therapy of oral squamous carcinomas.
Literatur
Kowalski LP, Carvalho AL (2001) Influence of time delay and clinical upstaging in the prognosis of head and neck cancer. Oral Oncol 37:94–98
Schleier P, Zenk W, Dietel W (2002) Fluoreszenz beim Mundhöhlenkarzinom. HNO-Nachrichten 5:22–24
Gale N, Pilch BZ, Sidransky D et al (2005) Epithelial precursor lesions. In: Barnes L, Eveson JW, Reichart PA, Sidransky D (Hrsg) World Health Organization classification of tumours. Pathology and genetics: head and neck tumours. IARC Press, Lyon, S 177–179
Johnson N, Franceschi S, Ferlay J et al (2005) Squamous cell carcinoma. In: Barnes L, Eveson JW, Reichart PA, Sidransky D (Hrsg) World Health Organization classification of tumours. Pathology and genetics: head and neck tumours. IARC Press, Lyon, S 168–175
El Naggar AK, Reichart PA (2005) Proliferative verrucous leukoplakia and precancerous conditions. In: Barnes L, Eveson JW, Reichart PA, Sidransky D (Hrsg) World Health Organization classification of tumours. Pathology and genetics: head and neck tumours. IARC Press, Lyon, S 180–181
Scully C, Bagan J (2009) Oral squamous cell carcinoma overview. Oral Oncol 45:301–308
Cardesa A, Gale N, Nadal A, Zidar N (2005) Squamous cell carcinoma. In: Barnes L, Eveson JW, Reichart P, Sidransky D (Hrsg) World Health Organization classification of tumours. Pathology and genetics of head and neck tumours. IARC Press, Lyon, S 140–143
Van der Waal I, Reichart PA (2008) Oral proliferative verrucous leukoplakia revisited. Oral Oncol 44:719–721
Wrangle JM, Khuri FR (2007) Chemoprevention of squamous cell carcinoma of the head and neck. Curr Opin Oncol 19:180–187
Holmstrup P, Vedtofte P, Reibel J, Stoltze K (2006) Longterm treatment outcome of oral premalignant lesions. Oral Oncol 42:461–474
Neville BW, Day TA (2002) Oral cancer and precancerous lesions. CA Cancer J Clin 52:195–215
Batsakis JG, Suarez P, El-Naggar AK (1999) Proliferative verrucous leukoplakia and its related lesions. Oral Oncol 35:354–359
Murrah VA, Batsakis JG (1994) Proliferative verrucous leukoplakia and verrucous hyperplasia. Ann Otol Rhinol Laryngol 103:660–663
Silverman Jr S, Gorsky M (1997) Proliferative verrucous leukoplakia: a follow-up study of 54 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 84:154–157
Morton TH, Cabay RJ, Epstein JB (2007) Proliferative verrucous leukoplakia and its progression to oral carcinoma: report of three cases. J Oral Pathol Med 36:315–318
Reichart PA, Philipsen HP (2003) Proliferative verruköse Leukoplakie – Bericht über 5 Fälle. Mund Kiefer Gesichts Chir 7:164–170
Krahl D, Altenburg A, Zouboulis C (2008) Reactive hyperplasias, precancerous and malignant lesions of the oral mucosa. JDDG 6:217–232
Driemel O, Burkhardt A, Hemprich A et al (2008) Erkennung oraler Risikoläsionen in der zahnärztlichen Praxis. Deutsche Krebshilfe e.V. (Hrsg)
Kunkel M, Hertrampf K, Kopp I (2010) Diagnostik und Management von Vorläuferläsionen des oralen Plattenepithelkarzinoms in der Zahn-, Mund- und Kieferheilkunde. Leitlinie der DGZMK/BZÄK/DGMKG 2010. http://www.dgzmk.de/uploads/tx_szdgzmkdocuments/20101201_Langversion_Vorlaeuferlaesionen_des_oralen_Plattenepithelkarzinoms.pdf
Driemel O, Kunkel M, Hullmann M et al (2008) Performance of conventional oral brush biopsies. HNO 56:205–210
Mehrotra R, Hullmann M, Smeets R et al (2009) Oral cytology revisited. J Oral Pathol Med 38:161–166
Hullmann M, Kunkel M, Reichert TE (2010) Diagnostik und Therapie oraler Präkanzerosen. MKG-Chirurg 1:7–15
Frerich B (2010) Standardtherapie von Plattenepithelkarzinomen der Mundhöhle gemäß Leitlinien. MKG-Chirurg 1:16–24
Grötz KA (2003) Dental care for patients with antineoplastic radiotherapy of the head and neck. Strahlenther Onkol 179:275–278
Wittekind C, Meyer HJ (2010) TNM Klassifikation maligner Tumoren, 7. Aufl. UICC International Union Against Cancer. Wiley-VCH, Weinheim
Bootz F, Howaldt HP, Mergenthaler XY, Wendt T (2008) Karzinome des oberen Aerodigestivtraktes. In: Garbe C, Adler G, Beckmann MW et al (Hrsg) Kurzgefasste interdisziplinäre Leitlinien 2008, Deutsche Krebsgesellschaft e. V. W. Zuckerschwerdt, München Wien New York, S 17–18
Woolgar JA, Triantafyllou A (2009) Pitfalls and procedures in the histopathological diagnosis of oral and oropharyngeal squamous cell carcinoma and a review of pathology in prognosis. Oral Oncol 45:361–385
Shah JP, Gil Z (2009) Current concepts in management of oral cancer – surgery. Oral Oncol 45:394–401
Robbins KT, Clayman G, Levine PA et al (2002) American Head and Neck Society; American Academy of Otolaryngology – Head and neck dissection classification update: revisions proposed by the American Head and Neck Society and the American Academy of Otolaryngology – Head and Neck Surgery. Arch Otolaryngol Head Neck Surg 131:965–969
Iype EM, Sebastian P, Mathew A et al (2008) The role of selective neck dissection (I–III) in the treatment of node negative (N0) neck in oral cancer. Oral Oncol 44:1134–1138
Wolff KD (2010) Mikrovaskulärer Gewebetransfer. Bewährte Verfahren und neue Aspekte. MKG-Chirurg 1:30–37
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Hullmann, M., Reichert, T. Aktuelle Konzepte zur Früherkennung, Diagnostik und Therapie oraler Plattenepithelkarzinome. Bundesgesundheitsbl. 54, 1083–1088 (2011). https://doi.org/10.1007/s00103-011-1334-x
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DOI: https://doi.org/10.1007/s00103-011-1334-x
Schlüsselwörter
- Orales Plattenepithelkarzinom
- Präkanzeröse Läsionen
- Präkanzeröse Konditionen
- Tumorchirurgie
- Früherkennung