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Humane embryonale Stammzellen

Perspektiven für die Erforschung und Therapie neurologischer Erkrankungen

Human embryonic stem cells. Perspectives for the study and therapy of neurological disorders

  • Leitthema: Forschung mit humanen embryonalen Stammzellen
  • Published:
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz Aims and scope

Zusammenfassung

Die außergewöhnliche Fähigkeit humaner embryonaler Stammzellen (hES-Zellen), in alle somatischen Zell- und Gewebetypen differenzieren zu können, eröffnet vielversprechende Möglichkeiten für die Entwicklung neuer Ansätze zur Behandlung neurologischer Erkrankungen. Der vorliegende Beitrag soll anhand ausgewählter Beispiele einen Überblick über den derzeitigen Stand der Forschung auf diesem Gebiet geben. Es werden Methoden und Ergebnisse zur Gewinnung ausgewählter neuraler Zelltypen (dopaminerge Neurone, Retinazellen, Motorneurone, Oligodendrozyten) aus hES-Zellen vorgestellt und mögliche Probleme und Risiken der Nutzung dieser neuen Zellquelle im klinischen Kontext diskutiert.

Abstract

The remarkable capability of human embryonic stem cells (hES cells) to differentiate into all somatic cell types and tissues opens promising perspectives for the development of novel therapeutic approaches for neurological disorders. This article provides an overview on the current state of research in this field. We present strategies and results on the generation of selected neural subtypes (dopaminergic neurons, retinal progenitors, motoneurons, oligodendrocytes) and discuss problems and risks associated with a potential clinical application of this novel cell source.

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Authors and Affiliations

  1. Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, BRD

    L. Nolden &  Oliver Brüstle

  2. Institut für Rekonstruktive Neurobiologie, Life & Brain Zentrum, Sigmund-Freud-Straße 25, 53127, Bonn, BRD

    Oliver Brüstle

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  1. L. Nolden
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  2. Oliver Brüstle
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Correspondence to Oliver Brüstle.

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Nolden, L., Brüstle, O. Humane embryonale Stammzellen. Bundesgesundheitsbl. 51, 1026–1032 (2008). https://doi.org/10.1007/s00103-008-0631-5

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  • DOI: https://doi.org/10.1007/s00103-008-0631-5

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