Skip to main content

Advertisement

SpringerLink
Log in

Public Health Genomics

Die Integration genombasierten Wissens in die Public-Health-Forschung, Politik und Gesundheitsversorgung

Public Health Genomics. The integration of genome-based knowledge into public health research, policies and health services

  • Leitthema: Genetik und Gesundheitsforschung, Teil 2
  • Published:
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz Aims and scope

Zusammenfassung

Darf die moderne Medizin alles, was sie kann und bei weitergehendem medizinisch- technischem Fortschritt im Zeitalter der Genomforschung können wird? Welche Entwicklungen sind durch die molekulare Medizin zu erwarten, und wo sind sie zu fördern, wo ihnen Grenzen zu setzen und durch wen? Wo endet die Verantwortung jedes Einzelnen für gesundheitliche Beeinträchtigungen, und wofür hat die Gemeinschaft der Versicherten oder Steuerzahler einzustehen? Was kann die molekulare Medizin konkret zu einer effektiveren und effizienteren Gesundheitsversorgung beitragen, und welche maßgeblichen Weichen der Präventivmedizin, öffentlichen Gesundheitsvorsorge und Gesundheitssicherung können bereits zum jetzigen Zeitpunkt seitens der Sozial und Gesundheitspolitik gestellt werden? Auf all diese Fragen versucht Public Health Genomics (PHG) Antworten zu geben. Die Integration genombasierten Wissens in die Ansätze von Public Health wird Public Health Genomics (PHG) genannt und ist definiert als "the responsible and effective translation of genome-based knowledge and technologies into public policy and health services for the benefit of population health".

Abstract

Which consequences can be drawn from genome-based knowledge and how can it be responsibly and timely translated into policies and practice? What are recent developments in genetics and molecular biology, what are the challenges, what are the risks of these developments? Which policies can provide an acceptable balance between providing strong protection of individuals'interests and needs while enabling society to benefit from the genomic advances and empowering individuals? How can molecular medicine contribute to more effective and efficient health care services, and what infrastructures and policies can already now be implemented to assure a benefit for population health? Thus, Public Health Genomics (PHG) tries to answer these challenging questions. This integration of genomics into the aims of public health is called Public Health Genomics (PHG) and is defined as "the responsible and effective translation of genome-based knowledge and technologies into public policy and health services for the benefit of population health".

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. Brand A (2005) Public health and genetics – a dangerous combination? View-point section. Eur J Public Health 15(2):113–116

    Article  Google Scholar 

  2. Khoury MJ (1996) From genes to public health:the applications of genetic technology in disease prevention. Am J Public Health 86(12):1717–1722

    PubMed  CAS  Google Scholar 

  3. Peltonen L, McKusick VA (2001) Genomics and medicine:dissecting human disease in the postgenomic Era. Science 291:1224–1229

    Article  PubMed  CAS  Google Scholar 

  4. Baird PA (2000) Identification of genetic susceptibility to common diseases:the case for regulation. Perspectives Biol Med 45(4):516–528

    Article  Google Scholar 

  5. IoM (Institute of Medicine) (1988) The future of public health. Division of health care services. Committee for the Study of the Future of Public Health. National Academies Press, Washington D.C., pp 7–8

  6. IoM (Institute of Medicine) (2005) Implications of Genomics for Public Health. Workshop Summary. National Academies Press, Washington D.C., pp 1–67

  7. Beskow LM, Khoury MJ, Baker TG, Thrasher JF (2001) The integration of genomics into public health research, policy and practice in the United States. Community Genet 4:2–11

    Article  PubMed  Google Scholar 

  8. Bellagio Statement (2005) Genome- based research and population health. Report of an expert workshop held at the Rockefeller Foundation Study and Conference Center, Bellagio, Italy, 14–20 April 2005

  9. Burke W, Khoury M, Stewart A, Zimmern R for the Bellagio Group (2006) The path from genomebased research to population health:Development of an international public health genomics network. Genetics Med 8(7):451–458

    Article  Google Scholar 

  10. Ellsworth DL, O’Donnell CJ (2004) Emerging genomic technologies and analytic methods for population- and clinic-based research. In:Khoury MJ, Little J, Burke W (eds) Human genome epidemiology. A scientific foundation for using genetic information to improve health and prevent disease. Oxford University Press, Oxford New York Tokyo, pp 17–37

  11. Little J (2004) Reporting and review of the human genome epidemiology Studies. In:Khoury MJ, Little J, Burke W (eds) Human genome epidemiology. A scientific foundation for using genetic information to improve health and prevent disease. Oxford University Press, Oxford New York Tokyo, pp 168–192

  12. Brand A, Dabrock P, Paul N, Schröder P (2004) Gesundheitssicherung im Zeitalter der Genomforschung – Diskussion, Aktivitäten und Institutionalisierung von Public Health Genetics in Deutschland. Gutachtenreihe Bio- und Gentechnologie, Friedrich-Ebert-Stiftung, S 3–62

  13. Rabatta S (2002) Biobanken – Eine Frage des Umgangs. Dtsch Ärztebl 99(27):A1863–1864

    Google Scholar 

  14. Murray T (1997) Genetic exceptionalism and future diaries:is genetic information different from other medical information? In: Rothstein M (ed) Genetic secrets:protecting privacy and confidentiality in the genetic era. Yale University Press, New Haven, pp 60–73

  15. Schröder P (im Druck) Der Status Genom-basierter Informationen. Public Health Genomics und die These des genetischen Exzeptionalismus. Bundesgesundheitsblatt

  16. Council of Europe (1997) Convention for the protection of human rights and dignity of the human being with regard to the application of biology and medicine. European Treaty Series No. 164

  17. Centers for Disease Control and Prevention (CDC) (2001) Updated guidelines for evaluating public health surveillance systems:recommendations from the guidelines working group. Morbidity Mortality Weekly Report 50(13):1–35

    Google Scholar 

  18. Romaguera RA, German RR, Klaucke DN (2000) Evaluating public health surveillance. In:Teutsch SM, Churchill RE (eds) Principles and practice of Public Health surveillance. Oxford University Press, New York, pp 164–199

  19. Hellmeier W, Jöckel K-H (2005) Monitoring und Surveillance. In:Fehr R, Neus H, Heudorf U (Hrsg) Gesundheit und Umwelt. Ökologische Prävention und Gesundheitsförderung. Hans Huber, Bern, S 168–181

  20. Thacker SB, Stroup DF, Parrisch RG (1996) Surveillance in environmental Public Health:issues, systems, and sources. Am J Publ Health 86(5):633– 638

    Article  CAS  Google Scholar 

  21. Brand A, Schröder P, Brand H, Zimmern R (2006) Getting ready for the future:integration of genomics into public health research, policy and practice in Europe and globally. Community Genet 9:67–71

    Article  PubMed  Google Scholar 

  22. Brand A, Brand B (im Druck) Genetik in Gesundheitsforschung und Public Health. Bundesgesundheitsblatt

  23. Bosch X (2006) Group ponders genomics and public health. JAMA 295(15):1762

    Article  PubMed  CAS  Google Scholar 

  24. Brand A, Dabrock P, Gibis B (2003) Neugeborenen- Screening auf angeborene Stoffwechselstörungen und Endokrinopathien – aktuelle ethische Fragen aus unterschiedlichen Perspektiven. In:Wiesemann C, Dörries A, Wolflast G, Simon A (Hrsg) Das Kind als Patient – Ethische Konflikte zwischen Kindeswohl und Kindeswille. Campus, Frankfurt/M, S 217–233

  25. Bundesministerium für Gesundheit und Soziale Sicherung (2004) Bekanntmachung eines Beschlusses des Gemeinsamen Bundesausschusses über eine Änderung der Richtlinien des Bundesausschusses der Ärzte und Krankenkassen über die Früherkennung von Krankheiten bei Kindern bis zur Vollendung des 6. Lebensjahres (Kinder-Richtlinien) zur Einführung des erweiterten Neugeborenenscreenings. BAnz. Nr.–60 vom 31. 3. 2005, S 4833

  26. Deutsche Gesellschaft für Neugeborenenscreening (2006) Nationaler Screeningreport 2004. http://screening-dgns.de (letzter Zugriff 19. 8. 2006)

  27. Annas GJ (2000) Rules for research on human genetic variation – lessons from Iceland. NEJM 342:1830–1833

    Article  PubMed  CAS  Google Scholar 

  28. Daar AS (2002) Top 10 biotechnologies for improving health in developing countries. Nature Genetics 32(2):229–232

    Article  PubMed  CAS  Google Scholar 

  29. Haga SB, Khoury MJ, Burke W (2003) Genomic profiling to promote a healthy lifestyle:not ready for prime time. Nature Genetics 34(4):347–350

    Article  PubMed  CAS  Google Scholar 

  30. Smith GD, Ebrahim S, Lewis S et al. (2005) Genetic epidemiology and public health:hope, hype, and future prospects. Lancet 366:1484–1498

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Landesinstitut für den Öffentlichen Gesundheitsdienst NRW (lögd), Bielefeld, BRD

    Helmut Brand MSc MFPH

  2. Deutsches Zentrum für Public Health Genomics (DZPHG), Bielefeld, BRD

    A. Brand MPH

  3. Landesinstitut für den Öffentlichen Gesundheitsdienst NRW (lögd), Westerfeldstraße 35–37, 33611, Bielefeld, BRD

    Helmut Brand MSc MFPH

Authors
  1. Helmut Brand MSc MFPH
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Brand MPH
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Helmut Brand MSc MFPH.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brand, H., Brand, A. Public Health Genomics. Bundesgesundheitsbl. 50, 135–144 (2007). https://doi.org/10.1007/s00103-007-0134-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00103-007-0134-9

Schlüsselwörter

Keywords

Search

Navigation