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Nutrigenomik

Grundlagen, Stand der Forschung, Anwendungen

Nutrigenomics. Scientific basis, status and perspectives of application

  • Leitthema: Genetik und Gesundheitsforschung, Teil 1: Grundlagen
  • Published:
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz Aims and scope

Zusammenfassung

Nutrigenomik ist eine neue Forschungsrichtung, die die Wechselwirkung zwischen der Ernährung und dem Genom untersucht und damit Ernährungswissenschaft und funktionelle Genomik zusammenführt. Ziel der Nutrigenomik ist es, (1) heterogene Effekte von Nährstoffen auf Sequenz variationen im Genom zurückzuführen sowie (2) durch Einsatz neuer Untersuchungstechniken die Wirkungen von Nahrungsinhaltsstoffen auf die Expression des gesamten Genoms (mRNA profiling) und auf Metabolitenmuster (metabolite profiling) zu untersuchen. Hierdurch werden wichtige Erkenntnisse zur Funktion von Lebensmittelinhaltsstoffen sowie zur funktionellen Konsequenz genetischer Varianz gewonnen. Diese werden eine verbesserte Prävention ernährungsbedingter Erkrankungen, z. B. durch eine personalisierte Ernährung, ermöglichen.

Abstract

Nutrigenomics investigates the interaction between nutrition and the genome, thereby combining nutritional research with functional genomics. Its aims are (1) to correlate heterogeneous effects of nutrients with sequence variations in the genome and (2) to investigate the effects of nutrients and other food components on gene expression at a genome-wide scale (mRNA profiling), and on patterns of metabolite alterations in serum (metabolite profiling). The field will provide important information as to the biological effects of food components, and to the functional consequences of genetic variance. This information will improve the prevention of nutrition-related diseases, e. g. by establishing personalised nutritional recommendations.

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Authors and Affiliations

  1. Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke, Nuthetal, BRD

    H.-G. Joost

  2. Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114–116, 14558, Nuthetal, BRD

    H.-G. Joost

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  1. H.-G. Joost
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Correspondence to H.-G. Joost.

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Joost, HG. Nutrigenomik. Bundesgesundheitsbl. 49, 1011–1019 (2006). https://doi.org/10.1007/s00103-006-0047-z

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  • DOI: https://doi.org/10.1007/s00103-006-0047-z

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