Literatur
Tacconelli E et al (2018) Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. Lancet Infect Dis 18(3):318–327
Ito A et al (2016) Siderophore Cephalosporin Cefiderocol utilizes ferric iron transporter systems for antibacterial activity against pseudomonas aeruginosa. Antimicrob Agents Chemother 60(12):7396–7401
Page MGP (2019) The role of iron and siderophores in infection, and the development of siderophore antibiotics. Clin Infect Dis 69(Suppl 7):S529–S537
Longshaw C et al (2020) In vitro activity of the siderophore cephalosporin, cefiderocol, against molecularly characterized, carbapenem-non-susceptible Gram-negative bacteria from Europe. JAC Antimicrob Resist 2(3):dlaa60
Portsmouth S et al (2018) Cefiderocol versus imipenem-cilastatin for the treatment of complicated urinary tract infections caused by Gram-negative uropathogens: a phase 2, randomised, double-blind, non-inferiority trial. Lancet Infect Dis 18(12):1319–1328
Wunderink RG et al (2021) Cefiderocol versus high-dose, extended-infusion meropenem for the treatment of Gram-negative nosocomial pneumonia (APEKS-NP): a randomised, double-blind, phase 3, non-inferiority trial. Lancet Infect Dis 21(2):213–225
Bassetti M et al (2021) Efficacy and safety of cefiderocol or best available therapy for the treatment of serious infections caused by carbapenem-resistant Gram-negative bacteria (CREDIBLE-CR): a randomised, open-label, multicentre, pathogen-focused, descriptive, phase 3 trial. Lancet Infect Dis 21(2):226–240
Paul M et al (2018) Colistin alone versus colistin plus meropenem for treatment of severe infections caused by carbapenem-resistant Gram-negative bacteria: an open-label, randomised controlled trial. Lancet Infect Dis 18(4):391–400
Naseer S et al (2021) US Food and Drug Administration (FDA): benefit-risk considerations for cefiderocol (Fetroja(R)). Clin Infect Dis 72(12):e1103–e1111
Karakonstantis S, Rousaki M, Kritsotakis EI (2022) Cefiderocol: systematic review of mechanisms of resistance, heteroresistance and in vivo emergence of resistance. Antibiotics 11(6):723. https://doi.org/10.3390/antibiotics11060723
Smoke SM et al (2022) Evolution and transmission of cefiderocol-resistant Acinetobacter baumannii during an outbreak in the burn intensive care unit. Clin Infect Dis 6(3):e1261–e1265. https://doi.org/10.1093/cid/ciac647
Wang Q et al (2022) Occurrence of high levels of cefiderocol resistance in carbapenem-resistant escherichia coli before its approval in China: a report from China CRE-network. Microbiol Spectr 10(3):e267021
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L. Mehringer gibt an Vortragshonorar von MSD Sharp & Dohme GmbH erhalten zu haben. U. Seybold und M. Zoller geben an, dass kein Interessenkonflikt besteht.
Für diesen Beitrag wurden von den Autor/-innen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.
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Mehringer, L., Seybold, U. & Zoller, M. Was ist neu … Cefiderocol. Anaesthesiologie 72, 189–190 (2023). https://doi.org/10.1007/s00101-023-01252-w
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DOI: https://doi.org/10.1007/s00101-023-01252-w