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Ventilations-Perfusions-Verteilungen in der Lunge

Eine neue Technik zur schnellen Bestimmung

Ventilation-perfusion distributions in the lungs

A novel technique for rapid measurement

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Zusammenfassung

Die Multiple-Inertgas-Eliminationstechnik (MIGET) stellt den Goldstandard zur Bestimmung der Ventilations- und Perfusionsverteilungen in der Lunge dar. Eine Modifikation in deren Durchführung erlaubt eine wesentlich einfachere und schnellere Handhabung, sodass diese aufwendige Methode erstmals für den klinischen Routineeinsatz geeignet erscheint. Die MIGET mithilfe der „micropore membrane inlet mass spectrometry“ (MMIMS) stellt damit eine frühere Detektion von Lungenerkrankungen und ein sensitiveres Therapiemonitoring in Aussicht.

Abstract

The multiple inert gas elimination technique (MIGET) represents the gold standard for analysis of ventilation and perfusion distributions in the lung. Modification of this technique allows a much simpler sample processing and hence permits routine clinical application of this technique. MIGET using micropore membrane inlet mass spectrometry (MMIMS) might, therefore, facilitate early diagnosis of lung diseases and monitoring of therapeutic interventions in the future.

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Interessenkonflikt

Für die Autoren B. Dünges, J. Karmrodt und K. Markstaller besteht kein Interessenkonflikt. Die Multiple-Inertgas-Eliminationstechnik mithilfe der Micropore membrane inlet mass spectrometry steht der Johannes-Gutenberg-Universität, Mainz, als Leihgabe der Deutschen Forschungsgemeinschaft (DFG Ma2398/3) zur Verfügung. Dr. James E. Baumgardner ist Gechäftsführer der Fa. Oscillogy LLC, Folsom USA, die das in diesem Artikel beschriebene MMIMS-MIGET-Gerät kommerziell vertreibt.

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Authors and Affiliations

  1. Klinik für Anästhesiologie, Johannes-Gutenberg-Universität, Langenbeckstr. 1, 55131, Mainz, Deutschland

    B. Dünges, J. Karmrodt & K. Markstaller

  2. Department of Anesthesiology and Critical Care Medicine, University of Pennsylvania, Philadelphia, PA, USA

    J.E. Baumgardner

  3. Fa. Oscillogy LLC, Folsom, PA, USA

    J.E. Baumgardner

Authors
  1. B. Dünges
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  2. J. Karmrodt
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  3. J.E. Baumgardner
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  4. K. Markstaller
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Corresponding author

Correspondence to B. Dünges.

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Dünges, B., Karmrodt, J., Baumgardner, J. et al. Ventilations-Perfusions-Verteilungen in der Lunge. Anaesthesist 56, 612–616 (2007). https://doi.org/10.1007/s00101-007-1190-0

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  • DOI: https://doi.org/10.1007/s00101-007-1190-0

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