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Pulmonary embolism following severe polytrauma: a retrospective study from a level I trauma center in China

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Abstract

Background

Trauma patients are at high risk of Venous thromboembolism (VTE), but compared to well-established deep venous thrombosis (DVT), data specifically evaluating post-traumatic pulmonary embolism (PE) are scarce. The aim of this study is to assess whether PE represents a distinct clinical entity with injury pattern, risk factors, and prophylaxis strategy different from DVT, among severe poly-trauma patients.

Patients and methods

We retrospectively enrolled patients admitted to our level I trauma center from January 2011 to December 2021 who were diagnosed with severe multiple traumatic injuries and identified thromboembolic events among them. We regarded four groups as None (without thromboembolic events), DVT only, PE only, and PE with DVT. Demographics, injury characteristics, clinical outcomes, and treatments were collected and analyzed in individual groups. Patients were also classified according to the occurring time of PE, and indicative symptoms and radiological findings were compared between early PE (≤ 3 days) and late PE (> 3 days). Logistic regression analyses were conducted to explore independent risk factors for different VTE patterns.

Results

Among 3498 selected severe multiple traumatic patients, there were 398 episodes of DVT only, 19 of PE only, and 63 of PE with DVT. Injury variables associated with PE only included shock on admission and severe chest trauma. Severe pelvic fracture and mechanical ventilator days (MVD) ≥ 3 were the independent risk factors for PE with DVT. There were no significant differences in the indicative symptoms and location of pulmonary thrombi between the early and late PE groups. Obesity and severe lower extremity injury might have an impact on the incidence of early PE, while patients with a severe head injury and higher ISS are particularly at risk for developing late PE.

Conclusion

Occurring early, lacking association with DVT, and possessing distinct risk factors warrant PE in severe poly-trauma patients special attention, especially for its prophylaxis strategy.

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Funding

The authors would like to acknowledge the support of the National Natural Science Foundation of China (No. 82102270).

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Author notes

  1. Qiqi Wu and Jie Wu have equally contributed to the work and should be regarded as co-first authors.

Authors and Affiliations

  1. Department of Trauma Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China

    Qiqi Wu, Shufen Tian, Wei Gao, Zhanfei Li, Xiangjun Bai & Tao Liu

  2. Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China

    Jie Wu

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Correspondence to Tao Liu.

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The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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The Ethical Committee of Tongji Hospital affiliated with Huazhong University of Science and Technology, Wuhan, China, approved the research and provided a waiver for retrospective data collection.

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Wu, Q., Wu, J., Tian, S. et al. Pulmonary embolism following severe polytrauma: a retrospective study from a level I trauma center in China. Eur J Trauma Emerg Surg 49, 1959–1967 (2023). https://doi.org/10.1007/s00068-023-02290-0

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