Skip to main content

Advertisement

SpringerLink
Log in

Serum levels of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in predicting the severity of acute pancreatitis

  • Original Article
  • Published:
European Journal of Trauma and Emergency Surgery Aims and scope Submit manuscript

Abstract

Introduction

Acute pancreatitis (AP) is a severe disease associated with significant morbidity and mortality. The overall outcome has improved, but specific treatment(s) remains elusive. The challenge is the early identification and treatment of patients who will develop severe acute pancreatitis. Therefore, the aim of the present study is to investigate plasma levels of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in the initial phase of predicted severe acute pancreatitis.

Methods

Between June 2014 and January 2016, 64 patients with acute pancreatitis and 36 healthy individuals were included to study. Four blood samples, for serum TWEAK measurement, were taken from each individual in each group. The first measurement was taken from the admission blood sample. The subsequent three samples were taken at 12, 24, and 48 h after the hospital admission.

Results

Serum TWEAK levels were significantly higher in patients with acute pancreatitis when compared with healthy controls. TWEAK plasma concentrations in severe pancreatitis patients were significantly higher than in mild pancreatitis patients.

Conclusion

Serum TWEAK levels increase progressively with the severity of acute pancreatitis and TWEAK might be a novel early marker of severity in acute pancreatitis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Flint RS, Phillips AR, Farrant GJ, McKay D, Buchanan CM, Cooper GS, Windsor JA (2007) Probing the urinary proteome of severe acute pancreatitis. HPB (Oxford) 9(6):447–55.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Peng YS, Chen YC, Tian YC, Yang CW, Lien JM, Fang JT, Wu CS, Hung CF, Hwang TL, Tsai YH, Lee MS, Tsai MH.Serum levels of apolipoprotein A-I and high-density lipoprotein can predict organ failure in acute pancreatitis. Crit Care. 2015; 19:88.

    Article  Google Scholar 

  3. Ferat-Osorio E, Wong-Baeza I, Esquivel-Callejas N, Figueroa-Figueroa S, Duarte-Rojo A, Guzmán-Valdivia-Gómez G, Rodea-Rosas H, Torres-González R, Sánchez-Fernández P, Arriaga-Pizano L, López-Macías C, Robles-Díaz G, Isibasi A. Triggering receptor expressed on myeloid cells-1 expression on monocytes is associated with inflammation but not with infection in acute pancreatitis. Crit Care. 2009;13(3):R69.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, et al. Classification of acute pancreatitis—2012: revision of the Atlanta classification and definitions by international consensus. Gut. 2013;62(1):102–11.

    Article  PubMed  Google Scholar 

  5. Rahman SH, Menon KV, Holmfield JH, McMahon MJ, Guillou JP. Serum macrophage migration inhibitory factor is an early marker of pancreatic necrosis in acute pancreatitis. Ann Surg. 2007 Feb;245(2):282–9.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Chen T, Guo ZP, Li MM, Li JY, Jiao XY, Zhang YH, Liu HJ. Tumour necrosis factor-like weak inducer of apoptosis (TWEAK), an important mediator of endothelial inflammation, is associated with the pathogenesis of Henoch-Schonlein purpura. Clin Exp Immunol. 2011 Oct;166(1):64–71.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Maymó-Masip E, Fernández-Veledo S, Garcia España A, Vázquez-Carballo A, Tinahones FJ, García-Fuentes E, Garrifo-Sanchez L, Rodriguez Mdel M, Vendrell J. Chacón MR.The rise of soluble TWEAK levels in severely obese subjects after bariatric surgery may affect adipocyte-cytokine production induced by TNFα. J Clin Endocrinol Metab. 2013 Aug;98(8):E1323–33.

    Article  CAS  PubMed  Google Scholar 

  8. Balthazar EJ. Acute Pancreatitis: Assessment of Severity with Clinical and CT Evaluation. Radiology. 2002;223(3):603–13.

    Article  PubMed  Google Scholar 

  9. Schnúr A, Hegyi P, Rousseau S, Lukacs GL, Veit G. Epithelial Anion Transportas Modulator of Chemokine Signaling. Mediators Inflamm. 2016;2016:7596531.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Bhatia M, Brady M, Shokuhi S, Christmas S, Neoptolemos JP, Slavin J. Inflammatory mediators in acute pancreatitis. J Pathol. 2000 Feb;190(2):117–25.

    Article  CAS  PubMed  Google Scholar 

  11. Bhatia M, Wong FL, Cao Y, Lau HY, Huang J, Puneet P, Chevali L. Pathophysiology of acute pancreatitis. Pancreatology. 2005;5(2–3):132–44.

    Article  PubMed  Google Scholar 

  12. Bhatia M, Moochhala S. Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. J Pathol. 2004 Feb;202(2):145–56.

    Article  CAS  PubMed  Google Scholar 

  13. Burkly LC. Regulation of tissue responses: the TWEAK/Fn14 pathway and other TNF/TNFR superfamily members that activate non-canonical NFκB signaling. Front Immunol. 2015;6:92.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Cho JH, Kim TN, Chung HH, Kim KH. Comparison of scoring systems in predicting the severity of acute pancreatitis. World J Gastroenterol. 2015;Feb 28;21(8):2387–94.

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of General Surgery, Ankara Numune Training and Research Hospital, 7. Cadde 70A /14, 06490-Bahcelievler, Ankara, Turkey

    Baris Zulfikaroglu & Ozgur Akgul

  2. Department of Clinical Chemistry, Goztepe Training and Research Hospital, Istanbul Medeniyet University, Istanbul, Turkey

    Ferruh Kemal Isman

  3. Department of General Surgery, Medical Park Ankara Hospital, Ankara, Turkey

    Gul Bora & Necdet Ozalp

Authors
  1. Baris Zulfikaroglu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ferruh Kemal Isman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Gul Bora
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ozgur Akgul
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Necdet Ozalp
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Baris Zulfikaroglu.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zulfikaroglu, B., Isman, F.K., Bora, G. et al. Serum levels of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in predicting the severity of acute pancreatitis. Eur J Trauma Emerg Surg 45, 539–543 (2019). https://doi.org/10.1007/s00068-018-0938-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00068-018-0938-3

Keywords

Search

Navigation