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Colonoscopic decompression should be used before neostigmine in the treatment of Ogilvie’s syndrome

Abstract

Background

Performance of urgent colonoscopy for the purposes of diagnosis and treatment of Ogilvie’s syndrome remains controversial. However, no trials have directly compared neostigmine with endoscopic therapy. This study aimed to compare the effect of neostigmine and colonoscopic decompression in the treatment of Ogilvie’s syndrome.

Methods

This study was designed as a retrospective, non-randomized clinical study of sequential patients. Patients who were diagnosed as having acute colonic pseudo-obstruction were separated into two groups after conservative treatment. Group 1 comprised patients who underwent colonoscopic decompression, because they had a poor first response to neostigmine treatment. Group 2 constituted patients who had a poor first response to colonoscopic decompression, and neostigmine was added to the treatment regimen. Groups 1 and 2 were compared for the success of disease management.

Results

In groups 1 and 2, the average age of the patients was 63.19 years (±14.71 years) and 59.45 years (±15.31 years) (p = 0.312), respectively. No significant difference was determined between the groups in terms of distribution of sex, hospital stay, etiologies, and initial cecal sizes in imaging (p > 0.05). Response to first intervention was statistically significant (p < 0.01). Also, the total response was determined statistically significant for hospital stay if colonoscopic decompression was performed (p < 0.01). No recurrence was determined during the 1-month follow-up in both groups. Although there was no etiologic factor for neostigmine response according to univariate analysis results, colonoscopic success was decreased due to age, sex, and the presence of a cardiac disease.

Conclusions

Although the success rate of neostigmine treatment was significantly lower in our homogeneous groups, no significant decrease was determined in terms of hospital stay, intensive care unit stay, and requirement of colostomy compared with colonoscopic decompression. By comparison, colonoscopic decompression, which was performed by experienced endoscopists as a first-line treatment option, was more effective as an initial therapy and was more effective at avoiding a second treatment modality.

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Abbreviations

PEG:

Polyethylene glycol

ASGE:

American Society for Gastrointestinal Endoscopy

ACPO:

Acute colonic pseudo-obstruction

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Acknowledgments

We would like to thank Mr. David F. Chapman for his assistance with the language in the manuscript.

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Correspondence to K. D. Peker.

Ethics declarations

Ethics committee approval was received for this study from the ethics committee of Istanbul Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey (Decision No.: 168; Date: 02.08.2014).

Conflict of interest

Kivanc Derya Peker, Murat Cikot, Mehmet Abdussamet Bozkurt, Burak Ilhan, Burak Kankaya, Sinan Binboga, Hakan Seyit and Halil Alis declare that they have no conflict of interest.

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Peker, K.D., Cikot, M., Bozkurt, M.A. et al. Colonoscopic decompression should be used before neostigmine in the treatment of Ogilvie’s syndrome. Eur J Trauma Emerg Surg 43, 557–566 (2017). https://doi.org/10.1007/s00068-016-0709-y

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  • DOI: https://doi.org/10.1007/s00068-016-0709-y

Keywords

  • Acute colonic pseudo-obstruction
  • Colonoscopic decompression
  • Ogilvie’s syndrome
  • Neostigmine