Skip to main content
Log in

Einfluss der Fraktionierung (1 × 24 Gy vs. 3 × 9 Gy) auf onkologische Endpunkte bei der SBRT von Oligometastasen

Influence of fractionation (single dose 24Gy vs. 3 fractions of 9Gy) on oncological end points in SBRT of oligometastases

  • Literatur kommentiert
  • Published:
Strahlentherapie und Onkologie Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Literatur

  1. Palma DA, Olson R, Harrow S et al (2019) Stereotactic ablative radiotherapy versus standard of care palliative treatment in patients with oligometastatic cancers (SABR-COMET): a randomised, phase 2, open-label trial. Lancet 393:2051–2058

    Article  Google Scholar 

  2. Song CW, Glatstein E, Marks LB et al (2019) Biological principles of Stereotactic body radiation therapy (SBRT) and Stereotactic radiation surgery (SRS): indirect cell death. Int J Radiat Oncol Biol Phys. https://doi.org/10.1016/j.ijrobp.2019.02.047

    Article  PubMed  PubMed Central  Google Scholar 

  3. Greco C, Pares O, Pimentel N et al (2019) Phenotype-oriented ablation of Oligometastatic cancer with single dose radiation therapy. Int J Radiat Oncol Biol Phys 104:593–603

    Article  Google Scholar 

  4. Ghia AJ, Chang EL, Bishop AJ et al (2016) Single-fraction versus multifraction spinal stereotactic radiosurgery for spinal metastases from renal cell carcinoma: secondary analysis of Phase I/II trials. J Neurosurg Spine 24:829–836

    Article  Google Scholar 

  5. Garcia-Barros M, Paris F, Cordon-Cardo C et al (2003) Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science 300:1155–1159

    Article  CAS  Google Scholar 

  6. Bodo S, Campagne C, Thin TH et al (2019) Single-dose radiotherapy disables tumorcell homologous recombination via ischemia/reperfusion injury. J Clin Invest 129:786–801

    Article  Google Scholar 

  7. Greco C, Zelefsky MJ, Lovelock M et al (2011) Predictors of local control after single-dose stereotactic image-guided intensity-modulated radiotherapy for extracranial metastases. Int J Radiat Oncol Biol Phys 79:1151–1157

    Article  Google Scholar 

  8. Phillips R, Shi WY, Deek M et al (2020) Outcomes of observation vs Stereotactic ablative radiation for oligometastatic prostate cancer: the ORIOLE phase 2 randomized clinical trial. JAMA Oncol 6:650–659

    Article  Google Scholar 

  9. Hussain M, Fizazi K, Saad F et al (2018) Enzalutamide in men with nonmetastatic, castration-resistant prostate cancer. N Engl J Med 378:2465–2474

    Article  CAS  Google Scholar 

  10. Zeng KL, Tseng CL, Soliman H et al (2019) Stereotactic body radiotherapy (SBRT) for oligometastatic spine metastases: an overview. Front Oncol 9:337

    Article  Google Scholar 

  11. Sahgal A, Atenafu EG, Chao S et al (2013) Vertebral compression fracture after spine stereotactic body radiotherapy: a multi-institutional analysis with a focus on radiation dose and the spinal instability neoplastic score. J Clin Oncol 31:3426–3431

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Robert-Michael Hermann.

Ethics declarations

Interessenkonflikt

R.-M. Hermann, H. Christiansen und M. Bremer geben an, dass kein Interessenkonflikt besteht.

Additional information

Originalpublikation

Zelefsky MJ, Yamada Y, Greco C et al (2021) Phase III multi-center, prospective, randomized trial comparing single dose 24 Gy radiotherapy to a 3-fraction SBRT regimen in the treatment of oligometastatic cancer. Int J Radiat Oncol Biol Phys, https://doi.org/10.1016/j.ijrobp.2021.01.004. Online ahead of print

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hermann, RM., Christiansen, H. & Bremer, M. Einfluss der Fraktionierung (1 × 24 Gy vs. 3 × 9 Gy) auf onkologische Endpunkte bei der SBRT von Oligometastasen. Strahlenther Onkol 197, 661–663 (2021). https://doi.org/10.1007/s00066-021-01786-1

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00066-021-01786-1

Navigation