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Toxicity outcome of endorectal brachytherapy boost in medically inoperable patients

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Abstract

Aim

This communication reviews results and toxicity of image-guided high-dose-rate endorectal brachytherapy (HDREBT) boost after external beam radiotherapy (ERT) in medically inoperable patients with rectal cancer.

Materials and methods

A total of 18 patients with rectal cancer and clinical stage T2-4N0‑2 treated with HDREBT boost after ERT were retrospectively reviewed.

Results

Following treatment with a median total dose (EQD2, α/β = 10) of 66 Gy (range 48–92 Gy), the incidence of early and late rectal grade 3 toxicity was 11% and 19%, respectively. There was no correlation between the occurrence of acute and late toxicity.

Conclusion

With proper technique, a combined approach using EBRT and HDREBT was associated with acceptable toxicity in medically inoperable rectal cancer patients.

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Funding sources

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Clinical Oncology, Tuen Mun Hospital, Hong Kong, China

    CL Chiang, SF Lee, Venus WY Lee, Cynthia SY Yeung, Steven KT Cheung, Francis AS Lee, Frank CS Wong & Mark KH Chan

  2. Department of Clinical Oncology, University of Hong Kong, Hong Kong, China

    CL Chiang & KO Lam

  3. Department of Clinical Oncology, Queen Mary Hospital, Hong Kong, China

    CL Chiang & KO Lam

  4. Department of Surgery, Tuen Mun Hospital, Hong Kong, China

    Michael CM Poon

  5. Department of Surgery, Queen Mary Hospital, Hong Kong, China

    Dominic CC Foo & SH Lo

  6. Clinic for Radiation Oncology, University Hospital Essen, Essen, Germany

    Mark KH Chan

Authors
  1. CL Chiang
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  2. SF Lee
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  3. Venus WY Lee
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  4. Cynthia SY Yeung
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  5. Steven KT Cheung
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  6. Michael CM Poon
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  7. Dominic CC Foo
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  8. SH Lo
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  9. KO Lam
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  10. Francis AS Lee
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  11. Frank CS Wong
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  12. Mark KH Chan
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Corresponding author

Correspondence to CL Chiang.

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Conflict of interest

C.L. Chiang, S.F. Lee, V.W.Y. Lee, C.S.Y. Yeung, S.K.T. Cheung, M.C.M. Poon, D.C.C. Foo, S.H. Lo, K.O. Lam, F.A.S. Lee, F.C.S. Wong, and M.K.H. Chan declare that they have no competing interests.

This retrospective study has been approved by the University of Hong Kong and Hospital Authority Hong Kong West Cluster (HKU/HA HKW IRB). This has been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Chiang, C., Lee, S., Lee, V. et al. Toxicity outcome of endorectal brachytherapy boost in medically inoperable patients. Strahlenther Onkol 196, 993–997 (2020). https://doi.org/10.1007/s00066-020-01612-0

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  • DOI: https://doi.org/10.1007/s00066-020-01612-0

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