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Strahlentherapie und Onkologie

, Volume 195, Issue 4, pp 308–309 | Cite as

Reply to the letter to the editor “Comment to ‘Impact of postmastectomy radiotherapy on the outcomes of breast cancer patients with T1-2 N1 disease; an individual patient data analysis of three clinical trials’”

  • Omar Abdel-RahmanEmail author
Letter to the Editor
  • 108 Downloads

Dear Editor

Thank you so much for giving me the opportunity to reply the letter to the editor published in regard to my manuscript published previously in Strahlentherapie und Onkologie [ 1]. I, however, have to highlight the following points:
  1. 1.

    The authors of the letter to the editor stated that my conclusions are: “Postmastectomy radiotherapy in T1-2 N1 breast cancer patients who have received modern chemotherapy drugs, does not provide any benefit for overall and disease-free survival.” In fact, my conclusions—as clarified in the abstract—are: “The current analysis does not show a beneficial impact of PMRT on overall or relapse-free survival among patients with T1–T2 N1 disease who received standard adjuvant systemic therapy. There is, however, evidence of improvement in locoregional relapse-free survivalwith PMRT.” So, the study did not tackle disease-free survival but rather relapse-free survival (which is a completely different concept). Moreover, the study did not deny some...

Notes

Conflict of interest

O. Abdel-Rahman declares that he has no competing interests.

References

  1. 1.
    Abdel-Rahman O (2018) Impact of postmastectomy radiotherapy on the outcomes of breast cancer patients with T1-2 N1 disease : an individual patient data analysis of three clinical trials. Strahlenther Onkol.  https://doi.org/10.1007/s00066-018-1343-x CrossRefPubMedGoogle Scholar
  2. 2.
    Ebctcg MP, Taylor C et al (2014) Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials. Lancet 383:2127–2135CrossRefGoogle Scholar
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    Poortmans PM, Collette S, Kirkove C et al (2015) Internal mammary and medial supraclavicular irradiation in breast cancer. N Engl J Med 373:317–327CrossRefPubMedGoogle Scholar
  4. 4.
    Whelan TJ, Olivotto IA, Parulekar WR et al (2015) Regional nodal irradiation in early-stage breast cancer. N Engl J Med 373:307–316CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Clinical Oncology Department, Faculty of MedicineAin Shams UniversityCairoEgypt
  2. 2.Department of Oncology, Tom Baker Cancer CentreUniversity of CalgaryCalgaryCanada

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