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MRI-based high-precision irradiation in an orthotopic pancreatic tumor mouse model

A treatment planning study

MRT-basierte Hochpräzisionsstrahlentherapie im orthotopen Pankreastumor-Mausmodell

Eine Bestrahlungsplanungsstudie

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Abstract

Background and purpose

Recently, imaging and high-precision irradiation devices for preclinical tumor models have been developed. Image-guided radiation therapy (IGRT) including innovative treatment planning techniques comparable to patient treatment can be achieved in a translational context. The study aims to evaluate magnetic resonance imaging/computed tomography (MRI/CT)-based treatment planning with different treatment techniques for high-precision radiation therapy (RT).

Materials and methods

In an orthotopic pancreatic cancer model, MRI/CT-based radiation treatment planning was established. Three irradiation techniques (rotational, 3D multifield, stereotactic) were performed with the SARRP system (Small Animal Radiation Research Platform, Xstrahl Ltd., Camberley, UK). Dose distributions in gross tumor volume (GTV) and organs at risk (OAR) were analyzed for each treatment setting.

Results

MRI with high soft tissue contrast improved imaging of GTV and OARs. Therefore MRI-based treatment planning enables precise contouring of GTV and OARs, thus, providing a perfect basis for an improved dose distribution and coverage of the GTV for all advanced radiation techniques.

Conclusion

An MRI/CT-based treatment planning for high-precision IGRT using different techniques was established in an orthotopic pancreatic tumor model. Advanced radiation techniques allow considering perfect coverage of GTV and sparing of OARs in the preclinical setting and reflect clinical treatment plans of pancreatic cancer patients.

Zusammenfassung

Hintergrund und Zielsetzung

Die aktuelle Entwicklung bildgebender Verfahren und moderner Setups der Hochpräzisionsstrahlentherapie speziell für Kleintiere als präklinische Tumormodelle ermöglicht innovative bildgeführte Bestrahlungstechniken und Bestrahlungsplanung wie in der Therapie menschlicher Patienten sowie Dosisapplikation mit höchster Zielgenauigkeit. Das Ziel dieser Arbeit ist die Evaluation einer Magnetresonanztomographie-/Computertomographie(MRT/CT)-gestützten Bestrahlungsplanung mit verschiedenen Bestrahlungstechniken zur Hochpräzisionsstrahlentherapie.

Methoden

In einem orthotopen Pankreastumor-Mausmodell wurde eine MRT-/CT-basierte Bestrahlungsplanung etabliert. Drei Bestrahlungstechniken (Rotations-, 3‑D-Mehrfeld, stereotaktische Bestrahlung) wurden mit dem SARRP (Small Animal Radiation Research Platform, Fa. Xstrahl Ltd., Camberley, UK) durchgeführt. Die Analyse der Dosisverteilung im makroskopischen Tumorvolumen („gross tumor volume“, GTV) sowie der Risikoorgane erfolgte für jedes einzelne Bestrahlungssetting.

Ergebnisse

Durch die Ergänzung der Bildgebung mittels MRT mit höherem Weichteilkontrast verbesserte sich die Darstellung des GTV und aller Risikoorgane. Die MRT-basierte Bestrahlungsplanung ermöglicht dadurch ein exaktes Konturieren von Tumorvolumen und Risikoorganen als perfekte Basis für eine verbesserte Dosisverteilung und Abdeckung des Zielvolumens in allen Bestrahlungstechniken im präklinischen Tumor-Mausmodell.

Schlussfolgerung

Mit Einsatz verschiedener Techniken wurde eine MRT-/CT-basierte Bestrahlungsplanung zur bildgestützten Hochpräzisionsstrahlentherapie in einem orthotopen Pankreastumor-Mausmodell etabliert. Moderne Bestrahlungstechniken ermöglichen eine perfekte Abdeckung des GTV bei gleichzeitiger Schonung der Risikoorgane im präklinischen Rahmen und ähneln den klinischen Bestrahlungsplänen von Patienten mit Pankreaskarzinom.

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Funding

This work was funded in part by research support for SD within the KKF (“Kommission für Klinische Forschung”), Medical Faculty of the Technical University of Munich (TUM) and by the European Union’s Seventh Program for research, technological development and demonstration under grant agreement no 263307 (SaveMe large-scale collaborative project).

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Authors and Affiliations

  1. Department of Radiation Oncology, Technical University of Munich (TUM), Klinikum rechts der Isar, Ismaninger Straße 22, 81675, Munich, Germany

    S. Dobiasch, S. Kampfer, D. Habermehl, M. N. Duma, D. Schilling, J. J. Wilkens &  S. E. Combs

  2. Institute of Innovative Radiotherapy (iRT), Department of Radiation Sciences (DRS), Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany

    S. Dobiasch, D. Habermehl, D. Schilling &  S. E. Combs

  3. Physics Department, Technical University of Munich (TUM), James-Franck-Str. 1, 85748, Garching, Germany

    S. Kampfer & J. J. Wilkens

  4. Partner Site Munich, Deutsches Konsortium für Translationale Krebsforschung (DKTK), Munich, Germany

    S. Dobiasch &  S. E. Combs

  5. Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany

    K. Felix

  6. Department of Radiology, University of Heidelberg, 69120, Heidelberg, Germany

    A. Strauss

Authors
  1. S. Dobiasch
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  2. S. Kampfer
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  3. D. Habermehl
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  4. M. N. Duma
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  5. K. Felix
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  6. A. Strauss
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  7. D. Schilling
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  8. J. J. Wilkens
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  9. S. E. Combs
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Corresponding author

Correspondence to S. E. Combs.

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Conflict of interest

S. Dobiasch, S. Kampfer, D. Habermehl, M.N. Duma, K. Felix, A. Strauss, D. Schilling, J.J. Wilkens and S.E. Combs declare that they have no competing interests.

Ethical standards

All applicable international, national and institutional guidelines for the care and use of laboratory animals were followed.

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Dobiasch, S., Kampfer, S., Habermehl, D. et al. MRI-based high-precision irradiation in an orthotopic pancreatic tumor mouse model. Strahlenther Onkol 194, 944–952 (2018). https://doi.org/10.1007/s00066-018-1326-y

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  • DOI: https://doi.org/10.1007/s00066-018-1326-y

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