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Wöchentliche oder dreiwöchentliche Cisplatin-Gaben bei der kombinierten Radiochemotherapie lokal fortgeschrittener Kopf-Hals-Tumoren?

Once-a-week versus once-every-three-weeks cisplatin application in combined chemoradiotherapy for locally advanced head and neck cancer?

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Literatur

  1. Adelstein DJ, Li Y, Adams GL et al (2003) An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J Clin Oncol 21:92–98

    Article  PubMed  Google Scholar 

  2. Bernier J, Domenge C, Ozsahin M et al (2004) Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med 350:1945–1952

    Article  CAS  PubMed  Google Scholar 

  3. Budach W, Hehr T, Budach V et al (2006) A meta-analysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma of the head and neck. BMC Cancer 6:28

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Pignon JP, le Maître A, Maillard E et al (2009) Metaanalysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients. Radiother Oncol 92:4–14

    Article  PubMed  Google Scholar 

  5. Szturz P, Wouters K, Kiyota N et al (2017) Weekly low-dose versus three-weekly high-dose cisplatin for concurrent chemoradiation in locoregionally advanced non-nasopharyngeal head and neck cancer: a systematic review and meta-analysis of aggregate data. Oncologist 22(9):1056–1066

    Article  CAS  PubMed  Google Scholar 

  6. Ghosh-Laskar S, Kalyani N, Gupta T et al (2016) Conventional radiotherapy versus concurrent chemoradiotherapy versus accelerated radiotherapy in locoregionally advanced carcinoma of head and neck: results of a prospective randomized trial. Head Neck 38:202–207

    Article  PubMed  Google Scholar 

  7. Sahoo TK, Samanta DR, Senapati SN et al (2017) A comparative study on weekly versus three weekly cisplatinum based chemoradiation in locally advanced head and neck cancers. J Clin Diagn Res 11:XC7–XC11

    PubMed  PubMed Central  Google Scholar 

  8. Uygun K, Bilici A, Karagol H et al (2009) The comparison of weekly and three-weekly cisplatin chemotherapy concurrent with radiotherapy in patients with previously untreated inoperable non-metastatic squamous cell carcinoma of the head and neck. Cancer Chemother Pharmacol 64:601–605

    Article  CAS  PubMed  Google Scholar 

  9. Tsan DL, Lin CY, Kang CJ et al (2012) The comparison between weekly and three-weekly cisplatin delivered concurrently with radiotherapy for patients with postoperative high-risk squamous cell carcinoma of the oral cavity. Radiat Oncol 7:215

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Strojan P, Vermorken JB, Beitler JJ et al (2016) Cumulative cisplatin dose in concurrent chemoradiotherapy for head and neck cancer: a systematic review. Head Neck 38:E2151–E2158

    Article  PubMed  Google Scholar 

  11. Dasari S, Tchounwou PB (2014) Cisplatin in cancer therapy: molecular mechanisms of action. Eur J Pharmacol 740:364–378

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Martina Becker-Schiebe.

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M. Becker-Schiebe und H. Christiansen geben an, dass kein Interessenkonflikt besteht.

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Originalpublikation

Noronha V, Joshi A, Patil VM, et al (2017) Once-a-week versus once-every-3-weeks cisplatin chemoradiation for locally advanced head and neck cancer: a phase III randomized noninferiority trial. J Clin Oncol: https://doi.org/10.1200/JCO.2017.74.9457

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Becker-Schiebe, M., Christiansen, H. Wöchentliche oder dreiwöchentliche Cisplatin-Gaben bei der kombinierten Radiochemotherapie lokal fortgeschrittener Kopf-Hals-Tumoren?. Strahlenther Onkol 194, 468–470 (2018). https://doi.org/10.1007/s00066-018-1283-5

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  • DOI: https://doi.org/10.1007/s00066-018-1283-5

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