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Docetaxel-induced radiation recall dermatitis

A case report and literature review

Docetaxel-induzierte Strahlen-Recall-Dermatitis

Eine Kasuistik und Review der Literatur

  • Case Study
  • Published:
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Abstract

Radiation recall dermatitis (RRD) refers to an acute inflammatory skin reaction appearing on a previously irradiated area following the systemic administration of a reaction-triggering agent. Despite various hypotheses, the pathomechanism of RRD appears complex and is still not fully understood. In addition, no clinical guidelines exist concerning whether drug treatment should be continued upon manifestation of an associated radiation recall phenomenon. We present the case of a patient with docetaxel-induced RRD, which was successfully treated with topical steroids and systemic antihistamines; re-challenge to docetaxel did result in very mild remanifestation of skin reactions.

Zusammenfassung

Die Strahlen-Recall-Dermatitis (RRD) ist eine akute entzündliche Reaktion der Haut in einem zuvor bestrahlten Areal als Reaktion auf die systemische Applikation eines triggernden Agens. Der zugrunde liegende Pathomechanismus ist bisher nicht vollständig geklärt. Ferner gibt es keine klinischen Leitlinien dazu, ob bei einem assoziierten RRD-Phänomen die medikamentöse Behandlung fortgesetzt werden sollte oder nicht. Vorgestellt wird ein Fall von Docetaxel-induzierter RRD, welche erfolgreich mit topischen Steroiden und systemischen Antihistaminika behandelt wurde. Eine erneute Docetaxel-Exposition des Patienten ging mit einer sehr milden Remanifestation der kutanen Effloreszenzen einher.

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References

  1. Burris HA, Hurtig J (2010) Radiation recall with anticancer agents. Oncologist 15(11):1227–1237

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. D’Angio GJ, Farber S, Maddock CL (1959) Potentiation of x‑ray effects by actinomycin D. Radiology 73:175–177

    Article  PubMed  Google Scholar 

  3. Camidge R, Price A (2001) Characterizing the phenomenon of radiation recall dermatitis. Radiother Oncol 59(3):237–245

    Article  CAS  PubMed  Google Scholar 

  4. Caloglu M, Yurut-Caloglu V, Cosar-Alas R (2007) An ambiguous phenomenon of radiation and drugs: recall reactions. Oncol Res Treat 30(4):209–214

    Article  Google Scholar 

  5. National Cancer Institute (2009) Common Terminology Criteria for Adverse Events, Version 4.0. http://evs.nci.nih.gov/ftp1/CTCAE/CTCAE_4.03_2010-06-14_QuickReference_5x7.pdf. Last access: 13 March 2016

    Google Scholar 

  6. Abadir R, Liebmann J (1995) Radiation reaction recall following simvastatin therapy: a new observation. Clin Oncol 7(5):325–326

    Article  CAS  Google Scholar 

  7. Boström A, Sjölin-Forsberg G, Wilking N (1999) Radiation recall – another call with tamoxifen. Acta Oncol 38(7):955–959

    Article  PubMed  Google Scholar 

  8. Acevedo F, Arriagada P, Ibañez C (2013) Radiation recall dermatitis: report of two cases. Int Canc Conf J 2(4):229–233

    Article  Google Scholar 

  9. Putnik K, Stadler P, Schäfer C, Koelbl O (2006) Enhanced radiation sensitivity and radiation recall dermatitis (RRD) after hypericin therapy – case report and review of literature. Radiat Oncol 1:32

    Article  PubMed  PubMed Central  Google Scholar 

  10. Rhee J, Kim GE, Lee CH (2014) Radiation recall dermatitis induced by tamoxifen during adjuvant breast cancer treatment. Radiat Oncol J 32(4):262–265

    Article  PubMed  PubMed Central  Google Scholar 

  11. Conen K, Mosna-Firlejczyk K, Rochlitz C (2015) Vemurafenib-induced radiation recall dermatitis: case report and review of the literature. Dermatology 230(1):1–4

    Article  CAS  PubMed  Google Scholar 

  12. Burdon J, Bell R, Sullivan J, Henderson M (1978) Adriamycin-induced recall phenomenon 15 years after radiotherapy. JAMA 239(10):931

    Article  CAS  PubMed  Google Scholar 

  13. Kodym E, Kalinska R, Ehringfeld C (2005) Frequency of radiation recall dermatitis in adult cancer patients. Onkologie 28(1):18–21

    PubMed  Google Scholar 

  14. Pardo J, Mena A, Prieto I (2013) Radiation Recall Dermatitis Development: An Observational Study in 350 Breast Cancer Patients. Int J Radiat Oncol Biol Phys 87(2):214

    Article  Google Scholar 

  15. Smith KJ, Germain M, Skelton H (2002) Histopathologic features seen with radiation recall or enhancement eruptions. J Cutan Med Surg 6(6):535–540

    Article  PubMed  Google Scholar 

  16. Giesel BU, Kutz GG, Thiel HJ (2001) Recall-Dermatitis durch Docetaxel-Reexposition nach Gehirnbestrahlung. Fallbeobachtung und Literaturübersicht. Strahlenther Onkol 177(9):487–493

    Article  CAS  PubMed  Google Scholar 

  17. Kandemir EG, Karabudak O, Maydagli A (2005) Docetaxel-induced radiation recall dermatitis. Swiss Med Wkly 135(1–2):34–35

    PubMed  Google Scholar 

  18. Morkas M, Fleming D, Hahl M (2002) Challenges in oncology. Case 2. Radiation recall associated with docetaxel. J Clin Oncol 20(3):867–869

    PubMed  Google Scholar 

  19. Piroth MD, Krempien R, Wannenmacher M, Zierhut D (2002) Radiation recall dermatitis from docetaxel. Onkologie 25(5):438–440

    CAS  PubMed  Google Scholar 

  20. Duncker-Rohr V, Freund U, Momm F (2014) Radiation recall dermatitis after docetaxel chemotherapy. Treatment by antioxidant ointment. Strahlenther Onkol 190(5):491–493

    Article  PubMed  Google Scholar 

  21. Samur M, Garipagaoglu M, Akbulut H (2001) Radiation recall effect with docetaxel: Is it a barrier for sandwich approach of radiotherapy sequencing in adjuvant breast cancer treatment? Turkish J Cancer 31(2):82-86

    Google Scholar 

  22. Culp LR, Pou AM, Jones DV (2004) A case of radiation recall mucositis associated with docetaxel. Head Neck 26(2):197–200

    Article  PubMed  Google Scholar 

  23. Camidge DR, Kunkler IH (2000) Docetaxel-induced radiation recall dermatitis and successful rechallenge without recurrence. Clin Oncol 12(4):272–273

    CAS  Google Scholar 

  24. Yeo W, Leung SF, Johnson PJ (1997) Radiation-recall dermatitis with docetaxel: establishment of a requisite radiation threshold. Eur J Cancer 33(4):698–699

    Article  CAS  PubMed  Google Scholar 

  25. Chen SS, Strauss JB, Shah AP (2009) Radiation recall reaction with docetaxel administration after accelerated partial breast irradiation with electronic brachytherapy. Brachytherapy 8(3):331–334

    Article  PubMed  Google Scholar 

  26. Borgia F, Guarneri C, Guarneri F (2005) Radiation recall dermatitis after docetaxel administration: absolute indication to replace the drug? Br J Dermatol 153(3):674–675

    Article  CAS  PubMed  Google Scholar 

  27. Mizumoto M, Harada H, Asakura H (2006) Frequency and characteristics of docetaxel-induced radiation recall phenomenon. Int J Radiat Oncol Biol Phys 66(4):1187–1191

    Article  CAS  PubMed  Google Scholar 

  28. Stelzer KJ, Griffin TW, Koh WJ (1993) Radiation recall skin toxicity with bleomycin in a patient with Kaposi sarcoma related to acquired immune deficiency syndrome. Cancer 71(4):1322–1325

    Article  CAS  PubMed  Google Scholar 

  29. Mayer EG, Poulter CA, Aristizabal SA (1976) Complications of irradiation related to apparent drug potentiation by adriamycin. Int J Radiat Oncol Biol Phys 1(11–12):1179–1188

    Article  CAS  PubMed  Google Scholar 

  30. Hellman S, Botnick LE (1977) Stem cell depletion: an explanation of the late effects of cytotoxins. Int J Radiat Oncol Biol Phys 2(1–2):181–184

    Article  CAS  PubMed  Google Scholar 

  31. Wright EG (1998) Radiation-induced genomic instability in haemopoietic cells. Int J Radiat Biol 74(6):681–687

    Article  CAS  PubMed  Google Scholar 

  32. Lorimore SA, Wright EG (2003) Radiation-induced genomic instability and bystander effects: related inflammatory-type responses to radiation-induced stress and injury? A review. Int J Radiat Biol 79(1):15–25

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

The authors would like to thank Sokratis Papaioannou MSc for his help in the preparation of the manuscript.

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Authors and Affiliations

  1. Strahlenklinik, Sana Klinikum Offenbach, Starkenburgring 66, 63069, Offenbach, Germany

    Iosif Strouthos, Nikolaos Tselis & Nikolaos Zamboglou

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  1. Iosif Strouthos
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  2. Nikolaos Tselis
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  3. Nikolaos Zamboglou
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Correspondence to Iosif Strouthos.

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Conflict of interest

I. Strouthos, N. Tselis, and N. Zamboglou state that there are no conflicts of interest.

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975 (in its most recently amended version). Informed consent was obtained from the patient included in this case study.

The authors state the accompanying manuscript is in compliance with ethical guidelines.

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Strouthos, I., Tselis, N. & Zamboglou, N. Docetaxel-induced radiation recall dermatitis. Strahlenther Onkol 192, 730–736 (2016). https://doi.org/10.1007/s00066-016-0984-x

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  • DOI: https://doi.org/10.1007/s00066-016-0984-x

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