Literatur
Ang KK, Andratschke NH, Milas L (2004) Epidermal growth factor receptor and response of head-and-neck carcinoma to therapy. Int J Radiat Oncol Biol Phys 58:959–965
Baumann M, Krause M, Hill R (2008) Exploring the role of cancer stem cells in radioresistance. Nat Rev Cancer 8:545–554
Bentley J, Diggle CP, Harnden P et al (2004) DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining. Nucleic Acids Res 32:5249–5259
Borgmann K, Haeberle D, Doerk T et al (2007) Genetic determination of chromosomal radiosensitivities in G0- and G2-phase human lymphocytes. Radiother Oncol 83:196–202
Borgmann K, Hoeller U, Nowack S et al (2008) Individual radiosensitivity measured with lymphocytes may predict the risk of acute reaction after radiotherapy. Int J Radiat Oncol Biol Phys 71:256–264
Borgmann K, Roper B, El-Awady R et al (2002) Indicators of late normal tissue response after radiotherapy for head and neck cancer: fibroblasts, lymphocytes, genetics, DNA repair, and chromosome aberrations. Radiother Oncol 64:141–152
Brammer I, Zoller M, Dikomey E (2001) Relationship between cellular radiosensitivity and DNA damage measured by comet assay in human normal, NBS and AT fibroblasts. Int J Radiat Biol 77:929–938
Budach W, Taghian A, Freeman J et al (1993) Impact of stromal sensitivity on radiation response of tumors. J Natl Cancer Inst 85:988–993
Chang-Claude J, Ambrosone CB, Lilla C et al (2009) Genetic polymorphisms in DNA repair and damage response genes and late normal tissue complications of radiotherapy for breast cancer. Br J Cancer 100:1680–1686
Dahm-Daphi J, Dikomey E (1996) Rejoining of DNA double-strand breaks in X-irradiated CHO cells studied by constant- and graded-field gel electrophoresis. Int J Radiat Biol 69:615–621
Dikomey E, Brammer I, Johansen J et al (2000) Relationship between DNA double-strand breaks, cell killing, and fibrosis studied in confluent skin fibroblasts derived from breast cancer patients. Int J Radiat Oncol Biol Phys 46:481–490
Dikomey E, Dahm-Daphi J, Brammer I et al (1998) Correlation between cellular radiosensitivity and non-repaired double-strand breaks studied in nine mammalian cell lines. Int J Radiat Biol 73:269–278
Distel L, Neubauer S, Varon R et al (2003) Fatal toxicity following radio- and chemotherapy of medulloblastoma in a child with unrecognized Nijmegen breakage syndrome. Med Pediatr Oncol 41:44–48
Distel LV, Neubauer S, Keller U et al (2006) Individual differences in chromosomal aberrations after in vitro irradiation of cells from healthy individuals, cancer and cancer susceptibility syndrome patients. Radiother Oncol 81:257–263
El-Awady RA, Dikomey E, Dahm-Daphi J (2003) Radiosensitivity of human tumour cells is correlated with the induction but not with the repair of DNA double-strand breaks. Br J Cancer 89:593–601
El-Awady RA, Mahmoud M, Saleh EM et al (2005) No correlation between radiosensitivity or double-strand break repair capacity of normal fibroblasts and acute normal tissue reaction after radiotherapy of breast cancer patients. Int J Radiat Biol 81:501–508
Goodarzi AA, Jeggo P, Lobrich M (2010) The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax. DNA Repair (Amst) 9:1273–1282
Helleday T (2011) The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings. Mol Oncol 5:387–393
Heyer WD, Ehmsen KT, Liu J (2010) Regulation of homologous recombination in eukaryotes. Annu Rev Genet 44:113–139
Hoeller U, Borgmann K, Bonacker M et al (2003) Individual radiosensitivity measured with lymphocytes may be used to predict the risk of fibrosis after radiotherapy for breast cancer. Radiother Oncol 69:137–144
Kasten-Pisula U, Menegakis A, Brammer I et al (2009) The extreme radiosensitivity of the squamous cell carcinoma SKX is due to a defect in double-strand break repair. Radiother Oncol 90:257–264
Kasten-Pisula U, Saker J, Eicheler W et al (2011) Cellular and tumor radiosensitivity is correlated to epidermal growth factor receptor protein expression level in tumors without EGFR amplification. Int J Radiat Oncol Biol Phys 80:1181–1188
Kasten-Pisula U, Tastan H, Dikomey E (2005) Huge differences in cellular radiosensitivity due to only very small variations in double-strand break repair capacity. Int J Radiat Biol 81:409–419
Keller U, Grabenbauer G, Kuechler A et al (2005) Cytogenetic instability in young patients with multiple primary cancers. Cancer Genet Cytogenet 157:25–32
Keller U, Kuechler A, Liehr T et al (2004) Impact of various parameters in detecting chromosomal aberrations by FISH to describe radiosensitivity. Strahlenther Onkol 180:289–296
Komuro Y, Watanabe T, Hosoi Y et al (2003) Prediction of tumor radiosensitivity in rectal carcinoma based on p53 and Ku70 expression. J Exp Clin Cancer Res 22:223–228
Lilla C, Ambrosone CB, Kropp S et al (2007) Predictive factors for late normal tissue complications following radiotherapy for breast cancer. Breast Cancer Res Treat 106:143–150
Lobrich M, Kuhne M, Wetzel J et al (2000) Joining of correct and incorrect DNA double-strand break ends in normal human and ataxia telangiectasia fibroblasts. Genes Chromosomes Cancer 27:59–68
Mansour WY, Schumacher S, Rosskopf R et al (2008) Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks. Nucleic Acids Res 36:4088–4098
Menegakis A, Eicheler W, Yaromina A et al (2011) Residual DNA double strand breaks in perfused but not in unperfused areas determine different radiosensitivity of tumours. Radiother Oncol 100:137–144
Mladenov E, Iliakis G (2011) Induction and repair of DNA double strand breaks: the increasing spectrum of non-homologous end joining pathways. Mutat Res 711:61–72
Muller WU, Bauch T, Stuben G et al (2001) Radiation sensitivity of lymphocytes from healthy individuals and cancer patients as measured by the comet assay. Radiat Environ Biophys 40:83–89
Nachtrab U, Oppitz U, Flentje M et al (1998) Radiation-induced micronucleus formation in human skin fibroblasts of patients showing severe and normal tissue damage after radiotherapy. Int J Radiat Biol 73:279–287
Neubauer S, Gebhart E, Schmitt G et al (1996) Is chromosome in situ suppression (CISS) hybridization suited as a predictive test for intrinsic radiosensitivity in cancer patients? Int J Oncol 8:707–712
Popanda O, Ebbeler R, Twardella D et al (2003) Radiation-induced DNA damage and repair in lymphocytes from breast cancer patients and their correlation with acute skin reactions to radiotherapy. Int J Radiat Oncol Biol Phys 55:1216–1225
Rodel F, Hoffmann J, Distel L et al (2005) Survivin as a radioresistance factor, and prognostic and therapeutic target for radiotherapy in rectal cancer. Cancer Res 65:4881–4887
Rodel F, Reichert S, Sprenger T et al (2011) The role of survivin for radiation oncology: moving beyond apoptosis inhibition. Curr Med Chem 18:191–199
Rosidi B, Wang M, Wu W et al (2008) Histone H1 functions as a stimulatory factor in backup pathways of NHEJ. Nucleic Acids Res 36:1610–1623
Rothkamm K, Kruger I, Thompson LH et al (2003) Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol Cell Biol 23:5706–5715
Rothkamm K, Lobrich M (2003) Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proc Natl Acad Sci USA 100:5057–5062
Rube CE, Dong X, Kuhne M et al (2008) DNA double-strand break rejoining in complex normal tissues. Int J Radiat Oncol Biol Phys 72:1180–1187
Rube CE, Grudzenski S, Kuhne M et al (2008) DNA double-strand break repair of blood lymphocytes and normal tissues analysed in a preclinical mouse model: implications for radiosensitivity testing. Clin Cancer Res 14:6546–6555
Rube CE, Lorat Y, Schuler N et al (2011) DNA repair in the context of chromatin: new molecular insights by the nanoscale detection of DNA repair complexes using transmission electron microscopy. DNA Repair (Amst) 10:427–437
Rudat V, Dietz A, Nollert J et al (1999) Acute and late toxicity, tumour control and intrinsic radiosensitivity of primary fibroblasts in vitro of patients with advanced head and neck cancer after concomitant boost radiochemotherapy. Radiother Oncol 53:233–245
Schirmer MA, Brockmoller J, Rave-Frank M et al (2011) A putatively functional haplotype in the gene encoding transforming growth factor beta-1 as a potential biomarker for radiosensitivity. Int J Radiat Oncol Biol Phys 79:866–874
Strasser H, Grabenbauer GG, Sprung CN et al (2007) DNA double-strand break induction and repair in irradiated lymphoblastoid, fibroblast cell lines and white blood cells from ATM, NBS and radiosensitive patients. Strahlenther Onkol 183:447–453
Twardella D, Popanda O, Helmbold I et al (2003) Personal characteristics, therapy modalities and individual DNA repair capacity as predictive factors of acute skin toxicity in an unselected cohort of breast cancer patients receiving radiotherapy. Radiother Oncol 69:145–153
Wang H, Perrault AR, Takeda Y et al (2003) Biochemical evidence for Ku-independent backup pathways of NHEJ. Nucleic Acids Res 31:5377–5388
West CM (1995) Invited review: intrinsic radiosensitivity as a predictor of patient response to radiotherapy. Br J Radiol 68:827–837
Yaromina A, Krause M, Thames H et al (2007) Pre-treatment number of clonogenic cells and their radiosensitivity are major determinants of local tumour control after fractionated irradiation. Radiother Oncol 83:304–310
Zschenker O, Raabe A, Boeckelmann IK et al (2010) Association of single nucleotide polymorphisms in ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with clinical and cellular radiosensitivity. Radiother Oncol 97:26–32
Interessenkonflikt
Der korrespondierende Autor gibt für sich und seine Koautoren an, dass kein Interessenkonflikt besteht.
Author information
Authors and Affiliations
Corresponding author
Additional information
E. Dikomey, J. Dahm-Daphi und L. Distel haben gleichermaßen zur Arbeit beigetragen.
Rights and permissions
About this article
Cite this article
Dikomey, E., Dahm-Daphi, J. & Distel, L. Prädiktion von Normal- und Tumorreaktion nach Strahlentherapie. Strahlenther Onkol 188 (Suppl 3), 304–307 (2012). https://doi.org/10.1007/s00066-012-0204-2
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00066-012-0204-2