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Correlation of Pretreatment Polarographically Measured Oxygen Pressures with Quantified Contrast-Enhanced Power Doppler Ultrasonography in Spontaneous Canine Tumors and their Impact on Outcome After Radiation Therapy

Korrelation des polarographisch gemessenen Sauerstoffdrucks mit quantifiziertem, kontrastverstärktem Power-Doppler-Ultraschall bei spontanen kaninen Tumoren und deren Einfluss auf das Tumorverhalten nach Strahlentherapie

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Purpose:

To evaluate the use of noninvasive quantified contrast-enhanced power Doppler ultrasonography as a surrogate in the estimation of tumor hypoxia measured by invasive pO2 histography in canine tumors.

Material and Methods:

Data of pretreatment tumor oxygenation status, tumor vascularity and blood volume, and tumor response after radiation therapy was collected in 48 spontaneous malignant oral tumors (Table 1). Tumor oxygenation status was correlated to vascularity and blood volume, and influences on outcome after treatment were analyzed.

Results:

Although vascularity and blood volume correlated moderately with median pO2 (r = 0.51 and 0.61; p = 0.001 and < 0.0001) and percentage of pO2 readings ≤ 2.5, 5, and 10 mmHg (r = –0.37 to –0.42; p < 0.01–0.03) for all tumors, they did not correlate within the different histology groups (p = 0.06–0.9). For all tumors, pretreatment oxygenation status, vascularity and blood volume were not found to be of prognostic value (Tables 2 and 3).

Conclusion:

These analyses show that quantified contrast-enhanced power Doppler ultrasonography does not represent a noninvasive indirect method to assess tumor hypoxia measured by invasive pO2 histography. Both technologies were nonprognostic indicators in spontaneous malignant canine oral tumors.

Ziel:

Untersuchung des nichtinvasiven quantifizierten, kontrastverstarkten Power-Doppler-Ultraschalls als alternative Methode bei der Einschatzung der Tumorhypoxie, die in spontanen Tumoren beim Hund mittels invasiver pO2-Histographie gemessen wurde.

Material und Methodik:

Oxygenierungsstatus, Gefasdichte und Blutvolumen vor der Behandlung sowie das Tumorverhalten nach Strahlentherapie wurden bei 48 Hunden mit spontanen malignen Tumoren der Maulhohle untersucht (Tabelle 1). Der Oxygenierungsstatus wurde zur Gefasdichte und zum Blutvolumen korreliert, und Faktoren, die die Tumorantwort nach Strahlentherapie beeinflussen konnen, wurden analysiert.

Ergebnisse:

Obwohl die Gefasdichte sowie das Blutvolumen moderat mit dem Zentralwert (medianer pO2 [r = 0,51 und 0,61; p = 0,001 und < 0,0001]) und der prozentualen Verteilung der pO2-Messwerte ≤ 2,5, 5 und 10 mmHg (r = –0,37 bis –0,42; p < 0,01–0,03) fur alle Tumoren korrelierte, verlor sich diese Korrelation innerhalb der einzelnen histologischen Gruppen (p = 0,06–0,9). Uber alle Tumortypen gesehen, waren Oxygenierungsstatus, Gefasdichte und Blutvolumen, gemessen vor der Strahlentherapie, nicht von prognostischem Wert (Tabellen 2 und 3).

Schlussfolgerung:

Diese Untersuchung zeigt, dass der kontrastverstarkte Power-Doppler-Ultraschall die invasive pO2-Histographie nicht ersetzt und beide Methoden keine prognostischen Indikatoren bei spontanen Tumoren der Maulhohle des Hundes darstellen.

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Authors and Affiliations

  1. Section of Radiooncology, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland

    Carla Rohrer Bley, Dagmar Laluhova & Barbara Kaser-Hotz

  2. Institute for Social and Preventive Medicine, Medical Faculty, University of Zurich, Zurich, Switzerland

    Malgorzata Roos

  3. Section Imaging Diagnostics, Vetsuisse Faculty, University of Zurich, Zurich, Switzerland

    Barbara Kaser-Hotz & Stefanie Ohlerth

  4. Section of Radiooncology, Vetsuisse Faculty, University of Zurich, Winterthurerstraße 260, 8057, Zürich, Switzerland

    Carla Rohrer Bley

Authors
  1. Carla Rohrer Bley
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  2. Dagmar Laluhova
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  3. Malgorzata Roos
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  4. Barbara Kaser-Hotz
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  5. Stefanie Ohlerth
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Corresponding author

Correspondence to Carla Rohrer Bley.

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Both authors contributed equally to the study.

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Rohrer Bley, C., Laluhova, D., Roos, M. et al. Correlation of Pretreatment Polarographically Measured Oxygen Pressures with Quantified Contrast-Enhanced Power Doppler Ultrasonography in Spontaneous Canine Tumors and their Impact on Outcome After Radiation Therapy. Strahlenther Onkol 185, 756–762 (2009). https://doi.org/10.1007/s00066-009-1988-6

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  • DOI: https://doi.org/10.1007/s00066-009-1988-6

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