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„Intravasal trocken – Gewebe voll“: interstitielles Ödem und Volumenmanagement in der Intensivmedizin

“Intravascular space contracted—tissue space expanded”: interstitial edema and fluid management in intensive care medicine


In der zweiten Phase der Schocktherapie liegt regelmäßig eine Flüssigkeitsüberladung mit Ödemen vor, die nicht nur die Haut und Bindegewebe betreffen, sondern auch Organfunktionen u. a. der Nieren, Lunge und Leber beeinträchtigen. Neue Erkenntnisse zum revidierten Starling-Prinzip und der endothelialen Glykokalyx haben Implikationen für eine adäquate Flüssigkeitstherapie in der zweiten Phase der Sepsis. Die Diagnose einer Flüssigkeitsüberladung sowie eine sachgerechte Diuretika- oder Ultrafiltrationstherapie sind Schwerpunkte eines „Late goal-directed fluid removal“-Managements.


In the second phase of shock therapy, we regularly find fluid overload with edema in our patients, which not only involves the skin and interstitial tissue but can also impair kidney, liver and pulmonary function. Revision of the Starling principle and new insights into physiology of the endothelial glycocalyx have important implications for fluid therapy in intensive care medicine. Determination of fluid overload and an appropriate therapy with either diuretics or ultrafiltration are the focus of “late goal-directed fluid removal” management.

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Correspondence to Gunnar Schley or Carsten Willam.

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G. Schley und C. Willam geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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Stefan Kluge, Hamburg

Carsten Willam, Erlangen

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Schley, G., Willam, C. „Intravasal trocken – Gewebe voll“: interstitielles Ödem und Volumenmanagement in der Intensivmedizin. Med Klin Intensivmed Notfmed 116, 665–671 (2021).

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  • Flüssigkeitstherapie
  • Intensivmedizin
  • Schock
  • Sepsis
  • Endothelzellen


  • Fluid therapy
  • Critical care
  • Shock
  • Sepsis
  • Endothelial cells