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Fallstricke bei der Resistenzbestimmung

Pitfalls in determining resistance

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Zusammenfassung

Häufig ist die Auswahl einer optimalen Antibiotikatherapie für die Morbidität und Letalität einer Infektionskrankheit entscheidend. Ein verlässliches Antibiogramm stellt eine wesentliche Grundlage zur Therapieoptimierung dar. Bei bedrohlichen Infektionen sollten Werte der minimalen Hemmkonzentration ermittelt werden, anhand derer im Zusammenhang mit pharmakokinetischen Kenntnissen über die jeweiligen antimikrobiellen Chemotherapeutika eine rationale Therapieauswahl im Einzelfall möglich wird. Soweit kategorisierte Testergebnisse (sensibel, intermediär, resistent: S-I-R) übermittelt werden, sollten diese nach den Vorgaben des European Committee on Antimicrobial Susceptibility Testing (EUCAST) beurteilt sein, um Therapieversagen nach Möglichkeit zu vermeiden.

Abstract

Selection of the optimal antimicrobial therapy is often crucial for the morbidity and mortality associated with an infection. A reliable antibiogram provides the basis for antibiotic therapy optimization. In case of life-threatening infections, minimal inhibitory concentration values should be available so that, in conjunction with knowledge of the pharmacokinetic properties of the respective antibiotics, a rational selection addressing the individual case is feasible. If only categorized results (susceptible, intermediate, resistant: S-I-R) are available, they should be established according to European Committee on Antimicrobial Susceptibility Testing (EUCAST) guidelines in order to avoid therapeutic failures.

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Literatur

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Einhaltung ethischer Richtlinien

Interessenkonflikt. A.C. Rodloff gibt an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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  1. Institut für Medizinische Mikrobiologie und Infektionsepidemiologie, Liebigstr. 21, 04103, Leipzig, Deutschland

    A.C. Rodloff

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Rodloff, A. Fallstricke bei der Resistenzbestimmung. Med Klin Intensivmed Notfmed 109, 182–186 (2014). https://doi.org/10.1007/s00063-013-0311-6

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