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Thrombingenerierung bei kritischer Erkrankung

Thrombin generation in critical illnesses

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Zusammenfassung

Die Hämostase ist ein wichtiger Bestandteil der Wirtsabwehr und Wundheilung. Die Interaktion zwischen Hämostase und Inflammation ist erst in den letzten Jahrzehnten ins Zentrum der Forschung gerückt. Im Mittelpunkt dieser Untersuchungen steht das Thrombin, das als das zentrale Enzym des Hämostasesystems gilt. Immunmodulatorische Therapiestrategien, wie die supraphysiologischen Gaben von Antithrombin und aktiviertem Protein C bei Sepsis, basierten auf den Grundlagen der wissenschaftlichen Untersuchungen über Thrombingenerierung und deren Rolle in der inflammatorischen Reaktion. Die komplexe Funktion des Thrombins ist allerdings noch nicht vollständig geklärt worden.

Abstract

Hemostasis is an important component of host defense and wound healing. During the last few decades, the interaction between hemostasis and inflammation has moved into the center of research. Thrombin, which is considered the central enzyme of the hemostatic system, plays a key role in these investigations. Immune modulatory treatment strategies, such as the supraphysiological doses of antithrombin and activated protein C in sepsis, were based on scientific investigations of thrombin generation and its role in inflammatory reactions. However, the complex function of thrombin has not yet been fully elucidated.

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Interessenkonflikt

Der Erstautor erhielt von CSL Behring eine finanzielle Unterstützung für ein unabhängiges wissenschaftliches Projekt.

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  1. Interdisziplinäre Internistische Intensivmedizin, Universitätsklinikum Leipzig AöR, Liebigstr. 20, 04103, Leipzig, Deutschland

    S. Petros & R. Siegemund

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  1. S. Petros
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  2. R. Siegemund
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Correspondence to S. Petros.

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Petros, S., Siegemund, R. Thrombingenerierung bei kritischer Erkrankung. Med Klin 106, 166–170 (2011). https://doi.org/10.1007/s00063-011-0013-x

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  • DOI: https://doi.org/10.1007/s00063-011-0013-x

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