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Chronische Hepatitis B mit einer unerwarteten Koinfektion

Chronic Hepatitis B with an Unexpected Coinfection

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Zusammenfassung

Hintergrund:

Weltweit sind 350 Millionen Menschen mit dem Hepatitis- B-Virus (HV) infiziert, insbesondere in tropischen Regionen. Die Schistosomiasis (Bilharziose) ist eine Tropenerkrankung mit 200 Millionen Infizierten, sodass eine hohe Rate an Koinfektonen zu erwarten ist.

Fallbeschreibung:

Ein 34-jähriger, afrikanischer Patient wurde mit einer bekannten Hepatitis B/D-Koinfektion zur Beurteilung einer antiviralen Therapie in unsere Klinik überwiesen.

Ergebnisse:

Überraschenderweise zeigte sich neben den viral induzierten Veränderungen innerhalb der Leberbiopsie ein Granulom mit einem Schistosomen- Ei. In den hierauf veranlassten Stuhluntersuchungen konnte der Parasit als Schistosoma mansoni identifiziert werden. Vor Einleitung einer anti viralen Therapie wurde eine antischistosomale Therapie mit Praziquantel durchgeführt.

Schlussfolgerung:

Patienten, die aus tropischen Ländern stammen und an einer chronisch viralen Hepatitis leiden, können weitere Koinfektionen aufweisen, die in der täglichen klinischen Routine leicht übersehen werden. Bei Patienten aus Bilharziose-Endemiegebieten und begründetem Verdacht auf eine parasitäre Koinfektion sollte eine tropenmedizinische Abklärung erfolgen.

Abstract

Background:

Schistosomiasis and hepatitis B are both tropical diseases with more than 200 and 350 million people infected worldwide respectively, but are rare in western countries. Worldwide a high rate of coinfections can be expected.

Case Report:

A 34-year-old African patient was referred to our clinic with known hepatitis B/D-coinfection for evaluation of antiviral treatment.

Results:

Surprisingly, liver biopsy showed a granuloma with the egg of Schistosoma in addition to virus induced alterations. Subsequent examination of the stool allowed to classify the parasite as Schistosoma mansoni. Thus, before initiation of an antiviral treatment, an antischistosomal therapy with praziquantel leading to elimination of schistosomiasis was started.

Conclusion:

Patients from tropical countries suffering from chronic viral hepatitis may present with additional coinfections which can be earily overlooked in daily clinical routine. Screening of African patients from endemic areas for schistosomiasis should include examinations for tropical diseases by specialists.

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Correspondence to Andreas Erhardt MD.

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Göbel, T., Erhardt, A., Richter, J. et al. Chronische Hepatitis B mit einer unerwarteten Koinfektion. Med Klin 105, 827–830 (2010). https://doi.org/10.1007/s00063-010-1141-4

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  • DOI: https://doi.org/10.1007/s00063-010-1141-4

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