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Aggravation of Enlarged Perivascular Spaces in the Centrum Semiovale of Patients with Aneurysmal Subarachnoid Hemorrhage

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Abstract

Purpose

This study aimed to investigate whether enlarged perivascular spaces (ePVS) within the basal ganglia (BG) or centrum semiovale (CSO) aggravate in patients with aneurysmal subarachnoid hemorrhage (aSAH).

Methods

We retrospectively evaluated 139 patients who had undergone brain magnetic resonance imaging (MRI) within 1 month of aSAH occurrence from January 2007 to November 2018. Follow-up brain MRI of 99 patients were available. We scored ePVS in the BG and CSO on a score of 0–4 (0 = no ePVS, 4 ≥ 40 ePVS) on initial and follow-up T2-weighted MRI. Aggravation of ePVS was defined as an ePVS score increase of ≥ 1 on follow-up MRI compared to the initial score. We compared the characteristics between patients with and without aggravation of ePVS and investigated associated variables using logistic regression.

Results

Aggravation of ePVS in the CSO and BG was noted in 31 (31.3%) and 6 (6.1%) patients, respectively. After adjusting for age, sex, and the MRI follow-up period, aggravation of ePVS in the CSO was independently associated with a high Fisher grade (p = 0.007) and high burden of initial ePVS in the CSO (p = 0.049).

Conclusion

Aggravation of ePVS, particularly those in the CSO, had occurred in the long-term follow-up of aSAH patients. This was independently associated with a high burden of aSAH. The amount of subarachnoid blood might have aggravated the drainage of interstitial fluid through glymphatic dysfunction.

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Funding

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIT) (No. NRF-2020R1C1C1005724).

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Authors and Affiliations

  1. Department of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Eonjuro 63-gil 20, Gangnam-gu, Seoul, Korea (Republic of)

    Jina Kim M.D., Bio Joo M.D., Jin Woo Kim M.D., Mina Park M.D., Ph.D., Sung Jun Ahn M.D., Ph.D. & Sang Hyun Suh M.D., Ph.D.

  2. Department of Neurosurgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Eonjuro 63-gil 20, Gangnam-gu, Seoul, Korea (Republic of)

    Sang Kyu Park M.D., Ph.D.

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  1. Jina Kim M.D.
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Correspondence to Mina Park M.D., Ph.D..

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Conflict of interest

J. Kim, B. Joo, J.W. Kim, M. Park, S.J. Ahn, S.K. Park and S.H. Suh declare that they have no competing interests.

Ethical standards

For this article no studies with human participants or animals were performed by any of the authors. All studies performed were in accordance with the ethical standards indicated in each case. The Institutional Review Board of the Gangnam Severance Hospital approved this study and waived the written consent.

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Kim, J., Joo, B., Kim, J.W. et al. Aggravation of Enlarged Perivascular Spaces in the Centrum Semiovale of Patients with Aneurysmal Subarachnoid Hemorrhage. Clin Neuroradiol 32, 79–87 (2022). https://doi.org/10.1007/s00062-021-01098-y

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