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Long-term Angiographic Results of the Low-profile Acandis Acclino Stent for Treatment of Intracranial Aneurysms

A Multicenter Study

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Abstract

Purpose

The low-profile Acandis Acclino is a self-expandable nitinol microstent for stent-assisted coiling of intracranial aneurysms. This article reports long-term clinical and angiographic outcome in a multicenter setting.

Methods

In this study 98 consecutive patients (mean age 55.4 ± 13.5 years) were treated with the Acclino for 98 aneurysms (28 unruptured, 20 recurrent, 50 ruptured) at 3 German tertiary care centers within a 6-year period. The technical success, complications, clinical outcome and angiographic results were retrospectively analyzed.

Results

The technical success rate was 100% with immediate complete occlusion achieved in 89.8% of the patients. Among 65 patients (66.3%) available for a 6‑month follow-up, complete and near-complete occlusion rates were 92.3% and 98.5%, respectively. In 38 patients (38.8%) with long-term follow-up (mean: 21 months), complete and near-complete occlusion were achieved in 81.2% and 89.5%, respectively. Aneurysm recurrence between mid-term and long-term follow-up was observed in 14.3%. The retreatment rate was 11.3%. There were three thromboembolic events (3.1%), of which one resulted in ischemic stroke (1.0%). For unruptured aneurysms, the procedural and device-related morbidity rates were 2.1% and 0%, respectively.

Conclusion

In the present study, the Acclino was associated with a low risk of thromboembolic complications and high aneurysm occlusion rates at long-term follow-up. Due to incomplete angiographic follow-up in this series, prospective studies will be necessary to confirm the results.

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Funding

This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Neuroradiology, University Hospital of Cologne, Kerpener Straße 67, 50937, Cologne, Germany

    Lukas Goertz, Jan Borggrefe, Marc Schlamann, Kai Laukamp & Christoph Kabbasch

  2. Faculty of Medicine and University Hospital, Center for Neurosurgery, University of Cologne, Kerpener Straße 67, 50937, Cologne, Germany

    Lukas Goertz & Boris Krischek

  3. Department of Neuroradiology, University Hospital of Duesseldorf, Moorenstraße 5, 40225, Duesseldorf, Germany

    Michael A. Smyk & Bernd Turowski

  4. Department of Neuroradiology, University Hospital of Aachen, Pauwelsstrase 30, 52074, Aachen, Germany

    Anastasios Mpotsaris

  5. Department of Neuroradiology, LMU University Hospital of Munich, Marchioninistraße 15, 81377, Munich, Germany

    Franziska Dorn & Thomas Liebig

Authors
  1. Lukas Goertz
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  2. Michael A. Smyk
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  3. Anastasios Mpotsaris
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  4. Jan Borggrefe
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  5. Franziska Dorn
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  6. Thomas Liebig
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  7. Marc Schlamann
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  8. Kai Laukamp
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  9. Boris Krischek
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  10. Bernd Turowski
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  11. Christoph Kabbasch
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Corresponding author

Correspondence to Lukas Goertz.

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Conflict of Interest

C. Kabbasch and F. Dorn serve as consultants for Acandis GmbH (Pforzheim, Germany). T. Liebig serves as proctor for MicroVention Inc./Sequent Medical (Aliso Viejo, CA, USA). L. Goertz, M.A. Smyk, A. Mpotsaris, J. Borggrefe, M. Schlamann, K. Laukamp, B. Krischek and B. Turowski declare that they have no competing interests.

Ethical standards

According to institutional guidelines, no ethics committee approval was required for this retrospective observational study. The manuscript does not contain any details that might disclose the identity of the patients.

Additional information

L. Goertz and Michael A. Smyk contributed equally.

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Goertz, L., Smyk, M.A., Mpotsaris, A. et al. Long-term Angiographic Results of the Low-profile Acandis Acclino Stent for Treatment of Intracranial Aneurysms. Clin Neuroradiol 30, 827–834 (2020). https://doi.org/10.1007/s00062-019-00847-4

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  • DOI: https://doi.org/10.1007/s00062-019-00847-4

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