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Vessel Wall and Lumen Features in North American Moyamoya Patients

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Abstract

Purpose

To apply intracranial vessel wall imaging (VWI) to determine changes in vessel wall characteristics between North American moyamoya patients and controls, as well as with standard clinical measures of moyamoya disease severity.

Methods

North American moyamoya patients and controls underwent intracranial 3.0 T VWI. Moyamoya patients also underwent digital subtraction angiography (DSA), from which modified Suzuki scores (mSS) were calculated. Lumen and outer vessel wall diameters of the supraclinoid internal carotid arteries (ICAs) and basilar artery on VWI were measured by two readers from which wall thickness was calculated. Controls and moyamoya patients were compared in logistic regression using disease category (moyamoya or none) as the dependent variable and wall thickness, age, gender, and side as the explanatory variables (significance: two-sided p < 0.05). In moyamoya patients, regression was performed with mSS as the dependent variable and wall thickness, age, gender, and side as the explanatory variables. Analyses were repeated for each lumen diameter and outer vessel wall diameter in place of wall thickness.

Results

Patients with moyamoya (n = 23, gender = 3/20 male/female; age = 43 ± 12 years) and controls (n = 23, gender = 3/20 male/female, age = 43 ± 13 years) were included. Moyamoya patients showed a significantly smaller ICA lumen and outer vessel wall diameter compared to controls (p < 0.05) but no significant change in vessel wall thickness. Similarly, ICA lumen and outer vessel wall diameters decreased with increasing mSS (p < 0.05).

Conclusion

Findings suggest decreased ICA lumen and outer vessel wall diameters, but no significant difference in wall thickness, between patients and controls. Lumen and outer vessel wall diameters also decreased with disease severity.

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Funding

National Institute of Health/National Institute of Neurological Disorders and Stroke 1R01NS07882801A1. National Institute of Health/National Institute of Neurological Disorders and Stroke 1R01NS097763. American Heart Association National affiliate 14CSA20380466.

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Authors and Affiliations

  1. Department of Radiology, Mayo Clinic, 200 First St SW, 55905, Rochester, MN, USA

    Petrice M. Cogswell

  2. Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA

    Sarah K. Lants, L. Taylor Davis, Meher R. Juttukonda, Matthew R. Fusco & Manus J. Donahue

  3. Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA

    Matthew R. Fusco

Authors
  1. Petrice M. Cogswell
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  2. Sarah K. Lants
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  3. L. Taylor Davis
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  4. Meher R. Juttukonda
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  5. Matthew R. Fusco
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  6. Manus J. Donahue
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Corresponding author

Correspondence to Petrice M. Cogswell.

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Conflict of interest

P.M. Cogswell, S.K. Lants, L. T. Davis, M.R. Juttukonda and M.R. Fusco declare that they have no competing interests. M.J. Donahue receives research-related support from Philips North America and is the CEO of Biosight LLC, which provides healthcare technology consulting services. This agreement has been approved by Vanderbilt University Medical Center in accordance with its conflict of interest policy.

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Cogswell, P.M., Lants, S.K., Davis, L.T. et al. Vessel Wall and Lumen Features in North American Moyamoya Patients. Clin Neuroradiol 30, 545–552 (2020). https://doi.org/10.1007/s00062-019-00819-8

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  • DOI: https://doi.org/10.1007/s00062-019-00819-8

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