Isolated Intracranial Myeloid Sarcoma at Age 6 Months with Metastases

Case Report and Review of the Literature
  • Jianbin Zhu
  • Sujan Thapa
  • Xianlong Wang
  • Chunxiu Jiang
  • Yaoming Qu
  • Zhibo WenEmail author


Myeloid sarcoma (MS) is a neoplasm formed by the infiltration of protogranulocytes or immature myeloid cells into organs and tissues other than bone marrow [1]. It can be associated with acute myeloid leukemia (AML) or chronic myeloid leukemia (CML) and other myeloproliferative disorders at the same time or before or after [2]. Isolated MS is defined as the disease without evidence of AML in bone marrow biopsy and failure to develop into AML within 30 days after the diagnosis of MS, which has an incidence of approximately 2 out of 1 million adults and 0.7 out of 1 million children; however, in infants it is even rarer [3, 4]. An MS can invade any anatomical site [1], the occurrence of MS in the central nervous system (CNS) is rare [5] and isolated primary intracranial MS should be carefully considered. This article presents a unique case of isolated intracranial MS at in a 6‑month-old patient with extensive brain metastases to highlight the unusual clinical and imaging...


Conflict of interest

J. Zhu, S. Thapa, X. Wang, C. Jiang, Y. Qu and Z. Wen declare that they have no competing interests.


  1. 1.
    Yilmaz AF, Saydam G, Sahin F, Baran Y. Granulocytic sarcoma: a systematic review. Am J Blood Res. 2013;3:265–70.Google Scholar
  2. 2.
    Rosenberg C, Finger PT, Furlan L, Iacob CE. Bilateral epibulbar granulocytic sarcomas: a case of an 8‑year-old girl with acute myeloid leukaemia. Graefes Arch Clin Exp Ophthalmol. 2007;245:170–2.CrossRefGoogle Scholar
  3. 3.
    Movassaghian M, Brunner AM, Blonquist TM, Sadrzadeh H, Bhatia A, Perry AM, Attar EC, Amrein PC, Ballen KK, Neuberg DS, Fathi AT. Presentation and outcomes among patients with isolated myeloid sarcoma: a surveillance, epidemiology, and end results database analysis. Leuk Lymphoma. 2015;56:1698–703.CrossRefGoogle Scholar
  4. 4.
    Antic D, Elezovic I, Milic N, Suvajdzic N, Vidovic A, Perunicic M, Djunic I, Mitrovic M, Tomin D. Is there a “gold” standard treatment for patients with isolated myeloid sarcoma? Biomed Pharmacother. 2013;67:72–7.CrossRefGoogle Scholar
  5. 5.
    Oestgaard LSG, Sengeloev H, Holm MS, Johnsen HE, Severinsen MT, Kjeldsen E, Bergmann OJ, Friis LS, Jensen MK, Nielsen OJ, Kjeldsen L, Norgaard JM. Extramedullary leukemia and myeloid sarcoma in AML: results from a population-based registry study of 2261 patients. Blood. 2011;118:2003.Google Scholar
  6. 6.
    Qian J, Cui QU, Liu Y, Li X, Sun X, Zhu H, Wang C. Isolated primary intracranial myeloid sarcoma with neuromeningeal infiltration: a case report. Oncol Lett. 2015;9:1647–50.CrossRefGoogle Scholar
  7. 7.
    Cervantes GM, Cayci Z. Intracranial CNS manifestations of myeloid sarcoma in patients with acute myeloid leukemia: review of the literature and three case reports from the author’s institution. J Clin Med. 2015;4:1102–12.CrossRefGoogle Scholar
  8. 8.
    Psiachou-Leonard E, Paterakis G, Stefanaki K, Mikraki-Christou V, Haidas S. Cerebellar granulocytic sarcoma in an infant with CD56+ acute monoblastic leukemia. Leuk Res. 2001;25:1019–21.CrossRefGoogle Scholar
  9. 9.
    Olar A, Lapadat R, Davidson CJ, Stein TD, Dahiya S, Perry A, Gheorghe G. Central nervous system involvement by myeloid sarcoma: a report of 12 cases and review of the literature. Clin Neuropathol. 2016;35:314–25.CrossRefGoogle Scholar
  10. 10.
    Bain EE, Rothman I, Lin L. De novo myeloid sarcoma in a 4-month-old infant: a case report and review of the literature. J Cutan Pathol. 2013;40:321–5.CrossRefGoogle Scholar
  11. 11.
    Suzer T, Colakoglu N, Cirak B, Keskin A, Coskun E, Tahta K. Intracerebellar granulocytic sarcoma complicating acute myelogenous leukemia: a case report and review of the literature. J Clin Neurosci. 2004;11:914–7.CrossRefGoogle Scholar
  12. 12.
    Siraj F, Kaur M, Dalal V, Khanna A, Khan AA. Myeloid sarcoma: a report of four cases at unusual sites. Ger Med Sci. 2017;15:Doc3. Scholar
  13. 13.
    Nikolic B, Feigenbaum F, Abbara S, Martuza RL, Schellinger D. CT changes of an intracranial granulocytic sarcoma on short-term follow-up. AJR Am J Roentgenol. 2003;180:78–80.CrossRefGoogle Scholar
  14. 14.
    Choi EK, Ha HK, Park SH, Lee SJ, Jung SE, Kim KW, Lee SS. Granulocytic sarcoma of bowel: CT findings. Radiology. 2007;243:752.CrossRefGoogle Scholar
  15. 15.
    Hakyemez B, Yildirim N, Taskapilioglu O, Erdogan C, Aker S, Yilmazlar S, Parlak M. Intracranial myeloid sarcoma: conventional and advanced MRI findings. Br J Radiol. 2007;80:109–12.CrossRefGoogle Scholar
  16. 16.
    Pui MH, Fletcher BD, Langston JW. Granulocytic sarcoma in childhood leukemia: imaging features. Radiology. 1994;190:698–702.CrossRefGoogle Scholar
  17. 17.
    Avni B, Koren-Michowitz M. Myeloid sarcoma: current approach and therapeutic options. Ther Adv Hematol. 2011;2:309.CrossRefGoogle Scholar
  18. 18.
    Wang HQ, Li J. Clinicopathological features of myeloid sarcoma: report of 39 cases and literature review. Pathol Res Pract. 2016;212:817–24.CrossRefGoogle Scholar
  19. 19.
    Tsimberidou AM, Kantarjian HM, Wen S, Keating MJ, O’Brien S, Brandt M et al. Myeloid sarcoma is associated with superior event-free survival and overall survival compared with acute myeloid leukemia. Cancer. 2010;113:1370–8.CrossRefGoogle Scholar
  20. 20.
    Pileri SA, Ascani S, Cox MC, Campidelli C, Bacci F, Piccioli M, Piccaluga PP, Agostinelli C, Asioli S, Novero D, Bisceglia M, Ponzoni M, Gentile A, Rinaldi P, Franco V, Vincelli D, Pileri A Jr, Gasbarra R, Falini B, Zinzani PL, Baccarani M. Myeloid sarcoma: clinico-pathologic, phenotypic and cytogenetic analysis of 92 adult patients. Leukemia. 2007;21:340–50.CrossRefGoogle Scholar
  21. 21.
    Imrie KR, Kovacs MJ, Selby D, Lipton J, Patterson BJ, Pantalony D, Poldre P, Ngan BY, Keating A. Isolated chloroma: the effect of early antileukemic therapy. Ann Intern Med. 1995;123:351-3.CrossRefGoogle Scholar
  22. 22.
    Antic D, Verstovsek S, Elezovic I, Grujicic D, Gotic M, Bila J, Perunicic M, Jakovic L. Spinal epidural granulocytic sarcoma in non-leukemic patient. Int J Hematol. 2009;89:95–7.CrossRefGoogle Scholar
  23. 23.
    Taga T, Imamura T, Nakashima K, Maeda N, Watanabe A, Miyajima Y, Sakaguchi S, Sano H, Hasegawa D, Kawasaki H, Adachi S, Takagi M, Koh K, Manabe A, Taki T, Ishida Y. Clinical characteristics of pediatric patients with myeloid sarcoma without bone marrow involvement in Japan. Int J Hematol. 2018;108:438–42.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  • Jianbin Zhu
    • 1
  • Sujan Thapa
    • 1
  • Xianlong Wang
    • 1
  • Chunxiu Jiang
    • 1
  • Yaoming Qu
    • 1
  • Zhibo Wen
    • 1
    Email author
  1. 1.Department of Radiology, Zhujiang HospitalSouthern Medical UniversityGuangzhouChina

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