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Intravascular large B‑cell lymphoma (IVLBCL) is a rare extranodal non-Hodgkin’s lymphoma characterized by growth of neoplastic cells in lumina of small vessels, with a propensity to manifest in the central nervous system. Clinical presentation is often a puzzling array of symptoms caused by small vessel occlusions, with or without constitutional symptoms. Magnetic resonance imaging (MRI) findings are diverse and can be negative in half of the cases . We present here a biopsy proven IVLBCL case where a spontaneous radiographic regression was captured. We detailed its unique clinical and radiographic evolution. Given IVLBCL’s dynamic clinical course, recognition of such dynamic MRI patterns can facilitate earlier suspicion for this rare disease.
A 74-year-old man with no significant past medical history was seen in neuro-oncological consultation for 2 years of episodic right hemiparesis, speech difficulties and confusion. The sentinel event was a short episode...
Conflict of interest
A.M. Chan, A. Huttner and J. Baehring declare that they have no competing interests.
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