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High Resolution Imaging of Viscoelastic Properties of Intracranial Tumours by Multi-Frequency Magnetic Resonance Elastography

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Abstract

Purpose

In recent years Magnetic Resonance Elastography (MRE) emerged into a clinically applicable imaging technique. It has been shown that MRE is capable of measuring global changes of the viscoelastic properties of cerebral tissue. The purpose of our study was to evaluate a spatially resolved three-dimensional multi-frequent MRE (3DMMRE) for assessment of the viscoelastic properties of intracranial tumours.

Methods

A total of 27 patients (63±13 years) were included. All examinations were performed on a 3.0 T scanner, using a modified phase-contrast echo planar imaging sequence. We used 7 vibration frequencies in the low acoustic range with a temporal resolution of 8 dynamics per wave cycle. Post-processing included multi-frequency dual elasto-visco (MDEV) inversion to generate high-resolution maps of the magnitude |G*| and the phase angle φ of the complex valued shear modulus.

Results

The tumour entities included in this study were: glioblastoma (n = 11), anaplastic astrocytoma (n = 3), meningioma (n = 7), cerebral metastasis (n = 5) and intracerebral abscess formation (n = 1). Primary brain tumours and cerebral metastases were not distinguishable in terms of |G*| and φ. Glioblastoma presented the largest range of |G*| values and a trend was delineable that glioblastoma were slightly softer than WHO grade III tumours. In terms of φ, meningiomas were clearly distinguishable from all other entities.

Conclusions

In this pilot study, while analysing the viscoelastic constants of various intracranial tumour entities with an improved spatial resolution, it was possible to characterize intracranial tumours by their mechanical properties. We were able to clearly delineate meningiomas from intraaxial tumours, while for the latter group an overlap remains in viscoelastic terms.

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Conflict of Interest

All authors declare that there is no conflict of interest.

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Authors and Affiliations

  1. Department of Neuroradiology, University of Leipzig, Liebigstr. 20, 04103, Leipzig, Germany

    M. Reiss-Zimmermann MD, D. Fritzsch MD & K.-T. Hoffmann MD

  2. Department of Radiology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany

    K.-J. Streitberger MD, I. Sack & J. Braun MD

  3. Department of Neurosurgery, University of Leipzig, Liebigstr. 20, 04103, Leipzig, Germany

    F. Arlt MD

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  1. M. Reiss-Zimmermann MD
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Correspondence to M. Reiss-Zimmermann MD.

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M. Reiss-Zimmermann and K.-J. Streitberger contributed equally.

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Reiss-Zimmermann, M., Streitberger, KJ., Sack, I. et al. High Resolution Imaging of Viscoelastic Properties of Intracranial Tumours by Multi-Frequency Magnetic Resonance Elastography. Clin Neuroradiol 25, 371–378 (2015). https://doi.org/10.1007/s00062-014-0311-9

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