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Predictive value of fibrinogen-to-albumin ratio in acute coronary syndrome

Prädiktiver Wert des Fibrinogen-Albumin-Quotienten beim akuten Koronarsyndrom

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Abstract

Background

We aimed to investigate the predictive value of the fibrinogen-to-albumin ratio (FAR) regarding the development of major cardiovascular events (MACE) in patients treated with percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS).

Methods

This was a prospective, observational cohort study that included 261 consecutive patients who were treated with PCI. The patients were grouped according to the occurrence of MACE during the follow-up period.

Results

During follow-up, MACE occurred in 68 (26%) patients. The FAR was independently predictive of MACE (HR: 1.017, 95% CI: 1.010–1.024, p < 0.001). In addition, left ventricular ejection fraction (LVEF) and a diagnosis of ST-segment elevation myocardial infarction (STEMI) were independent predictors of MACE. The area under the curve (AUC) of the multivariable model, including LVEF and diagnosis of STEMI, was 0.707 (95% CI: 0.631–0.782, p < 0.001). When the FAR was added to the multivariable model, the AUC was 0.770 (95% CI: 0.702–0.838, z = 2.820, difference p = 0.0048).

Conclusion

The FAR could be used for the prediction of MACE in patients with ACS who have undergone PCI.

Zusammenfassung

Hintergrund

Ziel der vorliegenden Studie war es, den prädiktiven Wert des Fibrinogen-Albumin-Quotienten (FAR) hinsichtlich der Entstehung schwergradiger kardiovaskulärer Ereignisse (MACE) bei Patienten zu untersuchen, die wegen eines akuten Koronarsyndroms (ACS) mit einer perkutanen Koronarintervention (PCI) behandelt worden waren.

Methoden

Es handelt sich dabei um eine prospektive Beobachtungs-Kohortenstudie mit 261 konsekutiven Patienten, bei denen die Therapie mit einer PCI erfolgte. Die Patienten wurden je nach Auftreten von MACE während des Nachbeobachtungszeitraums eingruppiert.

Ergebnisse

So traten MACE während des Nachbeobachtungszeitraums bei 68 (26 %) Patienten auf. Der FAR war in unabhängiger Weise für MACE prädiktiv (Hazard Ratio, HR: 1,017; 95 %-Konfidenzintervall, 95 %-KI: 1,010–1,024; p < 0,001). Außerdem waren die linksventrikuläre Ejektionsfraktion (LVEF) und die Diagnose eines ST-Strecken-Hebungs-Infarkts (STEMI) unabhängige Prädiktoren für MACE. Im multivariablen Modell einschließlich LVEF und STEMI-Diagnose betrug die Fläche unter der Kurve (AUC) 0,707 (95 %-KI: 0,631–0,782; p < 0,001). Unter Berücksichtigung des FAR beim multivariablen Modell lag die AUC bei 0,770 (95 %-KI: 0,702–0,838; z = 2,820; Differenz bei p = 0,0048).

Schlussfolgerung

Der FAR könnte zur Prädiktion von MACE bei Patienten mit ACS eingesetzt werden, bei denen eine PCI durchgeführt wurde.

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Authors and Affiliations

  1. Faculty of Medicine, Department of Cardiology, Recep Tayyip Erdogan University, Rize, Turkey

    M. Çetin MD, T. Erdoğan MD, S. Özer MD, A. S. Yılmaz MD, H. Durak MD & Ö. Şatıroğlu MD

  2. Ataturk Training and Research Hospital, Department of Cardiology, Izmir Katip Celebi University, Izmir, Turkey

    T. Kırış MD

  3. Department of Cardiology, University of Sutcu Imam, Kahramanmaras, Turkey

    A. Ç. Aykan MD

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  1. M. Çetin MD
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All authors contributed to: (1) substantial contributions to conception and design, or acquisition of data, or analysis and interpretation of data, (2) drafting the article or revising it critically for important intellectual content, and (3) final approval of the version to be published.

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Correspondence to T. Kırış MD.

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Conflict of interest

M. Çetin, T. Erdoğan, T. Kırış, S. Özer, A.S. Yılmaz, H. Durak, A.Ç. Aykan and Ö. Şatıroğlu declare, that they have no competing interests.

All procedures performed in studies involving human participants or on human tissue were in accordance with the ethical standards of the institutional and/or national research committee and with the 1975 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.

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Çetin, M., Erdoğan, T., Kırış, T. et al. Predictive value of fibrinogen-to-albumin ratio in acute coronary syndrome. Herz 45 (Suppl 1), 145–151 (2020). https://doi.org/10.1007/s00059-019-4840-5

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  • DOI: https://doi.org/10.1007/s00059-019-4840-5

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