Skip to main content
Log in

Aktuelles Management der Therapie ventrikulärer Tachykardien durch Katheterablation

Eine Übersicht

Current strategies in the treatment of ventricular tachycardia by catheter ablation

A review

  • Übersichten
  • Published:
Herz Aims and scope Submit manuscript

Zusammenfassung

Die Therapie ventrikulärer Tachykardien unterlag innerhalb der letzten Jahre einem relevanten Wandel. Interventionelle Strategien mittels Katheterablation gewinnen zunehmend an Bedeutung. Verschiedene aktuelle Studien demonstrierten einen Vorteil der Ablationsbehandlung gegenüber der konventionellen medikamentösen Behandlung. Die Identifizierung der effektivsten Techniken sowie der Patientenkollektive, welche am meisten von einem derartigen Eingriff profitieren, ist jedoch weiter Gegenstand aktueller Forschung. Die Vielzahl möglicher Formen und zugrunde liegender Entitäten von ventrikulären Tachykardien und die damit verbundene Notwendigkeit der Kenntnis aktueller Daten zur korrekten Indikationsstellung der Katheterablation stellen entsprechende Herausforderungen an den behandelnden Kardiologen dar. Die vorliegende Übersichtsarbeit fasst die aktuelle Studienlage in prägnanter Form zusammen.

Abstract

The treatment of ventricular tachycardia has recently undergone relevant changes as certain interventional treatment options, such as radiofrequency catheter ablation, have gained in importance. Numerous current publications have demonstrated the advantages of catheter ablation compared to conventional therapy with antiarrhythmic drugs in terms of effectiveness and morbidity. Improving the ablation technique and identifying those patient collectives who are most likely to benefit from ablation are still the objectives of current research. The treatment of ventricular tachycardia in the setting of different cardiac and non-cardiac conditions can be challenging and requires understanding of the current procedures and the recommendations for catheter ablation of ventricular tachycardia. This review succinctly summarizes the current research in this evolving field of interventional cardiology.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1

Literatur

  1. Connolly SJ et al (2000) Canadian implantable defibrillator study (CIDS) : a randomized trial of the implantable cardioverter defibrillator against amiodarone. Circulation 101(11):1297–1302

    Article  CAS  Google Scholar 

  2. Epstein AE et al (2008) ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices): developed in collaboration with the American Association for Thoracic Surgery and Society of Thoracic Surgeons. Circulation 117(21):e350–408

    PubMed  Google Scholar 

  3. Kuck KH et al (2000) Randomized comparison of antiarrhythmic drug therapy with implantable defibrillators in patients resuscitated from cardiac arrest : the Cardiac Arrest Study Hamburg (CASH). Circulation 102(7):748–754

    Article  CAS  Google Scholar 

  4. Aliot EM et al (2009) EHRA/HRS Expert Consensus on Catheter Ablation of Ventricular Arrhythmias: developed in a partnership with the European Heart Rhythm Association (EHRA), a Registered Branch of the European Society of Cardiology (ESC), and the Heart Rhythm Society (HRS); in collaboration with the American College of Cardiology (ACC) and the American Heart Association (AHA). Heart Rhythm 6(6):886–933

    Article  Google Scholar 

  5. Priori SG et al (2015) 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC)Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC). Europace 17(11):1601–1687

    PubMed  Google Scholar 

  6. Aldhoon B et al (2017) Outcomes of ventricular tachycardia ablation in patients with structural heart disease: The impact of electrical storm. PLOS ONE 12(2):e171830

    Article  Google Scholar 

  7. Prystowsky EN et al (2012) Ventricular arrhythmias in the absence of structural heart disease. J Am Coll Cardiol 59(20):1733–1744

    Article  Google Scholar 

  8. Vereckei A et al (2007) Application of a new algorithm in the differential diagnosis of wide QRS complex tachycardia. Eur Heart J 28(5):589–600

    Article  Google Scholar 

  9. Marine JE (2016) Nonsustained ventricular tachycardia in the normal heart: risk stratification and management. Card Electrophysiol Clin 8(3):525–543

    Article  Google Scholar 

  10. Nogami A (2002) Idiopathic left ventricular tachycardia: assessment and treatment. Card Electrophysiol Rev 6(4):448–457

    Article  Google Scholar 

  11. Tada H et al (2005) Idiopathic ventricular arrhythmia arising from the mitral annulus: a distinct subgroup of idiopathic ventricular arrhythmias. J Am Coll Cardiol 45(6):877–886

    Article  Google Scholar 

  12. Tada H et al (2005) Idiopathic premature ventricular contractions arising from the pulmonary artery: importance of mapping in the pulmonary artery in left bundle branch block-shaped ventricular arrhythmias. Circ J 69(7):865–869

    Article  Google Scholar 

  13. Tada H et al (2007) Idiopathic ventricular arrhythmias originating from the tricuspid annulus: Prevalence, electrocardiographic characteristics, and results of radiofrequency catheter ablation. Heart Rhythm 4(1):7–16

    Article  Google Scholar 

  14. Yamada T et al (2009) Idiopathic focal ventricular arrhythmias originating from the anterior papillary muscle in the left ventricle. J Cardiovasc Electrophysiol 20(8):866–872

    Article  Google Scholar 

  15. Hingorani P et al (2016) Arrhythmias seen in baseline 24-hour Holter ECG recordings in healthy normal volunteers during phase 1 clinical trials. J Clin Pharmacol 56(7):885–893

    Article  CAS  Google Scholar 

  16. Kim RJ et al (2007) Clinical and electrophysiological spectrum of idiopathic ventricular outflow tract arrhythmias. J Am Coll Cardiol 49(20):2035–2043

    Article  Google Scholar 

  17. Krittayaphong R et al (2002) Effect of atenolol on symptomatic ventricular arrhythmia without structural heart disease: a randomized placebo-controlled study. Am Heart J 144(6):e10

    Article  Google Scholar 

  18. Aquaro GD et al (2010) Cardiac magnetic resonance predicts outcome in patients with premature ventricular complexes of left bundle branch block morphology. J Am Coll Cardiol 56(15):1235–1243

    Article  Google Scholar 

  19. Hoffmayer KS et al (2013) An electrocardiographic scoring system for distinguishing right ventricular outflow tract arrhythmias in patients with arrhythmogenic right ventricular cardiomyopathy from idiopathic ventricular tachycardia. Heart Rhythm 10(4):477–482

    Article  Google Scholar 

  20. Novak J et al (2016) Electrocardiographic differentiation of idiopathic right ventricular outflow tract ectopy from early arrhythmogenic right ventricular cardiomyopathy. Europace. https://doi.org/10.1093/europace/euw018

    Article  PubMed  PubMed Central  Google Scholar 

  21. Marine JE et al (2013) Prevalence and prognostic significance of exercise-induced nonsustained ventricular tachycardia in asymptomatic volunteers: BLSA (Baltimore Longitudinal Study of Aging). J Am Coll Cardiol 62(7):595–600

    Article  Google Scholar 

  22. Seth N et al (2015) Clinical significance of nonsustained ventricular tachycardia on routine monitoring of pacemaker patients. Pacing Clin Electrophysiol 38(8):980–988

    Article  Google Scholar 

  23. Noda T et al (2005) Malignant entity of idiopathic ventricular fibrillation and polymorphic ventricular tachycardia initiated by premature extrasystoles originating from the right ventricular outflow tract. J Am Coll Cardiol 46(7):1288–1294

    Article  Google Scholar 

  24. Viskin S et al (2005) The „short-coupled“ variant of right ventricular outflow ventricular tachycardia: a not-so-benign form of benign ventricular tachycardia? J Cardiovasc Electrophysiol 16(8):912–916

    Article  Google Scholar 

  25. Ichikawa T et al (2016) Beat-to-beat T‑wave amplitude variability in the risk stratification of right ventricular outflow tract-premature ventricular complex patients. Europace 18(1):138–145

    Article  Google Scholar 

  26. Moss JD, Tung R (2016) Sustained ventricular tachycardia in apparently normal hearts: ablation should be the first step in management. Card Electrophysiol Clin 8(3):623–630

    Article  Google Scholar 

  27. Baman TS et al (2010) Relationship between burden of premature ventricular complexes and left ventricular function. Heart Rhythm 7(7):865–869

    Article  Google Scholar 

  28. Hasdemir C et al (2011) Tachycardia-induced cardiomyopathy in patients with idiopathic ventricular arrhythmias: the incidence, clinical and electrophysiologic characteristics, and the predictors. J Cardiovasc Electrophysiol 22(6):663–668

    Article  Google Scholar 

  29. Takemoto M et al (2005) Radiofrequency catheter ablation of premature ventricular complexes from right ventricular outflow tract improves left ventricular dilation and clinical status in patients without structural heart disease. J Am Coll Cardiol 45(8):1259–1265

    Article  Google Scholar 

  30. Bogun F et al (2007) Radiofrequency ablation of frequent, idiopathic premature ventricular complexes: comparison with a control group without intervention. Heart Rhythm 4(7):863–867

    Article  Google Scholar 

  31. Marchlinski FE et al (2016) Long-term success of irrigated radiofrequency catheter ablation of sustained ventricular tachycardia: post-approval THERMOCOOL VT trial. J Am Coll Cardiol 67(6):674–683

    Article  Google Scholar 

  32. Tanner H et al (2010) Catheter ablation of recurrent scar-related ventricular tachycardia using electroanatomical mapping and irrigated ablation technology: results of the prospective multicenter Euro-VT-study. J Cardiovasc Electrophysiol 21(1):47–53

    Article  Google Scholar 

  33. Poole JE et al (2008) Prognostic importance of defibrillator shocks in patients with heart failure. N Engl J Med 359(10):1009–1017

    Article  CAS  Google Scholar 

  34. Frontera A et al (2016) Safety and mid-term outcome of catheter ablation of ventricular tachycardia in octogenarians. Europace. https://doi.org/10.1093/europace/euw236

    Article  PubMed  Google Scholar 

  35. Halbfass P et al (2017) Catheter ablation of ventricular extrasystoles and ventricular tachycardia in the elderly. Herzschrittmacherther Elektrophysiol. https://doi.org/10.1007/s00399-017-0483-5

    Article  Google Scholar 

  36. Tzou WS et al (2017) Ventricular tachycardia ablation in severe heart failure: an international ventricular tachycardia ablation center collaboration analysis. Circ Arrhythm Electrophysiol. https://doi.org/10.1161/CIRCEP.116.004494

  37. Kumar S et al (2017) Beyond the storm: comparison of clinical factors, arrhythmogenic substrate, and catheter ablation outcomes in structural heart disease patients with versus those without a history of ventricular tachycardia storm. J Cardiovasc Electrophysiol 28(1):56–67

    Article  Google Scholar 

  38. Raymond JM et al (2009) Catheter ablation for scar-related ventricular tachycardias. Curr Probl Cardiol 34(5):225–270

    Article  Google Scholar 

  39. Acosta J et al (2016) Elucidation of hidden slow conduction by double ventricular extrastimuli: a method for further arrhythmic substrate identification in ventricular tachycardia ablation procedures. Europace. https://doi.org/10.1093/europace/euw325

    Article  Google Scholar 

  40. Acosta J et al (2017) Multielectrode vs. point-by-point mapping for ventricular tachycardia substrate ablation: a randomized study. Europace. https://doi.org/10.1093/europace/euw406

    Article  PubMed  Google Scholar 

  41. Kumar S et al (2016) Substrate-based ablation versus ablation guided by activation and entrainment mapping for ventricular tachycardia: a systematic review and meta-analysis. J Cardiovasc Electrophysiol 27(12):1437–1447

    Article  Google Scholar 

  42. Gokoglan Y et al (2016) Scar homogenization versus limited-substrate ablation in patients with nonischemic cardiomyopathy and ventricular tachycardia. J Am Coll Cardiol 68(18):1990–1998

    Article  Google Scholar 

  43. Pascale P et al (2009) Ventricular arrhythmia in coronary artery disease: limits of a risk stratification strategy based on the ejection fraction alone and impact of infarct localization. Europace 11(12):1639–1646

    Article  Google Scholar 

  44. Harkness JR et al (2011) Myocardial ischemia and ventricular tachycardia on continuous electrocardiographic monitoring and risk of cardiovascular outcomes after non-ST-segment elevation acute coronary syndrome (from the MERLIN-TIMI 36 Trial). Am J Cardiol 108(10):1373–1381

    Article  Google Scholar 

  45. Orvin K et al (2016) Outcome of contemporary acute coronary syndrome complicated by ventricular tachyarrhythmias. Europace 18(2):219–226

    Article  Google Scholar 

  46. Di Marco A et al (2016) Chronic total occlusion of an infarct-related artery: a new predictor of ventricular arrhythmias in primary prevention implantable cardioverter defibrillator patients. Europace. https://doi.org/10.1093/europace/euw009

    Article  PubMed  Google Scholar 

  47. Patel D et al (2016) Catheter ablation for ventricular tachycardia (VT) in patients with ischemic heart disease: a systematic review and a meta-analysis of randomized controlled trials. J Interv Card Electrophysiol 45(2):111–117

    Article  Google Scholar 

  48. Santangeli P et al (2016) Comparative effectiveness of antiarrhythmic drugs and catheter ablation for the prevention of recurrent ventricular tachycardia in patients with implantable cardioverter-defibrillators: A systematic review and meta-analysis of randomized controlled trials. Heart Rhythm 13(7):1552–1559

    Article  Google Scholar 

  49. Sapp JL et al (2016) Ventricular tachycardia ablation versus escalation of antiarrhythmic drugs. N Engl J Med 375(2):111–121

    Article  CAS  Google Scholar 

  50. Tanner H et al (2010) Catheter ablation of recurrent scar-related ventricular tachycardia using electroanatomical mapping and irrigated ablation technology: results of the prospective multicenter Euro-VT-study. J Cardiovasc Electrophysiol 21(1):47–53

    Article  Google Scholar 

  51. Della Bella P et al (2004) Incidence and significance of pleomorphism in patients with postmyocardial infarction ventricular tachycardia. Acute and long-term outcome of radiofrequency catheter ablation. Eur Heart J 25(13):1127–1138

    Article  Google Scholar 

  52. Hadid C et al (2011) Incidence, determinants, and prognostic implications of true pleomorphism of ventricular tachycardia in patients with implantable cardioverter-defribillators: a substudy of the DATAS Trial. Circ Arrhythm Electrophysiol 4(1):33–42

    Article  Google Scholar 

  53. Liu E, Josephson ME (2011) Pleomorphic ventricular tachycardia and risk for sudden cardiac death. Circ Arrhythm Electrophysiol 4(1):2–4

    Article  Google Scholar 

  54. Skoda J et al (2016) Catheter ablation of Ischemic ventricular tachycardia with remote magnetic navigation: STOP-VT Multicenter trial. J Cardiovasc Electrophysiol 27(Suppl 1):S29–37

    Article  Google Scholar 

  55. Kuck KH et al (2010) Catheter ablation of stable ventricular tachycardia before defibrillator implantation in patients with coronary heart disease (VTACH): a multicentre randomised controlled trial. Lancet 375(9708):31–40

    Article  Google Scholar 

  56. Dinov B et al (2014) Outcomes in catheter ablation of ventricular tachycardia in dilated nonischemic cardiomyopathy compared with ischemic cardiomyopathy: results from the Prospective Heart Centre of Leipzig VT (HELP-VT) Study. Circulation 129(7):728–736

    Article  Google Scholar 

  57. Kumar S et al (2016) Long-term outcomes after catheter ablation of ventricular tachycardia in patients with and without structural heart disease. Heart Rhythm 13(10):1957–1963

    Article  Google Scholar 

  58. Muser D et al (2016) Long-term outcome after catheter ablation of ventricular tachycardia in patients with Nonischemic dilated Cardiomyopathy. Circ Arrhythm Electrophysiol 9(10):e4328

    Article  CAS  Google Scholar 

  59. Souissi Z et al (2016) Catheter ablation reduces ventricular tachycardia burden in patients with arrhythmogenic right ventricular cardiomyopathy: insights from a north-western French multicentre registry. Europace. https://doi.org/10.1093/europace/euw332

    Article  Google Scholar 

  60. Berruezo A et al (2016) Safety, long-term outcomes and predictors of recurrence after first-line combined endoepicardial ventricular tachycardia substrate ablation in arrhythmogenic cardiomyopathy. Impact of arrhythmic substrate distribution pattern. A prospective multicentre study. Europace. https://doi.org/10.1093/europace/euw212

    Article  PubMed  Google Scholar 

  61. Berte B et al (2016) A new cryoenergy for ventricular tachycardia ablation: a proof-of-concept study. Europace. https://doi.org/10.1093/europace/euw217

    Article  PubMed  Google Scholar 

  62. Tschabrunn CM et al (2016) A swine model of infarct-related reentrant ventricular tachycardia: Electroanatomic, magnetic resonance, and histopathological characterization. Heart Rhythm 13(1):262–273

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to S. Koenig.

Ethics declarations

Interessenkonflikt

S. Koenig, A. Arya und B. Dinov geben an, dass kein Interessenkonflikt besteht. G. Hindricks hat Forschungsunterstützung von Abbott Vascular und Boston Scientific erhalten.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Koenig, S., Arya, A., Hindricks, G. et al. Aktuelles Management der Therapie ventrikulärer Tachykardien durch Katheterablation. Herz 43, 628–632 (2018). https://doi.org/10.1007/s00059-017-4615-9

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00059-017-4615-9

Schlüsselwörter

Keywords

Navigation