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Targeting the hedgehog signaling pathway for cardiac repair and regeneration

Der Hedgehog-Signalweg als Zielpunkt bei kardialer Wiederherstellung und Regeneration

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Abstract

The hedgehog (Hh) signaling pathway is involved in the angiogenesis and development of the coronary vasculature in the embryonic heart. Recently, the Hh signal pathway has emerged as an important regulator that can increase cardiomyocyte proliferation, inhibit cardiomyocyte death and apoptosis, recruit endothelial progenitor cell (EPCs) into sites of myocardial ischemia, and direct stem cells to differentiate into cardiac muscle lineage. Experimental studies have tried to target the Hh signaling pathway for cardiac repair and regeneration. The purpose of this review is to discuss the role of the Hh signal pathway in cardiac repair and regeneration as well as the current strategies targeting the Hh signaling pathway and its potential in heart diseases.

Zusammenfassung

Der Hedgehog(Hh)-Signalweg ist an der Angiogenese und Entwicklung des koronaren Gefäßsystems im embryonalen Herzen beteiligt. Vor Kurzem hat sich der Hh-Signalweg als ein bedeutender Regulator erweisen, der die Kardiomyozytenproliferation erhöhen, Tod und Apoptose von Kardiomyozyten hemmen, endotheliale Vorläuferzellen („endothelial progenitor cells“, EPC) an Orte myokardialer Ischämie locken und Stammzellen so steuern kann, dass sie zu Zellen der Herzmuskelzellreihe ausdifferenzieren. In experimentellen Studien wurde versucht, auf den Hh-Signalweg bei der kardialen Wiederherstellung und Regeneration abzuzielen. Ziel der vorliegenden Übersichtsarbeit ist es, die Bedeutung des Hh-Signalwegs bei der kardialen Wiederherstellung und Regeneration sowie aktuelle Ansätze, die auf den Hh-Signalweg und sein Potenzial bei Herzerkrankungen abzielen, zu erörtern.

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Funding

This study was supported by the natural science foundation of China (NSFC; Project No. 81300092).

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Authors and Affiliations

  1. Department of Geriatrics, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, No. 639, Zhizaoju Road, 200011, Shanghai, China

    Y. Wang, P. Lu & J. Sheng

  2. Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, No. 639, Zhizaoju Road, 200011, Shanghai, China

    D. Zhao

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  1. Y. Wang
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  2. P. Lu
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  3. D. Zhao
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  4. J. Sheng
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Correspondence to D. Zhao or J. Sheng.

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Y. Wang, P. Lu, D. Zhao, and J. Sheng declare that they have no competing interests.

This article does not contain any studies with human participants or animals performed by any of the authors.

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Wang, Y., Lu, P., Zhao, D. et al. Targeting the hedgehog signaling pathway for cardiac repair and regeneration. Herz 42, 662–668 (2017). https://doi.org/10.1007/s00059-016-4500-y

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