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Triglyceride-to-HDL cholesterol ratio

Predictive value for CHD severity and new-onset heart failure

Triglyzerid-HDL-Cholesterin-Ratio

Prädiktiver Wert für KHK-Schweregrad und neu auftretende Herzinsuffizienz

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Abstract

Objective

This study aimed to explore the association between the triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio and the severity of coronary heart disease (CHD). It also evaluated the clinical role of the TG/HDL-C ratio in predicting in-hospital CHD events and the long-term prognosis of CHD patients.

Methods

According to the results of coronary angiography examinations, 317 patients were enrolled in the study and classified into a CHD group (n=233) and a control group (n=84). The TG/HDL-C ratio was calculated at baseline. The CHD group was then further classified into cases of single-branch stenosis (n=79), double-branch stenosis (n=73), and multi-branch stenosis (n=81). The Gensini score was calculated for each group to analyze the relationship between the TG/HDL-C ratio and the severity of CHD.

Results

The TG/HDL-C ratio in the CHD group was significantly higher than in the normal group (P < 0.001). The TG/HDL-C ratio was positively correlated with the Gensini score. The ratio was significantly higher in patients with new-onset heart failure than in those without heart failure events (P < 0.05). An average 3-year follow-up showed that the serum TG/HDL-C ratios of patients with adverse events were significantly higher than other patients (P <  0.01).

Conclusion

The TG/HDL-C ratio is predictive of the severity of CHD. It could also help predict in-hospital new-onset heart failure incidents of CHD patients.

Zusammenfassung

Ziel

Ziel war es, den Zusammenhang zwischen dem Verhältnis von Triglyzerid zu HDL-Cholesterin (TG-HDL-C-Ratio) und dem Schweregrad der koronaren Herzkrankheit (KHK) zu untersuchen sowie die klinische Bedeutung der TG-HDL-C-Ratio für die Prognose bei KHK während des stationären Aufenthalts und auf lange Sicht zu ermitteln.

Methoden

Entsprechend den Koronarangiographiebefunden wurden die 317 in die Studie aufgenommenen Patienten entweder in die KHK-Gruppe (n=233) oder die Kontrollgruppe (n=84) eingeteilt. Zu Studienbeginn wurde die TG-HDL-C-Ratio berechnet. Die KHK-Gruppe wurde dann unterteilt in Ein-Gefäß-Stenose (n=79), Zwei-Gefäß-Stenose (n=73) und Mehr-Gefäß-Stenose (n=81). Zur Auswertung der Beziehung zwischen der TG-HDL-C-Ratio und dem Schweregrad der KHK wurde der Gensini-Score für jede Gruppe berechnet.

Ergebnisse

Die TG-HDL-C-Ratio war in der KHK-Gruppe signifikant höher als in der Kontrollgruppe (p < 0,001). Dabei war die TG-HDL-C-Ratio positiv mit dem Gensini-Score korreliert. Bei Patienten mit neu aufgetretender Herzinsuffizienz war die TG-HDL-C-Ratio signifikant höher als bei Personen ohne Herzinsuffizienzereignisse (p < 0,05). In der durchschnittlichen Nachbeobachtungsphase von 3 Jahren zeigte sich, dass die Serum-TG-HDL-C-Ratio bei Patienten mit unerwünschten Ereignissen signifikant höher war als bei anderen Patienten (p <  0,01).

Schlussfolgerungen

Die TG-HDL-C-Ratio ist ein Prädiktor für den Schweregrad der KHK. Sie konnte auch zur Vorhersage neu auftretender Herzinsuffizienzereignisse während des stationären Aufenthalts bei KHK-Patienten beitragen.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (30900491) and Young Medical Talents Training Program of Shanghai Municipal Health Bureau (XYQ2011011) to Z.Y. Chen, and Shanghai Technology Innovation Program Basic Research Project (10JC1410502) to G.P. Lu.

Conflict of interest

On behalf of all authors, the corresponding author states that there are no conflicts of interest.

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Correspondence to C. Zhenyue.

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Yunke, Z., Guoping, L. & Zhenyue, C. Triglyceride-to-HDL cholesterol ratio. Herz 39, 105–110 (2014). https://doi.org/10.1007/s00059-013-3788-0

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  • DOI: https://doi.org/10.1007/s00059-013-3788-0

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