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Leitliniengerechte Diagnostik von Dyslipidämien

Guidelines-oriented diagnostics of dyslipidemia

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Zusammenfassung

Kardiovaskuläre Erkrankungen stellen die wichtigste Mortalitätsursache für Patienten im fortgeschrittenen Lebensalter dar. Veränderungen des Lipidstoffwechsels sind hierbei als wesentliche Risikofaktoren beteiligt. Dieser Artikel erläutert ein leitliniengerechtes Vorgehen in der Diagnostik von Dyslipidämien. Zunächst erfolgt die Evaluation des kardiovaskulären Gesamtrisikos unter Anwendung der aktuellen Risiko-Charts. Abhängig von diesem Ergebnis kann ein individueller LDL-C-Zielwert definiert werden. Der Artikel fasst zusätzlich relevante kardiovaskuläre Risikofaktoren zusammen, die in den etablierten Risiko-Charts nicht berücksichtigt werden, aber im Einzelfall von Bedeutung sind. Ferner werden die wichtigsten innovativen Biomarker in ihrem diagnostischen Wert und die Anwendungsmöglichkeiten diskutiert.

Abstract

Cardiovascular diseases are the main cause of mortality for patients with advanced age. Changes in lipid metabolism are common and play an important role as key risk factors. This article explains an approach in the diagnosticis of dyslipidemia according to the current guidelines. First, the overall risk evaluation of cardiovascular mortality based on the current chart has to be evaluated. Depending on these results an individual LDL-C goal should be defined. The article also includes other relevant cardiovascular risk factors which were not included in the established risk charts. Furthermore, the main innovative biomarkers are discussed in their possible applications and diagnostic value.

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  1. Institut für Laboratoriumsmedizin, Klinische Chemie und Molekulare Diagnostik, Universitätsklinikum Leipzig, Liebigstr. 27, 04103, Leipzig, Deutschland

    T. Kaiser & J. Thiery

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  1. T. Kaiser
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  2. J. Thiery
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Correspondence to T. Kaiser.

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Kaiser, T., Thiery, J. Leitliniengerechte Diagnostik von Dyslipidämien. Herz 37, 773–782 (2012). https://doi.org/10.1007/s00059-012-3683-0

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