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Genes Causing Inherited Forms of Cardiomyopathies

A Current Compendium

Genetische Ursachen angeborener Kardiomyopathien. Ein Kompendium

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Abstract

Cardiomyopathies (diseases of the heart muscle) are a relevant but heterogeneous group of cardiac diseases. The underlying structural myocardial alterations, detectable with contemporary cardiac imaging modalities and also on twelve-lead surface ECG, embody both linkage and differentiation of the respective clinical forms. Most of these are defined to the heart, however, cardiac involvement is also known in the presence of specific metabolic or muscular systemic diseases. In many of the known cardiomyopathies, a genetic background has been elucidated thus indicating a potential familial disease. This, in turn, also harbors the risk that more family members may be affected besides the index patient.

Zusammenfassung

Kardiomyopathien („Herzmuskelerkrankungen“) sind eine wichtige und heterogene Gruppe von Herzerkrankungen. Ihnen gemeinsam sind Strukturveränderungen im Myokard, die sich mittels kardialer Bildgebung und im EKG erfassen lassen. Bei familiären Kardiomyopathien findet sich definitionsgemäß eine positive Familienanamnese. Kardiomyopathien kommen meist isoliert vor, können aber auch Ausdruck einer Systembeteiligung im Rahmen einer muskulären, metabolischen oder anderen Erkrankung sein. Viele Kardiomyopathien sind genetisch bedingt und bergen damit das Risiko, dass weitere Familienmitglieder betroffen sein können.

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Authors and Affiliations

  1. Department of Cardiology and Angiology, University Hospital Münster, Münster, Germany

    Matthias Paul, Sven Zumhagen, Matthias Koopmann &  Eric Schulze-Bahr

  2. Department of Genetics of Heart Disease, University Hospital Münster, Münster, Germany

    Birgit Stallmeyer &  Eric Schulze-Bahr

  3. Interdisciplinary Center for Clinical Research (IZKF), Münster, Germany

    Birgit Stallmeyer &  Eric Schulze-Bahr

  4. Institute of Pathology, University Hospital Münster, Münster, Germany

    Tilmann Spieker

  5. Universitätsklinikum Münster, Domagkstraße 3, 48129, Münster, Germany

    Eric Schulze-Bahr

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  1. Matthias Paul
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  2. Sven Zumhagen
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  4. Matthias Koopmann
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Correspondence to Eric Schulze-Bahr.

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Both authors contributed equally to the study.

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Paul, M., Zumhagen, S., Stallmeyer, B. et al. Genes Causing Inherited Forms of Cardiomyopathies. Herz 34, 98–109 (2009). https://doi.org/10.1007/s00059-009-3215-8

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  • DOI: https://doi.org/10.1007/s00059-009-3215-8

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