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Recent advances in triazole-benzenesulfonamide hybrids and their biological activities

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Abstract

Hybridization is the process of fusion of two or more existing moieties to make a single molecule. Triazoles and benzenesulfonamides are the useful pharmacological agents possessing a wide spectrum of biological activities such as anti-malarial, anti-bacterial, anti-tumor, anti-cancer, anti-convulsant, analgesic etc. Hybridization of these two represents an advance approach in the direction of synthesis of more potent therapeutic candidates with higher potency and lesser side effects. In literature, several molecules having such benzenesulfonamide and triazole hybrid units in their structure have been synthesized and evaluated for various biological activities. The present review aims to summarize the pharmacological profile of triazole-benzesulfonamide hybrids as CA inhibitors, anti-cancer, anti-microbial, anti-trypanosomal, anti-malarial, anti-inflammatory agents etc. along with structure activity relationship.

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Acknowledgements

One of the authors, SR, is grateful to the J.C. Bose University of Science and Technology, YMCA for providing Seed Research Grant.

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  1. Department of Chemistry, J.C. Bose University of Science & Technology, YMCA, Faridabad, 121006, India

    Chander,  Monika & Sita Ram

  2. Department of Chemistry, Kurukshetra University, Kurukshetra, 136119, India

    Pawan K. Sharma

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Chander, Monika, Sharma, P.K. et al. Recent advances in triazole-benzenesulfonamide hybrids and their biological activities. Med Chem Res 32, 777–801 (2023). https://doi.org/10.1007/s00044-023-03052-8

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