Abstract
A series of new 3-(5-methyl-1-aryl-1H-1,2,3-triazol-4-yl)-1-phenyl-1H-pyrazole-4-carbaldehydes 4(a–g) and their benzimidazole derivatives 6(a–g) were synthesized under both conventional and microwave irradiation methods. However, we successfully achieved good yields in shorter reaction times under microwave irradiation. All the synthesized scaffolds were characterized by 1H NMR, 13C NMR, IR and mass spectral analyses. The synthesized compounds have been evaluated as potential antiproliferative agents. The antiproliferative activity of the synthesized compounds was studied against two cancer cell lines C6 (nerve cells) and MCF-7 (human breast adenocarcinoma cells) and among them, compounds 4g and 6b exhibited highly potent activity against C6 cell line and 6b–c exhibited highly potent activity against MCF-7 cell line.
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Acknowledgements
We are thankful to the Head, Department of Chemistry, Osmania University, for providing laboratory facilities and CFRD OU, for providing analytical support and University Grants Commission and CSIR for financial support. DA is thankful to UGC for the award of UGC-BSR Fellowship.
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Ashok, D., Ram Reddy, M., Nagaraju, N. et al. Microwave-assisted synthesis and in vitro antiproliferative activity of some novel 1,2,3-triazole-based pyrazole aldehydes and their benzimidazole derivatives. Med Chem Res 29, 699–706 (2020). https://doi.org/10.1007/s00044-020-02515-6
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DOI: https://doi.org/10.1007/s00044-020-02515-6