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2-Aryl hydrazonopropanal pharmacophores as potent cytotoxic agents against human hepatocellular carcinoma cell line

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Abstract

The versatile synthon E-methyl 2-(2-(1,3-dioxo-1-arylpropan-2-ylidene) hydrazinyl) benzoate has a potent cytotoxic activity, which was screened in vitro for anticancer activity against human hepatocellular carcinoma cell (HCC) line. The results show a higher anticancer efficacy and higher selectivity index (SI) on HCC versus doxorubicin that warrants further studies in both animals and humans; this work has been patented.

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Acknowledgements

This project was funded by the Deanship of Scientific Research (DSR), King Abdulaziz University, Jeddah, under grant No. (P-0140-363-0436). The authors, therefore, acknowledged with thanks DSR technical and financial support.

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Authors and Affiliations

  1. Chemistry Department, Faculty of Science, University of Jeddah, P.O. Box 80329, Jeddah, 21589, Saudi Arabia

    Khadijah M. Alzaydi & Tamer S. Saleh

  2. Department of Chemistry, Faculty of Science, Al-Faisaliah Campus, King Abdulaziz University, 50918, Jeddah, 21533, Saudi Arabia

    Khadijah M. Alzaydi

  3. Green Chemistry Department, National Research Centre, El Buhouth St., Dokki, Cairo, 12622, Egypt

    Tamer S. Saleh

Authors
  1. Khadijah M. Alzaydi
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  2. Tamer S. Saleh
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Correspondence to Khadijah M. Alzaydi.

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Alzaydi, K.M., Saleh, T.S. 2-Aryl hydrazonopropanal pharmacophores as potent cytotoxic agents against human hepatocellular carcinoma cell line. Med Chem Res 29, 199–205 (2020). https://doi.org/10.1007/s00044-019-02473-8

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