In vitro and in silico evaluation of 2-(substituted phenyl) oxazolo[4,5-b]pyridine derivatives as potential antibacterial agents
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Increasing resistance to antibiotics is a major problem worldwide and stimulates the development of new bacterial inhibitors. Series of oxazolo[4,5-b]pyridine synthesized in our lab was examined to screen them as potential antimicrobial agents. The antimicrobial analyses of the synthesized compound were based on minimum inhibitory concentration determination, against four strains of bacteria. The results showed that the synthesized compounds have elicited good activity profile against methicillin-resistant Staphylococcus aureus (S. aureus), the bacterium that is largely responsible for hospital-acquired infections. Moreover, synthesized compounds were also docked against enterotoxin protein of S. aureus which belongs to Staphylococcal enterotoxin type A(SEA). In vitro and in silico studies revealed that compounds 3d, 3g, and 3h have demonstrated significant antibacterial activity in comparison to the standard control drug ampicillin and streptomycin.
KeywordsAntibacterial Docking Oxazolo[4,5-b]pyridine Staphylococcus enterotoxin A
This work is supported by the financial assistance received from UGC-SAP-DRS-I [No. F. 540/13/DRS-I/2016(SAP-I)] and G.K.R is thankful to UGC-MANF (F1-17.1/2017-18/MANF-2017-18-MAD-73866 /(SA-III/Website)) for Junior Research Fellowship. The authors are thankful to Sophisticated Analytical Instrumentation Facility Punjab University, Chandigarh, for providing experimental results.
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Conflict of interest
The authors declare that they have no competing interests.
- Bernardino AMR, De Azevedo AR, Pinheiro LCD, Borges JC, Carvalho VL, Miranda MD, De Meneses MDF, Nascimento M, Ferreira D, Rebello MA (2007) Synthesis and antiviral activity of new 4-(phenylamino)/4-[(methylpyridin-2-yl)amino]-1-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid derivatives. Med Chem Res 16:352–369CrossRefGoogle Scholar