Design and synthesis of new coumarin–chalcone/NO hybrids of potential biological activity
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This study aims at investigating a synthesis approach based on molecular hybridization strategy through grafting an nitric oxide-releasing moiety, oxime, to coumarin–chalcone hybrids. In vitro anti-proliferative activity of some of the prepared compounds showed moderate activity (growth inhibition values = 45.85, 40.86, 39.25 for compound 8a against leukemia, Central Nervous system and breast cancer cells, respectively). Also, IC50 = 9.62 and 14.40 for compounds 8h and 8f, respectively against breast Michigan Cancer Foundation-7 cell lines. The antibacterial screening results suggest a possible role for nitric oxide in enhancement of the antibacterial activity where nitric oxide is not the only factor but other factors like physicochemical properties should be investigated for their potential role on the activity.
KeywordsCoumarins Chalcones Anti-proliferative Antibacterial Nitric oxide donors Oximes
Thanks to Faculty of Pharmacy, Minia University, Minia, Egypt, and Faculty of Pharmacy, Nahda University at Beni-Suef for their help in conducting the current research.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no competing interests.
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