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Medicinal Chemistry Research

, Volume 26, Issue 12, pp 3077–3090 | Cite as

Design and synthesis of new coumarin–chalcone/NO hybrids of potential biological activity

  • Hany A. El-Sherief
  • Gamal El-Din A. Abuo-Rahma
  • Mai E. Shoman
  • Eman A. Beshr
  • Rehab M. Abdel-baky
Original Research

Abstract

This study aims at investigating a synthesis approach based on molecular hybridization strategy through grafting an nitric oxide-releasing moiety, oxime, to coumarin–chalcone hybrids. In vitro anti-proliferative activity of some of the prepared compounds showed moderate activity (growth inhibition values = 45.85, 40.86, 39.25 for compound 8a against leukemia, Central Nervous system and breast cancer cells, respectively). Also, IC50 = 9.62 and 14.40 for compounds 8h and 8f, respectively against breast Michigan Cancer Foundation-7 cell lines. The antibacterial screening results suggest a possible role for nitric oxide in enhancement of the antibacterial activity where nitric oxide is not the only factor but other factors like physicochemical properties should be investigated for their potential role on the activity.

Graphical abstract

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Keywords

Coumarins Chalcones Anti-proliferative Antibacterial Nitric oxide donors Oximes 

Notes

Acknowledgements

Thanks to Faculty of Pharmacy, Minia University, Minia, Egypt, and Faculty of Pharmacy, Nahda University at Beni-Suef for their help in conducting the current research.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Supplementary material

44_2017_2004_MOESM1_ESM.docx (713 kb)
Supplementary Information

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  1. 1.Pharmaceutical Chemistry Department, Faculty of PharmacyNahda UniversityBenisuefEgypt
  2. 2.Medicinal Chemistry Department, Faculty of PharmacyAl-Jouf UniversityAl-JoufSaudi Arabia
  3. 3.Medicinal Chemistry Department, Faculty of PharmacyMinia UniversityMiniaEgypt
  4. 4.Pharmaceutical Chemistry Department, College of PharmacyUmm Al-Qura UniversityMekkaSaudi Arabia
  5. 5.Microbiology and Immunology department, Faculty of PharmacyMinia UniversityMiniaEgypt

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