Medicinal Chemistry Research

, Volume 26, Issue 10, pp 2692–2698 | Cite as

Synthesis and antiproliferative properties of novel naringenin derivatives

  • Su-You Liu
  • Jiang Zeng
  • Kun-Jian Peng
  • Li-Chao Zhang
  • Li-Jun Liu
  • Zhi-Yong Luo
  • Da-You Ma
Original Research


In order to improve the antiproliferative activity of naringenin, a naturally occurred flavonoid in citrus fruits, a series of naringenin derivatives with a tertiary amino side chain were prepared. The antiproliferative activities of these naringenin derivatives were evaluated on four human cancer cell lines, namely, MCF-7, HCT116, Hela, and A549. Compounds 4a, 9a, and 10a exhibited remarkably enhanced growth inhibition activity. Based on the observed results, the structure–activity relationship of these derivatives was discussed.


Naringenin Antiproliferative activity Synthesis Derivatives 



This work was partially supported by the grants from the National Natural Science Foundation of China (No. 20672147, No. 21472247).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.


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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  1. 1.School of Pharmaceutical SciencesCentral South UniversityChangshaChina
  2. 2.School of Life SciencesCentral South UniversityChangshaChina

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