Synthesis and antiproliferative properties of novel naringenin derivatives
In order to improve the antiproliferative activity of naringenin, a naturally occurred flavonoid in citrus fruits, a series of naringenin derivatives with a tertiary amino side chain were prepared. The antiproliferative activities of these naringenin derivatives were evaluated on four human cancer cell lines, namely, MCF-7, HCT116, Hela, and A549. Compounds 4a, 9a, and 10a exhibited remarkably enhanced growth inhibition activity. Based on the observed results, the structure–activity relationship of these derivatives was discussed.
KeywordsNaringenin Antiproliferative activity Synthesis Derivatives
This work was partially supported by the grants from the National Natural Science Foundation of China (No. 20672147, No. 21472247).
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Conflict of interest
The authors declare that they have no competing interests.
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