Synthesis, antioxidant, and antiviral properties of pyrimidinylsulfamoyl azolyl acetamides
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A new class of pyrimidinylsulfamoyl azolyl acetamides was prepared from 2-pyrimidinylsulfamoyl acetic acid and 2-aminoazoles. The methoxy substituted pyrimidinylsulfamoyl oxazolyl acetamide (8e) displayed moderate antioxidant activity. The methyl and methoxy substituted pyrimidinylsulfamoyl oxazolyl acetamides (8b, 8e) exhibited antiviral activity on BHK 21 cell lines with IC50 63.5, 44.5 µg/mL, respectively. The compound 8e inhibited cytopathic changes induced by Blue Tongue Virus in cell lines.
KeywordsAzoles Pyrimidines Antioxidant activity Antiviral activity
We are grateful to BRNS (Board of Research in Nuclear Sciences) Trombay, Mumbai-400085 for financial assistance under major research project. One of the authors, K.D. is thankful to University Grants Commission (UGC), New Delhi for the sanction of UGC-BSR fellowship.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no competing interests.
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