Synthesis and bioactivity evaluation of novel azoles containing dithiocarbamate moieties
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A series of novel azoles, N-methyl-N-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)]-propyl-(1-substituted phenyl)-dithiocarbamate has been designed, synthesized, and screened for antifungal activity by minimum inhibitory concentration. Results of preliminary antifungal tests showed that most of the title compounds had good antifungal activities against nearly all the tested fungal pathogens, especially against the Candida species. The most surprising finding of this study is that compound 4a, 4e, and 4k exhibited higher activities than fluconazole against Aspergillus fumigatus.
KeywordsAzole Synthesis Antifungal activity CACYP51
This work was supported by the National Natural Science Foundation of China (Nos. 20972188), a Grant from Science & Technology Commission of Shanghai (Nos. 09dZ1976700), and by Shanghai Leading Academic Discipline Project Number: B906.
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Conflict of interest
The authors declare that they have no competing interests.
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