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Medicinal Chemistry Research

, Volume 26, Issue 10, pp 2432–2442 | Cite as

Synthesis and anticancer activity evaluation of a quinoline-based 1,2,3-triazoles

  • Krzysztof Marciniec
  • Małgorzata Latocha
  • Rafał Kurczab
  • Stanisław Boryczka
Original Research

Abstract

A small library of methylthio- or methylseleno-quinolyl-linked 1,4-disubstituted 1,2,3-triazole conjugates has been synthesized from the halogenopropargylthio- or halogenopropargylseleno-quinolines through one-pot click reaction. The ability of all of the synthesized compounds to inhibit the proliferation of the C-32, T-47D, and SNB-19 cell lines was determined using the WST-1 assay. The cytotoxic properties of these new, modified derivatives of quinolyl-triazoles were comparable to those of cisplatin. Two of them, 1-benzyl-4-[methylseleno-(6-chloro-4-quinolyl)]-1H-1,2,3-triazole (2e) and 1-benzyl-4-[methylseleno-(8-bromo-4-quinolyl)]-1H-1,2,3-triazole (2j) demonstrated significant activity on the C-32 and SNB-19 cell lines.

Keywords

1,2,3-triazole Quinoline Anticancer activity CuAAC 

Notes

Acknowledgements

This research was supported by the Medical University of Silesia, grant No. KNW-1–006/K/6/O.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Krzysztof Marciniec
    • 1
  • Małgorzata Latocha
    • 2
  • Rafał Kurczab
    • 3
  • Stanisław Boryczka
    • 1
  1. 1.Department of Organic ChemistryThe Medical University of SilesiaSosnowiecPoland
  2. 2.Department of Molecular BiologyThe Medical University of SilesiaSosnowiecPoland
  3. 3.Institute of PharmacologyPolish Academy of SciencesKrakówPoland

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