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Regioselective synthesis of some new 1,4-disubstituted sulfonyl-1,2,3-triazoles and their antibacterial activity studies

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Abstract

Some new 1,4-disubstituted-sulfonyl-1,2,3-triazoles (3a–f, 5a–h, 7a–d, and 9a–e) were regioselectively synthesized in high yields by Cu(I) catalyzed 1,3-dipolar cycloaddition (DC) reaction of p-acetamidobenzenesulfonyl azide (p-ABSA) with terminal alkynes. These new triazole compounds were evaluated for in vitro antibacterial activity against a panel of Gram-positive Bacillus sphericus, Staphylococcus epidermidis, and Gram-negative Klebsiella pneumonia, Escherichia coli species. Several of these compounds were found to possess comparable growth inhibition activity with the commercial standards Penicillin-G and Streptomycin.

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Acknowledgements

The authors thank the Department of Science and Technology (DST), New Delhi for support through grants SR/S1/IC-31/2011. NST thanks the University Grants Commission (UGC), New Delhi for a research fellowship.

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Authors and Affiliations

  1. Department of Chemistry, Kakatiya University, Warangal, Telangana State, India

    Narasimha Swamy Thirukovela, Shravankumar Kankala, Suresh Paidakula & Ravinder Vadde

  2. Institute of Biotechnology, National Dong-Hwa University, Shou-Feng, Hualien 974, Taiwan, China

    Ranjith Kumar Kankala

  3. Medicinal Chemistry Laboratory, Research Centre, C.K.M. Art’s & Science College, Kakatiya University, Warangal, Telangana State, India

    Mohan Rao Gangula

  4. Department of Pharmaceutical Chemistry, Telangana University, Nizamabad, Telangana State, India

    Chandra Sekhar Vasam

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  1. Narasimha Swamy Thirukovela
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  2. Shravankumar Kankala
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  3. Ranjith Kumar Kankala
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  4. Suresh Paidakula
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  5. Mohan Rao Gangula
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  6. Chandra Sekhar Vasam
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Correspondence to Shravankumar Kankala, Chandra Sekhar Vasam or Ravinder Vadde.

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Thirukovela, N.S., Kankala, S., Kankala, R.K. et al. Regioselective synthesis of some new 1,4-disubstituted sulfonyl-1,2,3-triazoles and their antibacterial activity studies. Med Chem Res 26, 2190–2195 (2017). https://doi.org/10.1007/s00044-017-1926-6

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  • DOI: https://doi.org/10.1007/s00044-017-1926-6

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