Flavonoid rutinosides from Cinnamomum parthenoxylon leaves and their hepatoprotective and antioxidant activity
- 170 Downloads
Cinnamomum parthenoxylon tree belongs to the Lauraceae family. In this study, flavonoid rutinosides were isolated from C. parthenoxylon leaves and their hepatoprotective and antioxidant activity were evaluated. The EtOAc fraction of C. parthenoxylon leaves showed potent hepatoprotective activity on tert-butyl hydroperoxide-induced cytotoxicity in HepG2 cells and also higher antioxidant activity. Ultra-performance liquid chromatography electrospray ionization mass spectrometry analysis revealed that flavonoid rutinosides; rutin, nicotiflorin, and isorhoifolin are major constituents in the EtOAc fraction. The catechol group on B ring in the structure of rutin holds potential for hepatoprotective and antioxidant activity.
KeywordsCinnamomum parthenoxylon Flavonoid rutinoside Hepatoprotective activity Antioxidant activity.
The authors gratefully thank Prof. Kaori Tanaka for her fruitful support.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no competing interests.
- Ajoku GA, Okwute SK, Okogun JI (2015) Isolation of hexadecanoic acid methyl ester and 1,1,2-ethanetricarboxylic acid-1-hydroxy-1, 1-dimethyl ester from the calyx of green Hibiscus Sabdariffa (Linn). Nat Prod Chem Res 3(2):169–174Google Scholar
- Kinjo J, Hitoshi M, Tsuchihashi R, Korematsu Y, Miyakoshi M, Murakami T, Niiho D, Mizutani K, Tanaka T, Nonaka G, Nohara T, Okawa M, Okabe H (2006) Hepatoprotective constituents in plants 15: protective effects of natural-occuring flavonoids and miscellaneous phenolic compounds as determined in an HepG2 cell cytotoxicity assay. J Nat Med 60:36–41CrossRefGoogle Scholar
- Pardede A, Koketsu M (2017) Antioxidant and antileukemic activity of chemical components from bark of Mangifera casturi. Comp Clin Pathol 26:499–504Google Scholar
- Yoshioka T, Inokuchi T, Fujioka S, Kimura Y (2004) Phenolic compounds and flavonoids as plant growth regulators from fruit and leaf of Vitex rotundifolia. Z Naturforsch 59:509–514Google Scholar