Flavonoid rutinosides from Cinnamomum parthenoxylon leaves and their hepatoprotective and antioxidant activity
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Cinnamomum parthenoxylon tree belongs to the Lauraceae family. In this study, flavonoid rutinosides were isolated from C. parthenoxylon leaves and their hepatoprotective and antioxidant activity were evaluated. The EtOAc fraction of C. parthenoxylon leaves showed potent hepatoprotective activity on tert-butyl hydroperoxide-induced cytotoxicity in HepG2 cells and also higher antioxidant activity. Ultra-performance liquid chromatography electrospray ionization mass spectrometry analysis revealed that flavonoid rutinosides; rutin, nicotiflorin, and isorhoifolin are major constituents in the EtOAc fraction. The catechol group on B ring in the structure of rutin holds potential for hepatoprotective and antioxidant activity.
KeywordsCinnamomum parthenoxylon Flavonoid rutinoside Hepatoprotective activity Antioxidant activity.
The authors gratefully thank Prof. Kaori Tanaka for her fruitful support.
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Conflict of interest
The authors declare that they have no competing interests.
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