Medicinal Chemistry Research

, Volume 26, Issue 9, pp 2074–2079 | Cite as

Flavonoid rutinosides from Cinnamomum parthenoxylon leaves and their hepatoprotective and antioxidant activity

  • Antoni Pardede
  • Morina Adfa
  • Arif Juliari Kusnanda
  • Masayuki Ninomiya
  • Mamoru Koketsu
Original Research
  • 170 Downloads

Abstract

Cinnamomum parthenoxylon tree belongs to the Lauraceae family. In this study, flavonoid rutinosides were isolated from C. parthenoxylon leaves and their hepatoprotective and antioxidant activity were evaluated. The EtOAc fraction of C. parthenoxylon leaves showed potent hepatoprotective activity on tert-butyl hydroperoxide-induced cytotoxicity in HepG2 cells and also higher antioxidant activity. Ultra-performance liquid chromatography electrospray ionization mass spectrometry analysis revealed that flavonoid rutinosides; rutin, nicotiflorin, and isorhoifolin are major constituents in the EtOAc fraction. The catechol group on B ring in the structure of rutin holds potential for hepatoprotective and antioxidant activity.

Keywords

Cinnamomum parthenoxylon Flavonoid rutinoside Hepatoprotective activity Antioxidant activity. 

Notes

Acknowledgements

The authors gratefully thank Prof. Kaori Tanaka for her fruitful support.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Supplementary material

44_2017_1916_MOESM1_ESM.pdf (6.7 mb)
Supplementary Information

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Department of Chemistry and Biomolecular Science, Faculty of EngineeringGifu University, 1-1 YanagidoGifuJapan
  2. 2.Department of Chemistry EducationIslamic University of Kalimantan, Jl. Adhyaksa No. 2 Kayu TangiBanjarmasinIndonesia
  3. 3.Department of Chemistry, Faculty of Mathematics and Natural SciencesBengkulu University, Jalan Raya W.R. Supratman, Kandang LimunBengkuluIndonesia

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