Medicinal Chemistry Research

, Volume 26, Issue 7, pp 1359–1366 | Cite as

Synthesis of N′-arylidene-2-(5-aryl-1H-1, 2, 4-triazol-3-ylthio) acetohydrazides as antidepressants

  • Radhika Chelamalla
  • Venkatesham Akena
  • Sarangapani Manda
Original Research

Abstract

A series of N′-arylidene-2-(5-aryl-1H-1, 2, 4-triazol-3-ylthio) acetohydrazide were synthesized. Condensation of aromatic aldehydes with 2-(5-aryl-1H-1, 2, 4-triazol-3-ylthio) acetohydrazide gave corresponding N′ -arylidene-2-(5-aryl-1H-1, 2, 4-triazol-3-ylthio) acetohydrazide. Spectral and elemental analysis was used for structural elucidation of novel 1, 2, 4-triazole schiff bases. The newly synthesized compounds were screened for their antidepressant activity by using tail suspension test in mice. Compound 4l showed significant activity among the series.

Graphical Abstract

A series of new N′-arylidene-2-(5-aryl-1H-1, 2, 4-triazol-3-ylthio)acetohydrazide have been synthesized and characterized. The results revealed that compound 4l with bromo substitution exhibited promising antidepressant activity among the series. Open image in new window

Keywords

Antidepressant activity 1, 2, 4-triazole Acetohydrazide Schiff base Structure-activity relationships 

Notes

Acknowledgements

The authors are thankful to IICT Hyderabad for providing 1H NMR, IR, Mass spectra, and elemental analysis of the compounds. Thanks are also to the management of Malla Reddy group of Institutions for providing research facilities.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Radhika Chelamalla
    • 1
  • Venkatesham Akena
    • 2
  • Sarangapani Manda
    • 2
  1. 1.Center for Pharmaceutical SciencesJawaharlal Nehru Technological University, KukatpallyHyderabadIndia
  2. 2.University College of Pharmaceutical Sciences, Kakatiya UniversityWarangalIndia

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