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Cyclic peroxides as promising anticancer agents: in vitro cytotoxicity study of synthetic ozonides and tetraoxanes on human prostate cancer cell lines

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Abstract

Synthetic ozonides and tetraoxanes were shown to have high cytotoxicity in vitro when tested on androgen-independent prostate cancer cell lines DU145 and PC3, which is in some cases was higher than that of doxorubicin, cisplatin, etoposide, artemisinin, and artesunate. Activity of ozonide stereoisomers differs from each other. This difference in activity and absence of correlation between activity of stereoisomers and their oxidative properties allow us to suggest existence of a quite specific mechanism of cytotoxicity of these endoperoxides different from a traditional mechanism based mainly on oxidative properties of peroxides.

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Acknowledgments

The work on the synthesis and analysis of the organic peroxides was supported by the Russian Science Foundation (Grant № 14-23-00150) and biological experiments were funded by the Ligue Contre le Cancer (Comités 44 and 85).

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Authors and Affiliations

  1. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, Moscow, 119991, Russian Federation

    Ivan A. Yaremenko, Mikhail A. Syroeshkin & Alexander O. Terent’ev

  2. All-Russian Research Institute of Phytopathology, Bol’shie Vyazemy, Moscow region, 143050, Russian Federation

    Ivan A. Yaremenko, Dmitri O. Levitsky & Alexander O. Terent’ev

  3. Mechanism and regulation of DNA repair team Université de Nantes, UFIP CNRS UMR 6286, 2 rue de la Houssinière, Nantes, 44322, France

    Dmitri O. Levitsky & Fabrice Fleury

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  1. Ivan A. Yaremenko
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  2. Mikhail A. Syroeshkin
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  4. Fabrice Fleury
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  5. Alexander O. Terent’ev
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Correspondence to Fabrice Fleury or Alexander O. Terent’ev.

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Yaremenko, I.A., Syroeshkin, M.A., Levitsky, D.O. et al. Cyclic peroxides as promising anticancer agents: in vitro cytotoxicity study of synthetic ozonides and tetraoxanes on human prostate cancer cell lines. Med Chem Res 26, 170–179 (2017). https://doi.org/10.1007/s00044-016-1736-2

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