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Medicinal Chemistry Research

, Volume 26, Issue 1, pp 170–179 | Cite as

Cyclic peroxides as promising anticancer agents: in vitro cytotoxicity study of synthetic ozonides and tetraoxanes on human prostate cancer cell lines

  • Ivan A. Yaremenko
  • Mikhail A. Syroeshkin
  • Dmitri O. Levitsky
  • Fabrice FleuryEmail author
  • Alexander O. Terent’evEmail author
Original Research

Abstract

Synthetic ozonides and tetraoxanes were shown to have high cytotoxicity in vitro when tested on androgen-independent prostate cancer cell lines DU145 and PC3, which is in some cases was higher than that of doxorubicin, cisplatin, etoposide, artemisinin, and artesunate. Activity of ozonide stereoisomers differs from each other. This difference in activity and absence of correlation between activity of stereoisomers and their oxidative properties allow us to suggest existence of a quite specific mechanism of cytotoxicity of these endoperoxides different from a traditional mechanism based mainly on oxidative properties of peroxides.

Graphical Abstract

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Keywords

Ozonide Tetraoxane Peroxide Cytotoxicity Prostate Cancer 

Notes

Acknowledgments

The work on the synthesis and analysis of the organic peroxides was supported by the Russian Science Foundation (Grant № 14-23-00150) and biological experiments were funded by the Ligue Contre le Cancer (Comités 44 and 85).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Supplementary material

44_2016_1736_MOESM1_ESM.doc (2.5 mb)
Supplementary Information

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Ivan A. Yaremenko
    • 1
    • 2
  • Mikhail A. Syroeshkin
    • 1
  • Dmitri O. Levitsky
    • 2
    • 3
  • Fabrice Fleury
    • 3
    Email author
  • Alexander O. Terent’ev
    • 1
    • 2
    Email author
  1. 1.Zelinsky Institute of Organic Chemistry, Russian Academy of SciencesMoscowRussian Federation
  2. 2.All-Russian Research Institute of Phytopathology, Bol’shie VyazemyMoscow regionRussian Federation
  3. 3.Mechanism and regulation of DNA repair team Université de Nantes, UFIP CNRS UMR 6286NantesFrance

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